vitamin-b-12 and Biliary-Tract-Diseases

Topics: Abetalipoproteinemia; Amino Acids; Biliary Tract Diseases; Bone Marrow Diseases; Celiac Disease; Child, Preschool; Cystic Fibrosis; Folic Acid; Humans; Infant; Infant, Newborn; Intestinal Obstruction; Intestine, Large; Intestine, Small; Lipidoses; Magnesium; Malabsorption Syndromes; Pancreatic Diseases; Postoperative Complications; Protein-Losing Enteropathies; Sprue, Tropical; Vitamin B 12; Whipple Disease; Xanthomatosis

Topics: Bile Acids and Salts; Biliary Fistula; Biliary Tract Diseases; Cholestyramine Resin; Chylomicrons; Colloids; Colonic Diseases; Feces; Gallbladder Diseases; Gastrointestinal Diseases; Humans; Intestinal Absorption; Intestinal Fistula; Intestinal Mucosa; Lipid Metabolism; Lipids; Liver Diseases; Macromolecular Substances; Malabsorption Syndromes; Neomycin; Pancreas; Solubility; Vitamin B 12; Xylose; Zollinger-Ellison Syndrome

Topics: Bacteroides; Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Cholestyramine Resin; Diagnosis, Differential; Digestion; Escherichia coli; Fatty Acids; Humans; Ileum; Intestinal Diseases; Intestinal Obstruction; Intrinsic Factor; Lipid Metabolism; Liver Circulation; Malabsorption Syndromes; Metabolic Diseases; Triglycerides; Vitamin B 12

Topics: Adult; Animals; Biliary Tract Diseases; Child; Diabetes Mellitus; Female; Humans; Hyperglycemia; Intracranial Pressure; Liver Diseases; Pregnancy; Prenatal Care; Rats; Sorbitol; Vitamin B 12

Using dialysis, gel filtration, isoelectrofocusing and radioaffinity assay, we studied the unsaturated and saturated binders of bile and the biliary concentration of cobalamin (Cbl) and Cbl analogues compared to the corresponding serum concentrations in 7 choledochodomized patients. Bile contained a single saturated or unsaturated R binder with a molecular mass of about 120,000. Differences in the isoelectrofocusing pattern were observed between unsaturated and saturated R binders and could correspond to two secretion origins, mucosal secretion and hepatocyte clearance, respectively. The concentration of total corrinoids is about 4 times higher in bile than in serum, and this could be explained by a hepatic clearance of serum Cbl analogue-R binder complexes, as previously described in the rabbit. Moreover, the enterohepatic circulation of Cbl seems likely in healthy individuals since the saturated biliary R binder is degraded by pancreatic juice.

Topics: Animals; Bile; Biliary Tract Diseases; Corrinoids; Enterohepatic Circulation; Humans; Swine; Transcobalamins; Vitamin B 12

Abnormalities in some transcobalamin unsaturated binding capacities (TC-UBBC) were found in some patients with treated pernicious anemia who had elevated TC II-UBBC, R-UBBC, and total UBBC, in gastrectomized patients with latent vitamin B12 deficiency who had elevated R-UBBC and UBBC, and in patients with obstructive jaundice who had elevated TC II-UBBC and UBBC. No abnormalities were found in patients who had untreated pernicious anemia, folate deficiency, unclassifiable megaloblastic anemia, tobacco amblyopia, or low serum B12 level but normal capacity to absorb vitamin B12.

Topics: Anemia, Pernicious; Biliary Tract Diseases; Blood Proteins; Female; Humans; Liver Diseases; Male; Sex Factors; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Aged; Arteriosclerosis; Biliary Tract Diseases; Carbohydrate Metabolism; Coronary Disease; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Hypertension; Male; Middle Aged; Nucleotides; Obesity; Pyridoxine; Taurine; Vitamin B 12

Topics: Adolescent; Adult; Aged; Anemia; Anemia, Hypochromic; Biliary Tract Diseases; Biometry; Cardiovascular Diseases; Erythrocyte Count; Erythrocytes; Erythrocytes, Abnormal; Female; Gastrointestinal Diseases; Hematologic Diseases; Hemophilia A; Humans; Leukemia; Liver Diseases; Lung Diseases; Male; Middle Aged; Neoplasms; Pancreatic Diseases; Splenectomy; Thalassemia; Thyroid Diseases; Urologic Diseases; Vitamin B 12

Topics: Adjustment Disorders; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthenia; Biliary Tract Diseases; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Hypotension; Leukemia; Lung Diseases; Male; Middle Aged; Porphyrins; Pyridoxine; Urologic Diseases; Vitamin B 12

Topics: Anemia, Macrocytic; Animals; Bile; Biliary Tract Diseases; Cobalt Isotopes; Dogs; Feces; Intestinal Absorption; Liver; Rats; Vitamin B 12

Topics: Bile; Bile Acids and Salts; Biliary Tract Diseases; Cholangitis; Cholelithiasis; Cholestasis; Chromatography, Thin Layer; Escherichia coli Infections; Gallstones; Humans; Tryptophan; Vitamin B 12

Topics: Adolescent; Adult; Aged; Arginine; Biliary Tract Diseases; Citrulline; Female; Folic Acid; Humans; Liver Diseases; Male; Middle Aged; Niacinamide; Ornithine; Vitamin B 12

Topics: Biliary Tract Diseases; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Liver; Health Resorts; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Vitamin B 12

Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Heart Diseases; Hepatitis A; Humans; Hypersplenism; Liver Cirrhosis; Liver Extracts; Lung Diseases; Middle Aged; Vitamin B 12; Vitamin E; Vitamin K 1