vitamin-b-12 and Blindness

To report bone marrow derived stem cell application in a patient with bilateral visual loss due to accidental ingestion of methanol.. A 22-year-old male patient with bilateral visual loss at discharge after treatment for methanol ingestion was treated with retrobulbar and intrathecal autologus bone marrow derived stem cells in an outpatient setting. The procedure was followed by Vit B12 Injection 500 mcg alternate days and oral vitamins B1, B2, B6, in therapeutic dose for 3 months.. The patient demonstrated favorable outcome three days after the treatment. Visual acuity improved to 20/20 in both eyes by third week.. Treatment with retrobulbar and intrathecal autologous bone marrow derived stem cell in an adult male patient with bilateral visual loss due to accidental ingestion of methanol was effective. Larger studies are warranted to explore the real impact of this procedure.

Topics: Blindness; Bone Marrow Cells; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Injections, Intraocular; Injections, Spinal; Male; Methanol; Recovery of Function; Riboflavin; Thiamine; Transplantation, Autologous; Treatment Outcome; Vitamin B 12; Vitamin B 6; Young Adult

Topics: Adult; Aged, 80 and over; Blindness; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

Administration of vitamin B12 (VB12) has been reported to normalize human sleep-wake rhythm disorders such as non-24-h sleep-wake syndrome (HNS), delayed sleep phase syndrome (DSPS) or insomnia. However, the mechanisms of the action of VB12 on the rhythm disorders are unknown. In the present study, therefore, effects of VB12 on circadian rhythms of locomotor activity were examined in mice. In the first experiment, CBA/J mice were maintained under continuous light condition (LL) or blinded, and after free-running rhythms became stable, the mice were intraperitoneally injected with either VB12 or saline at a fixed time every day. In all the mice with tau > 24 h, saline injections resulted in entrainment of circadian rhythms, whereas not all the mice with tau < 24 h entrained to the injection. In contrast to saline injections, VB12 injections did not always induce entrainment and about half of the mice with tau > 24 h free-ran during the injection. In the second experiment, the amount of phase advances of circadian rhythms induced by a single injection of saline at circadian time (CT) 11 under LL was compared between the mice with and without VB12 silastic tubes. The results showed that the amplitude of phase advances was smaller in the mice with VB12 than those without VB12. In the third experiment, daily injections of saline were given to the mice with VB12 silastic tubes maintained under LL. In this chronic treatment of VB12 as well, attenuating effects of VB12 on saline-induced entrainment were observed. These results suggest that VB12 affects the mechanisms implicated in non-photic entrainment of circadian rhythms in mice.

Topics: Animals; Blindness; Circadian Rhythm; Darkness; Drug Administration Schedule; Humans; Injections, Intraperitoneal; Light; Male; Mice; Mice, Inbred CBA; Motor Activity; Reference Values; Regression Analysis; Sleep; Vitamin B 12; Wakefulness

Topics: Animals; Behavior, Animal; Blindness; Circadian Rhythm; Drinking; Male; Motor Activity; Rats; Rats, Inbred Strains; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Alcoholism; Amblyopia; Blindness; Cyanides; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Nicotiana; Nicotine; Nutrition Disorders; Plants, Toxic; Smoking; Vitamin B 12

Topics: Blindness; Cerebral Arterial Diseases; Diagnosis, Differential; Drug Therapy; Humans; Niacin; Nicotinic Acids; Spasm; Thiamine; Vision Disorders; Visual Fields; Vitamin B 12; Vitamin B Complex

Topics: Blindness; Child; Dietary Supplements; Growth; Hearing Disorders; Humans; Infant; Nutrition Disorders; Puberty; Sexual Maturation; Vitamin B 12