vitamin-b-12 and Fever

Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000 births, yet the mechanisms by which they arise are unknown. There have been consistent efforts in many fields of research to elucidate the etiology of this multifactorial condition. While no single gene has been identified as a major independent risk factor for NTDs, candidate genes have been proposed that may modify the effects of maternal and/or embryonic exposures. Folate supplementation effectively reduces the occurrence of NTDs and, consequently, has focused much research on metabolism of folate-related pathways during pregnancy and development. Further understanding of normal development and how teratogens can perturb these orchestrated processes also remains at the fore of modern scientific endeavors. The composite of these factors remains fragmented; the aim of this review is to provide the reader with a summary of sentinel and current works in the body of literature addressing NTD disease etiology.

Topics: Central Nervous System; Diabetes Complications; Drug-Related Side Effects and Adverse Reactions; Female; Fever; Folic Acid; Fumonisins; Humans; Neural Tube Defects; Obesity; Pregnancy; Risk Factors; Teratogens; Vitamin B 12

Topics: Aneuploidy; Basophils; Blood Platelets; Cell Transformation, Neoplastic; Child; Clinical Enzyme Tests; Cytogenetics; Eosinophilia; Fetal Hemoglobin; Fever; Hematologic Diseases; Humans; Leukemia, Myeloid; Leukocyte Count; Lymphatic Diseases; Muramidase; Primary Myelofibrosis; Prognosis; Skin Manifestations; Thrombocytosis; Vitamin B 12

Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sickle Cell; Child; Child, Preschool; Feces; Female; Fever; Folic Acid; Hemoglobinopathies; Hookworm Infections; Humans; Infant; Leishmaniasis, Visceral; Malaria; Male; Pregnancy; Protozoan Infections; Schistosomiasis; Vitamin B 12

Topics: Age Factors; Anemia, Pernicious; Animals; Chemical Phenomena; Chemistry; Chickens; Child; Female; Fever; Folic Acid; Haplorhini; Humans; Infant, Newborn; Infant, Premature; Liver; Male; Pregnancy; Rats; Temperature; Vitamin B 12

Vitamin B

Topics: Adult; Diagnosis, Differential; Diet, Vegetarian; Fever; Humans; Hypotension; Male; Pancytopenia; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

Dengue encephalitis and dengue encephalopathy are frequent neurological complications of systemic dengue virus infection. Neuroimaging is normal in approximately 50% of patients. Common imaging abnormalities involve periventricular structures, including the basal ganglion, thalamus, and periventricular white matter. We describe an unusual case of dengue encephalopathy with unilateral imaging abnormalities involving the right cerebral hemisphere and mimicking the involvement of the right middle cerebral artery.

Topics: Adult; Brain; Brain Diseases; Cerebral Ventricles; Dengue; Fever; Folic Acid; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Tomography, X-Ray Computed; Treatment Outcome; Vitamin B 12

Topics: Atrophy; Developmental Disabilities; Female; Fever; Homocysteine; Humans; Infant; Muscle Hypotonia; Neuroimaging; Seizures; Vitamin B 12; Vitamin B 12 Deficiency

Cobalamin C (cblC) defect, the most common inborn error of cobalamin metabolism, is a multisystem disorder usually presenting with progressive neurological, haematological and ophthalmological signs. We report on a cblC patient diagnosed in the newborn age who developed nearly normal during the first year of life. During an upper respiratory tract infection with severe hyperpyrexia at the age of 14months he developed an acute encephalopathic crisis resulting in severe mental retardation and marked internal and external cerebral atrophy. Hyperacute encephalopathic crises have not been observed so far in patients with cblC defect. It remains unclear, if this association is incidental or if the underlying metabolic defect may have predisposed the brain tissue to hyperpyrexia-induced damage.

Topics: Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Fever; Homocystinuria; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Neurodegenerative Diseases; Oxidoreductases; Vitamin B 12; Vitamin B 12 Deficiency

Vitamin B12 deficiency is an uncommon cause of pyrexia. We report the case of a patient who presented with pyrexia and anaemia, which after exclusion of infective, inflammatory or endocrine causes was attributed to megaloblastic anaemia secondary to vitamin B12 deficiency. The patient's fever responded to treatment of vitamin B12 deficiency.

Topics: Adolescent; Anemia, Megaloblastic; Diagnosis, Differential; Fever; Humans; Male; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency

To investigate the protective effects of vitamin B(12), ginseng saponin, and folic acid on mouse embryos subjected to high heat.. Mice were used for the experiment.. After exposure of pregnant mice to high heat, the rates of teratism, stillbirth, and fetal absorption were markedly lower in mice treated with ginseng saponin and folic acid following heat exposure than in untreated mice. There were no significant differences in these rates when comparing mice treated with vitamin B(12) with the untreated mice.. Ginseng saponin and folic acid can lessen injuries to murine embryos caused by high heat, while vitamin B(12) has little protective effect against high temperature except for promoting overall embryonic growth.

Topics: Animals; Congenital Abnormalities; Fetal Diseases; Fever; Folic Acid; Ginsenosides; Mice; Panax; Saponins; Vitamin B 12

Topics: Adult; Anemia; Fever; Heart Valve Prosthesis; Humans; Male; Splenomegaly; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Bacterial Infections; Creatinine; Equipment and Supplies, Hospital; Fever; Formaldehyde; Humans; Inulin; Isoantibodies; Molecular Weight; Phosphates; Renal Dialysis; Time Factors; Vitamin B 12

The 2 children whose cases are reported here both had recurrent episodes of fever and cervical lymphadenopathy. The conventional approach had been unsuccessful in identifying the cause or therapy. In neither case was there an infectious agent demonstrated, and biopsy of a pathologically enlarged lymph gland revealed only reactive hyperplasia in each case. Abnormal metabolism was revealed in the first patient by detecting a substance in urine which is reported to be diagnostic for a form of subacute necrotizing encephalomyelopathy. In the second case, red cell transketolase indicated thiamine pyrophosphate deficiency. Both children had elevated concentrations of folate and B12 in serum. Neither of the 2 patients had further episodes when given a clinical trial with large doses of thiamine hydrochloride. Recurrent episodes of febrile lymphadenopathy are extemely frequent in children and spontaneous resolution occurs, while in others there is either proven or assumed infection. Although final proof of therapeutic efficacy is lacking, the rapid improvement and maintenance of health in both children was striking after conventional therapy had failed.

Topics: Child, Preschool; Fever; Folic Acid; Humans; Lymphatic Diseases; Male; Recurrence; Thiamine; Thiamine Pyrophosphate; Transketolase; Vitamin B 12

Charts of 122 patients with megaloblastic anemia due to either B12 or folic acid deficiency were reviewed for the presence of fever. Fever, defined as a temperature of 100 F (37.8 C) or more, was present in approximately 40% of the patients with both. The elevation was usually minimal but was sometimes over 104 F (40 C), usually in those with more severe anemia and thrombocytopenia, and greater elevations of SGOT and bilirubin concentration. In uncomplicated cases, the temperature returned rapidly to normal after adequate vitamin therapy. Failure of the fever to disappear rapidly with treatment should suggest the probability of some cause other than megaloblastic anemia.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Fever; Folic Acid; Folic Acid Deficiency; Humans; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Aspirin; Ergoloid Mesylates; Fever; Fructose; Humans; Iodine; Magnesium; Meperidine; Methimazole; Phenobarbital; Pneumonia; Prednisolone; Promethazine; Thyroid Crisis; Vitamin B 12

Topics: Anti-Bacterial Agents; Biological Assay; Drug Combinations; Drug Synergism; Erythrocytes; Evaluation Studies as Topic; Fever; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Methionine; Pyrimidines; Sulfamethoxazole; Time Factors; Trimethoprim; Vitamin B 12

Topics: Adult; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Fever; Humans; Male; Middle Aged; Neuralgia; Pain; Pyridoxine; Quinolines; Rheumatic Fever; Urinary Tract Infections; Vitamin B 12

Topics: Adult; Aged; Aminopyrine; Analgesics; Female; Fever; Humans; Joint Diseases; Male; Middle Aged; Pyridoxine; Quinolines; Respiratory Tract Infections; Rheumatic Diseases; Spinal Diseases; Vitamin B 12