vitamin-b-12 and Dengue

Dengue encephalitis and dengue encephalopathy are frequent neurological complications of systemic dengue virus infection. Neuroimaging is normal in approximately 50% of patients. Common imaging abnormalities involve periventricular structures, including the basal ganglion, thalamus, and periventricular white matter. We describe an unusual case of dengue encephalopathy with unilateral imaging abnormalities involving the right cerebral hemisphere and mimicking the involvement of the right middle cerebral artery.

Topics: Adult; Brain; Brain Diseases; Cerebral Ventricles; Dengue; Fever; Folic Acid; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Tomography, X-Ray Computed; Treatment Outcome; Vitamin B 12

To document correlation between vitamin B12 deficiency and severity of thrombocytopenia, platelate recovery and duration of hospital stay in dengue fever patients.. This prospective observationl study was done in dengue fever patient with severe prolonged thrombocytopenia (<20,000 µl and > 2 days duration). Patient with underlying malignancy, hematological disorders, septicemia, or use of any drug which may cause thrombocytopenia, were excluded. Standard statistical methods were used.. Total 40 subjects were included in current study. Twenty one were male and mean age was 25±12 years. Forty percent sujects were having B12 level < 200 pg/L and mean B12 level was 336.9±362.36 pg/L. SDP requirement was highest in B12<100 pg/L group was (3±1.41) as compmared to other groups Time required for recovery of platelates to 20000/µl thresold, was also highest in B12<100 pg/L group (5.75±0.95days) as compmared to other groups. Duration of hospital stay was also highest in B12<100 pg/L group (5.25±1.25days) as compmared to other groups. There was no relation between B12 levels and other complications of dengue like bleeding, serositis, and shock.. Our study suggests that B12 deficiency may responsible for severe thrombocytopenia; slower platelates count recovery and prolonged hospitalisation in dengue fever patients.

Topics: Adolescent; Adult; Dengue; Female; Humans; Leukopenia; Male; Prospective Studies; Thrombocytopenia; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult