vitamin-b-12 and Dyspepsia

Topics: Adult; Aged; Anemia, Hypochromic; Blood Pressure; Body Weight; Dyspepsia; Female; Gastrectomy; Hemoglobins; Humans; Iron; Male; Middle Aged; Peptic Ulcer; Postoperative Complications; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency

The role that vitamin B12 deficiency plays in upper gastrointestinal motor dysfunction is not clear. The aim of this study was to determine whether B12 replacement therapy improves prolonged gastric emptying time in dyspeptic patients with Helicobacter pylori infection.. The study included 34 H. pylori-positive patients who had low serum levels of B12 but had no other factors associated with altered gastric motility. Each patient underwent a radionuclide gastric emptying study before and after 3 months of B12 replacement therapy. Dyspepsia scores were calculated pretherapy and posttherapy using a semiquantitative scale. A vitamin B12 preparation (1000 microg/d) was given intramuscularly for the first 10 days and then orally for 80 days. H. pylori eradication therapy was delayed for 3 months until the posttreatment radionuclide study was completed.. The mean gastric emptying time before B12 treatment was significantly longer than that after treatment (230 +/- 190 minutes vs. 98 +/- 29 minutes, respectively; P < 0.0001). The mean dyspepsia score was also significantly improved by treatment (5.4 +/- 1.0 vs. 1.2 +/- 1.0, respectively; P < 0.0001).. Vitamin B12 deficiency appears to play an important role in the development of gastric dysmotility and its clinical consequences. Replacement therapy will improve gastric emptying in some patients with dyspepsia.

Topics: Adult; Dyspepsia; Female; Gastric Emptying; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Dyspepsia; Female; Homocysteine; Humans; Liver; Male; Peptide Hydrolases; Phosphorylcholine; Vitamin B 12

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Analysis of Variance; Asthenia; Bilirubin; Blood Pressure; Blood Proteins; Child; Clinical Trials as Topic; Dyspepsia; Feeding and Eating Disorders; Humans; Liver Extracts; Liver Function Tests; Middle Aged; Pyridoxine; Statistics as Topic; Vitamin B 12; Wit and Humor as Topic

H. pylori infection has been associated with many micronutrient deficiencies. There is a dearth of data from communities with nutritional deficiencies and high prevalence of H. pylori infection. The aim of this study was to determine the impact of H. pylori infection on serum levels of vitamin B(12), folate and homocysteine in patients with functional dyspepsia (FD).. One hundred and thirty-two patients with FD undergoing gastroscopy were enrolled. The serum was analyzed for B(12), folate and homocysteine levels before gastroscopy. H. pylori infection was diagnosed by histopathological examination of gastric biopsies and urea breath test. An independent sample t-test and the Mann-Whitney test were used to compare mean serum concentrations of biomarkers between H. pylori-positive and H. pylori-negative groups of patients. A Chi-square test was performed to assess the differences among proportions, while Spearman's rho was used for correlation analysis between levels of B(12) and homocysteine.. The mean age of the group was 40.3 ± 11.5 (19-72) years. Folate deficiency was seen in 43 (34.6%), B(12) deficiency in 30 (23.1%) and hyperhomocysteinemia in 60 (46.2%) patients. H. pylori was present in 80 (61.5%) patients with FD while it was absent in 50 (38.5%). Mean serum levels of B(12), folate and homocysteine in the H. pylori-positive group of patients were not significantly different from the levels in the H. pylori-negative group (357 ± 170 vs. 313 ± 136 pg/mL; p = 0.13), (4.35 ± 1.89 vs. 4.42 ± 1.93 ng/mL; p = 0.84); (15.88 ± 8.97 vs. 16.62 ± 7.82 μmol/L; p = 0.24); respectively.B(12) deficiency (≤200 pg/mL) was 23.8% in the H. pylori-positive patients versus 22.0% in the H. pylori-negative patients. Folate deficiency (≤3.5 ng/mL) was 33.8% in the H. pylori-positive group versus 36% in the H. pylori-negative group. Hyperhomocysteinemia (>15 μmol/L) was present in 46.2% of H. pylori-positive patients compared to 44% in the H. pylori-negative group. Correlation analysis indicated that serum B(12) levels were inversely associated with serum levels of homocysteine in patients with FD (rho = -0.192; p = 0.028).. This study demonstrated an inverse relationship between serum levels of B(12) and homocysteine in patients with FD. Moreover, no impact of the presence of H. pylori was found on B(12), folate and homocysteine levels in such patients.

Topics: Adult; Aged; Cross-Sectional Studies; Dyspepsia; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12

To investigate differences in laboratory markers, nutritional status parameters and eating patterns among newly diagnosed patients with functional dyspepsia.. The investigation was performed on 180 newly diagnosed patients with functional dyspepsia, aged 20-79, which were referred to the gastroenterology unit of the Clinical and Hospital Center "Bezanijska Kosa" from April to October 2009. Rome II criteria were used for further classification.. ANOVA Bonferroni post hoc correction outlined that concentrations of serum magnesium and calcium were significantly lower in subjects with ulcer-like dyspepsia, while vitamin B12, glucose and immunoglobulin G level was significantly higher in group with dismotility-like dyspepsia. Statistical analysis revealed that the numbers of meal taken per day were significantly different. There was a statistical trend to skipping meals and to eat fast in patients with ulcer-like and dismotility-like functional dyspepsia when compared with non-specific dyspeptic subjects.. Patients with ulcer-like functional dyspepsia suffered from epigastric pain and burning and from heartburn, while persons with dismotility-like dyspepsia were complaining about postprandial fullness, bloating and early satiety. They skipped meals more frequently and avoided intake of certain supplies which, together with eating habits, provoked or emphasized the annoying symptoms.

Topics: Adult; Aged; Biomarkers; Blood Glucose; Calcium; Dyspepsia; Feeding Behavior; Female; Food; Humans; Immunoglobulin G; Magnesium; Male; Middle Aged; Nutrition Assessment; Nutritional Status; Vitamin B 12; Young Adult

Cobalamin (vitamin B12) deficiency is associated with Helicobacter pylori infection. This study examined how serum vitamin B12 levels relate to gastric mucosa H. pylori density and histology, and to hematological findings in patients with minimal or no gastric atrophy. A second aim was to confirm that H. pylori eradication therapy increases serum B12.. Biopsies of the gastric mucosa from a population of dyspeptic patients were graded for level of chronic inflammation, neutrophil activity, atrophy, and H. pylori density. A total of 145 H. pylori-infected patients with minimal or no atrophy were included in the study. Serum cobalamin level, hemoglobin level, and mean corpuscular volume were measured in the 145 patients before eradication therapy, and in 65 of the subjects after treatment. The hematologic findings before and after eradication therapy and correlations between serum vitamin B12 level and histologic parameters, hematologic findings, and patient age were statistically analyzed.. There was no significant correlation between serum cobalamin level and patient age. Before treatment all the histopathological scores were inversely correlated with serum vitamin B12 level (p <.01) on univariate analysis. Only H. pylori density was significantly associated with B12 level on multivariate analysis. Serum hemoglobin and cobalamin levels were significantly increased after treatment, regardless of H. pylori eradication status (p <.001).. The findings provide strong evidence that H. pylori infection is associated with cobalamin deficiency, and show that this is true even in patients with non-ulcer dyspepsia and minimal or no gastric atrophy.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dyspepsia; Erythrocyte Indices; Female; Gastric Mucosa; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Hemoglobins; Humans; Male; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Animals; Cattle; Cattle Diseases; Culture Media; Dyspepsia; Lactobacillus acidophilus; Propionibacterium; Russia; Vitamin B 12

Topics: Adult; Aged; Body Weight; Disability Evaluation; Duodenal Ulcer; Dyspepsia; Female; Follow-Up Studies; Humans; Male; Mental Disorders; Middle Aged; Neurologic Examination; Neurologic Manifestations; Pain; Peptic Ulcer; Postgastrectomy Syndromes; Postural Balance; Sensation; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Aged; Body Weight; Dyspepsia; Female; Follow-Up Studies; Humans; Male; Mental Disorders; Middle Aged; Neurologic Examination; Peptic Ulcer; Postgastrectomy Syndromes; Postural Balance; Sensation; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Pernicious; Biopsy; Body Weight; Dumping Syndrome; Duodenal Ulcer; Dyspepsia; Female; Follow-Up Studies; Gastrectomy; Gastric Mucosa; Hemoglobins; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Male; Postgastrectomy Syndromes; Schilling Test; Stomach Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

An investigation of 102 men comprising alcoholics, patients with non-ulcer dyspepsia, and healthy controls is reported. It demonstrates that alcohol is a cause of chronic gastritis and the severity of the mucosal lesion is directly related to the duration of excess drinking. Contrary to popular belief, chronic gastritis does not give rise to symptoms. The effect of alcohol on the gastric mucosa is a direct one and is not mediated by malnutrition, hepatic damage, intestinal malabsorption, anaemia, ascorbic acid deficiency, or any disturbance in immune tolerance. The natural history of chronic gastritis is described, involving an initial hypertrophy and hyperfunction of the gastric mucosa, followed by atrophy and hypofunction. Cigarette smoking is confirmed as another cause of chronic gastritis. The non-ulcer dyspepsia syndrome is unrelated to chronic gastritis.

Topics: Adolescent; Adult; Alcoholism; Atrophy; Chronic Disease; Dyspepsia; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Hypertrophy; Male; Middle Aged; Nutrition Disorders; Radiography; Smoking; Time Factors; Vitamin B 12

Topics: Adolescent; Age Factors; Body Weight; Child; Child, Preschool; Citrates; Copper; Dyspepsia; Feeding and Eating Disorders; Gastroenteritis; Humans; Infant; Infant, Newborn; Iron; Manganese; Nucleotides; Respiratory Tract Infections; Vitamin B 12

Topics: Age Factors; Animals; Bacteria; Bacteriological Techniques; Cattle; Cattle Diseases; Culture Media; Dyspepsia; Milk; Vitamin B 12; Yeasts

Topics: Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Biliary Dyskinesia; Dyspepsia; Female; Folic Acid; Gallbladder Diseases; Gastritis; Humans; Liver Diseases; Male; Middle Aged; Niacinamide; Vitamin B 12

Topics: Animals; Breast Feeding; Dogs; Dyspepsia; Growth; Humans; Infant; Infant Nutrition Disorders; Vitamin B 12

Topics: Breast Feeding; Corrinoids; Dyspepsia; Fats; Humans; Infant; Infant Nutrition Disorders; Vitamin B 12; Vitamin B Complex