vitamin-b-12 and Cerebral-Palsy

Topics: Cerebral Palsy; Child; Folic Acid; Humans; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cerebral Palsy; Disease Models, Animal; Male; Memory; Mice; MicroRNAs; Motor Activity; Neurons; Neuroprotection; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Thiamine; Vitamin B 12

We observed high incidence of anemia in patients with cerebral palsy sheltered in a specialized institution in Thessaloniki, Greece. Therefore, we decided to investigate its cause. We studied 108 patients, and assessed complete blood cell count, peripheral blood smear, serum iron, ferritin, folate, B12 and the presence of hemoglobin or parasites in the stools. In all cases, anemia was hypochromic and microcytic. Approximately 33% of patients suffered from hypochromic anemia, whereas 38% were iron deficient. There was no statistical difference in the incidence of iron deficiency between different age groups. All tests for fecal occult blood or intestinal parasites were negative. Folic acid and B12 levels were within normal range in all cases. We also found that 87 and 95.6% of patients on liquid diet were anemic and iron deficient, respectively, compared to only 18.8 and 22.3% of patients on normal diet. The high incidence of anemia was attributed to iron deficiency which was secondary to inadequate iron intake and decreased iron absorption. Thus, it would not be irrational to consider iron supplementation as the first measure in such patients and postpone endoscopic procedures for a later stage, unless there are clinical or laboratory findings (such as fecal occult blood) suggestive of gastrointestinal blood loss.

Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Cerebral Palsy; Child; Dietary Supplements; Female; Ferritins; Folic Acid; Greece; Hemoglobins; Humans; Incidence; Institutionalization; Iron; Male; Vitamin B 12

Topics: Cerebral Palsy; Child; Child, Preschool; Humans; Nutritional Status; Vitamin B 12

Topics: Acid-Base Equilibrium; Adrenocorticotropic Hormone; Cerebral Palsy; Dexamethasone; Exercise Therapy; Humans; Hydrocephalus; Infant; Infant, Newborn; Nystagmus, Pathologic; Pyrogens; Vitamin B 12

Topics: Adolescent; Avitaminosis; Cerebral Palsy; Child; Humans; Niacinamide; Pyridoxine; Thiamine; Vitamin B 12

Topics: Cerebral Palsy; Child; Developmental Disabilities; Humans; Infant, Newborn; Infant, Newborn, Diseases; Physical Therapy Modalities; Speech Disorders; Vitamin B 12

Topics: Adolescent; Cerebellar Diseases; Cerebral Palsy; Child; Corrinoids; Drug Therapy; Electric Stimulation Therapy; Galantamine; Humans; Hyperkinesis; Infant; Movement Disorders; Vitamin B 12

Topics: Acetylcholine; Atropine; Cerebral Palsy; Child; Child, Preschool; Chlorpromazine; Hearing Disorders; Humans; Infant; Infant, Newborn; Mephenesin; Muscles; Parasympatholytics; Piperidines; Procaine; Pyridoxine; Speech Disorders; Thiamine; Vision, Ocular; Vitamin B 12

Topics: Cerebral Palsy; Child; Clinical Laboratory Techniques; Down Syndrome; Electrocardiography; Electrophysiology; Humans; Hyperthyroidism; Hypothyroidism; Infant; Infant, Newborn; Meningitis; Physiology; Reflex; Reflex, Abnormal; Triiodothyronine; Vitamin B 12