vitamin-b-12 and Eczema

Topical vitamin B(12) is an approach that has been shown to successfully treat atopic dermatitis in adults; however, there have been no studies in children. Topical vitamin B(12) is thought to decrease the symptoms involved in eczema through reducing nitric oxide production. Atopic dermatitis affects 5%-20% of children in the United States. Various treatment options are available to treat atopic dermatitis in children, but there are drawbacks to some of these options. Children tend to need a larger dose of medication for body surface area involved and can be more adversely affected by agents such as topical steroids. This study was developed in order to find an alternative eczema treatment for children.. This double-blinded, randomized, placebo-controlled study with intraindividual left/right comparison was set up to determine whether topical vitamin B(12) would be effective in children with eczema.. Patients from the ages of 6 months to 18 years old were recruited from the Center for Family Medicine and enrolled for 4 weeks.. Skin checks using a standardized scoring system were done at baseline, and 2 and 4 weeks by a single investigator. Twenty-one (21) patients completed the study.. Skin treated with topical vitamin B(12) improved significantly more than placebo treated skin at 2 and 4 weeks (p = 0.02, 0.01 respectively).. Topical vitamin B(12) should be considered as a treatment option in children with eczema.

Topics: Administration, Topical; Adolescent; Child; Child, Preschool; Double-Blind Method; Eczema; Humans; Infant; Vitamin B 12

A case of vitamin B12 allergy is reported. Typical eczematous and exanthematic skin lesions appeared after long-term and high-dosed intake of a vitamin B12 drug (Biovital). Patch tests with vitamin B12 were positive. This observation of vitamin B12 allergy we compared with previous published cases.

Topics: Anaphylaxis; Chemical Phenomena; Chemistry; Drug Eruptions; Drug Hypersensitivity; Eczema; Female; Humans; Long-Term Care; Male; Middle Aged; Nausea; Urticaria; Vitamin B 12

Topics: Calcium; Child, Preschool; DNA; Eczema; Gastric Juice; Gastric Mucosa; Histamine; Humans; Infant; Infant, Newborn; Intestinal Mucosa; Phosphorus; RNA; Vitamin B 12

The excretion in the urine of (58)Co after an oral dose of (58)Co vitamin B(12) given together with intrinsic factor has been found to be reduced in a number of patients with psoriasis, eczema, and other less common dermatoses. There is a correlation between the abnormality and the extent of the rash. A reduced glomerular filtration rate was found in a few of the patients in whom it was measured, and this must have been responsible, at least in part, for the reduced excretion of vitamin B(12) in these patients, but abnormal vitamin B(12) excretion also occurred in the absence of impaired renal function. Our evidence is insufficient to show whether malabsorption or increased tissue utilization of vitamin B(12) was the explanation in other cases. Certainly a number of patients had steatorrhoea, and in these it is most likely that malabsorption was the major factor. In patients without steatorrhoea a lone malabsorption of vitamin B(12) cannot be excluded. A decreased serum concentration of vitamin B(12) was found in only one of the patients.

Topics: Adult; Aged; Celiac Disease; Cobalt Isotopes; Creatinine; Darier Disease; Eczema; Fats; Feces; Female; Glomerular Filtration Rate; Humans; Ichthyosis; Lichen Planus; Malabsorption Syndromes; Male; Metabolic Clearance Rate; Middle Aged; Pityriasis Rubra Pilaris; Psoriasis; Skin Diseases; Vitamin B 12

Topics: Bone Marrow Examination; Dermatitis, Exfoliative; Eczema; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Iron; Psoriasis; Stearic Acids; Vitamin B 12

Topics: Cysts; Dermatitis, Exfoliative; Dermatology; Drug Eruptions; Eczema; Lead Poisoning; Liver Diseases; Psoriasis; Quinolines; Skin Neoplasms; Toxicology; Vitamin B 12