vitamin-b-12 and Cheilitis

Skin manifestations, including scalded skin, desquamation, and chronic periorificial dermatitis, are rare clinical signs in patients with methylmalonic acidemia. This condition may be due to enzyme deficiency or multi-nutrient deficiency because of nutritional restriction. Bullous skin lesion is very rare in these patients and consequently, this type of skin lesion can be the presenting sign of methylmalonic acidemia.

Topics: Acid-Base Equilibrium; Amino Acid Metabolism, Inborn Errors; Blister; Cheilitis; Child, Preschool; Consanguinity; Dermatitis, Perioral; Erythema; Female; Humans; Infant; Lethargy; Male; Vitamin B 12

The mucocutaneous changes observed during vitamin B12 deficiency in children have been published only as case studies and small case series. In this study, we aimed to demonstrate the frequency of mucocutaneous changes (particularly hyperpigmentation) seen during vitamin B12 deficiency and resolving time of these symptoms with vitamin B12 treatment.. This prospective study was conducted at the pediatrics outpatient clinic of Harran and Yuzuncu Yil University Faculty of Medicine, among 57 patients, aged between 6 and 24 months, who were diagnosed with vitamin B12 deficiency following various examinations and tests. A detailed examination was performed in respect to skin and mucosal findings. Patients with vitamin B12 deficiency were administered intramuscular cyanocobalamin. Prospective examination was continued, and resolving time of symptoms after treatment was recorded.. The mean age of the patients enrolled in the study was found to be 12.75 ± 4.75. Hyperpigmentation was reported in 49 (85.96%) patients enrolled in the study; atrophic glossitis in 40 (70.17%), brittle and matt hair in 13 (22.80%), skin lesions (particularly diaper dermatitis) in eight (15.78%) and cheilosis in four (7.01%) patients. Three months after the treatment initiation, hyperpigmentation improved in 87.75%, atrophic glossitis in 97.5% and brittle and matt hair in 92.3% of the patients. Five patients (8.77%) with continuing pigmentation by the end of sixth months were considered as nonresponsive to the treatment.. Deficiency of vitamin B12 should be considered in the differential diagnosis of infants who present with skin and mucosal lesions.

Topics: Cheilitis; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Glossitis; Humans; Hyperpigmentation; Infant; Injections, Intramuscular; Prospective Studies; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency

The oral manifestations of glossitis, stomatitis and mucosal ulceration in vitamin B12 deficiency have long been recognised. These oral changes may occur in the absence of symptomatic anaemia or of macrocytosis. The aim of this paper is to describe a retrospective study of the wide range of oral signs and symptoms reported by 14 patients found to have a previously undiagnosed vitamin B12 deficiency. None of the patients described in this study had generalised symptoms sufficiently advanced to arouse suspicions of vitamin B12 deficiency. The essential criteria for the diagnosis of pernicious anaemia are also discussed.

Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Burning Mouth Syndrome; Cheilitis; Female; Glossalgia; Glossitis; Humans; Male; Mouth Diseases; Mouth Mucosa; Retrospective Studies; Stomatitis; Stomatitis, Denture; Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Cheilitis; Cobalt; Dermatitis, Contact; Female; Humans; Middle Aged; Vitamin B 12

Topics: Accidents, Traffic; Adolescent; Adult; Ascorbic Acid Deficiency; Calcium; Cheilitis; Diet; Dietary Fats; Gangrene; Hemoglobins; Humans; Intestinal Absorption; Intestine, Small; Iron; Leukocyte Count; Magnesium; Magnesium Deficiency; Male; Oligosaccharides; Pain; Prothrombin Time; Tetany; Vitamin A Deficiency; Vitamin B 12; Vitamin D