vitamin-b-12 and Eye-Diseases

Topics: Amino Acids, Sulfur; Bone Diseases; Cystathionine beta-Synthase; Eye Diseases; Homocysteine; Homocystine; Homocystinuria; Humans; Intestinal Absorption; Methyltransferases; Nervous System Diseases; Skin Diseases; Tetrahydrofolate Dehydrogenase; Thrombosis; Vitamin B 12

Topics: Ascorbic Acid; Drug Synergism; Eye Diseases; Fatty Acids, Essential; Flavonoids; Humans; Niacinamide; Pantothenic Acid; Pyridoxine; Riboflavin; Thiamine; Thiamine Pyrophosphate; Vitamin A; Vitamin A Deficiency; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamin D; Vitamin E; Vitamin K; Vitamins

Topics: Aged; Choline; Clinical Trials as Topic; Eye Diseases; Female; Humans; Macula Lutea; Male; Vitamin B 12; Vitamin B Complex

Behçet's disease is a chronic, multisystemic disease of unknown etiology in which eye involvement is the most common cause of morbidity. In this study, we investigated the possible relation between serum homocysteine level and ocular involvement in patients with Behçet's disease.. One hundred and fifty patients who fulfilled the criteria of the International Study Group for Behçet's disease (96 females and 54 males) were enrolled. All the patients were evaluated carefully by an experienced ophthalmologist for the diagnosis of ocular involvement. Serum homocysteine, vitamin B12, and folate levels were determined. The patients were categorized according to the presence or absence of uveitis. The data were statistically analyzed by using Student's t-test and P values less than 0.05 were considered statistically significant.. Fifty- nine patients (39.3%) had eye involvement, which included anterior uveitis, vitritis, macular damage, optic atrophy, panuveitis, posterior uveitis, retinal vasculitis, and retinal hemorrhage. Serum levels of folate and vitamin B12 were comparable in patients with Behçet's disease. There was no significant correlation between serum homocysteine level in patients with and without eye involvement.. Our findings suggest that homocysteine level does not have significant effect on eye involvement in patients with Behçet's disease.

Topics: Adolescent; Adult; Behcet Syndrome; Comorbidity; Eye Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Young Adult

Considerable discrepancies exist in the literature with respect to plasma total homocysteine (tHcy) levels in Behçet's disease (BD). The aim of this study was to evaluate tHcy concentrations in these patients. Thirty-two patients with BD and 20 age- and body mass index-matched healthy volunteers were enrolled. Plasma tHcy concentrations were significantly higher, while vitamin B12 and folate levels were significantly lower in patients with thrombosis and eye involvement than those without. C-reactive protein levels also correlated significantly in a negative manner with vitamin B12 and folate but positively with tHcy. In conclusion, increased use or accelerated catabolism of folate and vitamin B12 due to chronic inflammation and moderately increased tHcy concentrations related with deficiency of these cofactors, and immunosuppressive drug administration might be potential threats of vascular disease in BD.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Behcet Syndrome; C-Reactive Protein; Colchicine; Drug Therapy, Combination; Eye Diseases; Female; Folic Acid; Glucocorticoids; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Male; Thrombosis; Vitamin B 12

Topics: Cyanides; Eye Diseases; Glutathione; Humans; Smoking; Sulfur; Vitamin B 12

Topics: Benzimidazoles; Evaluation Studies as Topic; Eye Diseases; Humans; Injections; Vitamin B 12

Topics: Adolescent; Adult; Aged; Animals; Child; Cicatrix; Contact Lenses; Cornea; Corneal Injuries; Corneal Ulcer; Eye Diseases; Female; Humans; Hydroxocobalamin; Male; Middle Aged; Rabbits; Vitamin B 12; Wound Healing

Topics: Adolescent; Adult; Aged; Eye Diseases; Female; Humans; Iodides; Male; Middle Aged; Mouth; Niacinamide; Thiamine; Vitamin B 12

Topics: Adolescent; Arachnoiditis; Cerebral Ventriculography; Craniotomy; Eye Diseases; Facial Paralysis; Female; Humans; Ophthalmoscopy; Optic Chiasm; Optic Neuritis; Prednisone; Tuberculosis, Meningeal; Vision Disorders; Visual Fields; Vitamin B 12

Topics: Anti-Infective Agents; Conjunctiva; Contact Lenses; Cornea; Eye Diseases; Humans; Infection Control; Propionates; Sodium; Vitamin A; Vitamin B 12

Topics: Ammonia; Ascorbic Acid; Eye Diseases; Fundus Oculi; Humans; Riboflavin; Thiamine; Urea; Uric Acid; Vitamin B 12; Vitamins

Topics: Adult; Aged; Coenzymes; Eye Diseases; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Vitamin B 12

Topics: Chlorophyll; Chlorophyllides; Cobalt; Eye Diseases; Hematinics; Humans; Neurology; Vitamin B 12

Topics: Diet; Eye Diseases; Humans; Nutrition Assessment; Nutritional Status; Vitamin B 12; Vitamin B Complex

Topics: Eye Diseases; Herpes Zoster; Herpes Zoster Ophthalmicus; Vitamin B 12

Topics: Corrinoids; Eye Diseases; Hematinics; Humans; Ophthalmology; Reinforcement, Psychology; Vitamin B 12

Topics: Corrinoids; Eye Diseases; Humans; Ophthalmology; Vitamin B 12; Vitamin B Complex