vitamin-b-12 and Esophagitis--Peptic

Topics: Esophagitis, Peptic; Gastrectomy; Humans; Ileum; Methods; Postoperative Complications; Pylorus; Stomach; Stomach Ulcer; Transplantation, Autologous; Vitamin B 12

A comparison was done between the F. Paulino jejunal pouch (FP) and a jejunal pouch (JP) as esophagus-duodenum interpositional graft, for replacing the stomach after total gastrectomy. It was investigated the effect of the two procedures on esophagus histology, nutritional state and serum gastrin in rats.. Male Wistar rats weighing 282 +/- 17g were randomly submitted to sham operation (S), FP and JP after total gastrectomy. After eight weeks the rats were killed with overdose of anesthetic and tissue was taken from the distal esophagus for histology. Serum levels of total proteins, albumin, iron, transferring, folate, cobalamine, calcium, as well as serum gastrin were determined. Survival was considered.. Fourty six rats were operated and thirty survived for eight weeks. Five (33.3%) died after FP and 11 (52.3%) after JP (p < 0.05). Postoperative esophagitis occurred in 6 JP rats. At 8th week, no difference was observed on body weight when compared FP and JP rats (p > 0.05). The JP rats had a significant decrease in serum albumin, glucose, transferrin, iron, folate and calcium, compared to sham (p < 0.05). Serum gastrin, iron and calcium were significantly higher in JP rats than in FP rats (p < 0.05). In FP rats, transferrin and cobalamine showed significant decrease comparing the preoperative with 8th week levels (p < 0.05).. F. Paulino pouch in rats had lower mortality than JP, and esophagitis was not detected in it. JP rats had serum gastrin, iron and calcium unaffected, possibly because of preservation of duodenal passage.

Topics: Analysis of Variance; Anastomosis, Roux-en-Y; Animals; Blood Glucose; Duodenum; Esophagitis, Peptic; Esophagus; Gastrectomy; Gastrins; Jejunum; Male; Nutritional Status; Postgastrectomy Syndromes; Rats; Rats, Wistar; Serum Albumin; Vitamin B 12

Since gastric acid plays an important role in the absorption process of iron and vitamin B12, we determined levels of iron, ferritin, vitamin B12, and folic acid in 75 serum samples obtained during continuous omeprazole therapy (6-48 months after start of therapy) from 34 patients with peptic diseases (primarily reflux esophagitis). Serum iron and ferritin levels were decreased in two and three patients, respectively, but there is little evidence that omeprazole administration was causally related to these findings. Serum vitamin B12 and folic acid levels were normal in all cases. We conclude that iron, vitamin B12, and folic acid malabsorption is unlikely to occur, at least within the initial 3-4 years of continuous omeprazole therapy.

Topics: Esophagitis, Peptic; Female; Ferritins; Folic Acid; Gastric Acid; Humans; Iron; Male; Omeprazole; Time Factors; Vitamin B 12

Topics: Aftercare; Dumping Syndrome; Esophagitis, Peptic; Folic Acid; Gastrectomy; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Iron; Neoplasm Recurrence, Local; Nutritional Requirements; Vitamin B 12