vitamin-b-12 and Anemia--Hemolytic--Autoimmune

Premacular retrohyaloid hemorrhage is a rare complication of acute severe anemia. The authors report two cases of premacular hemorrhage in which no treatment other than clinical and spectral-domain optical coherence tomography observation was performed. The natural history of this condition reveals that complete clinical resolution is not accompanied by full anatomical restoration. [Ophthalmic Surg Lasers Imaging Retina. 2014;45:E5-E7.].

Topics: Acute Disease; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Megaloblastic; Blood Transfusion; Fluorescein Angiography; Folic Acid; Folic Acid Deficiency; Glucocorticoids; Humans; Male; Retinal Hemorrhage; Thrombocytopenia; Tomography, Optical Coherence; Vision Disorders; Visual Acuity; Vitamin B 12; Vitamin B 12 Deficiency

Haematological complications are common in HIV patients and it can be because of infection per se or secondary to opportunistic infections and antiretroviral therapy. Evan's syndrome, i.e., autoimmune haemolytic anaemia with thrombocytopenia is however a very rare occurrence inspite of high direct Coomb's test positivity in HIV patients. We are reporting one such rare case of Evan's syndrome in HIV patient probably first such reported case from India.

Topics: Adult; AIDS-Related Opportunistic Infections; Anemia, Hemolytic, Autoimmune; Antiretroviral Therapy, Highly Active; Erythrocyte Transfusion; Glucocorticoids; HIV Infections; Humans; Male; Prednisolone; Thrombocytopenia; Treatment Outcome; Vitamin B 12; Vitamin B Complex

We report a 16-year-old male with a combination of pernicious anemia, auto-immune hemolytic anemia and alopecia areata. Autoimmune hemolytic anemia coexisted with pernicious anemia but was diagnosed only when the anemia failed to respond to cobalamin therapy. Alopecia areata occurred 9 years later.

Topics: Administration, Oral; Adolescent; Alopecia Areata; Anemia, Hemolytic, Autoimmune; Anemia, Pernicious; Drug Administration Schedule; Erythrocyte Transfusion; Follow-Up Studies; Humans; Injections, Intramuscular; Male; Steroids; Treatment Outcome; Vitamin B 12

In various anaemias the values of 8 acute phase factors were determined simultaneously before and at the end of treatment: seromucoid, sialic acid, acid alpha 1-glycoprotein, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, transferrin and fibrinogen. In iron-deficiency anaemia without coexistent inflammatory changes in organs the levels of 4 proteins--seromucoid, alpha 1-antitrypsin, ceruloplasmin and transferrin, were consistently raised. In iron-deficiency anemia with concomitant infection 4 proteins also were increased, but in place of alpha 1-antitrypsin the haptoglobin level was raised. In megaloblastic anaemia the ceruloplasmin level was increased, and in haemolytic anaemia one factor--sialic acid--was decreased. At the end of treatment the concentrations of certain proteins were changed depending on their specific role in various forms of anaemia and on various additional factors. In iron-deficiency anaemia without coexistent infection the concentration of seromucoid was decreased, and in this anaemia with coexistent infection alpha 1-antitrypsin, haptoglobin, and fibrinogen levels were raised, in haemolytic anaemia only fibrinogen was increased, and megaloblastic anaemia was associated with raised seromucoid level. The therapeutic result was good in all these anaemias with the exception of iron-deficiency anaemia associated with infection in which it was less propitious.

Topics: Acute-Phase Proteins; Adolescent; Adult; Aged; Anemia; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Anemia, Megaloblastic; Anemia, Sideroblastic; Female; Glucocorticoids; Humans; Iron; Male; Middle Aged; Vitamin B 12

Topics: Anemia, Hemolytic, Autoimmune; Anemia, Pernicious; Humans; Injections, Intramuscular; Lupus Erythematosus, Systemic; Male; Middle Aged; Prednisone; Vitamin B 12

Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Sideroblastic; Blood Transfusion; Female; Humans; Pregnancy; Pregnancy Complications, Hematologic; Vitamin B 12

The facts known today about the occurrence and possible mechanisms of anaemias caused by medicaments are represented in a survey. In this connection toxic haemolytic anaemias, immunohaemolytic anaemias, toxic aplastic anaemias, megaloblastic anaemias, and some other, more rarely occurring types are referred to.

Topics: Alcoholism; Anemia; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Megaloblastic; Anemia, Sideroblastic; Antitubercular Agents; Benzenesulfonates; Bone Marrow; Chloramphenicol; Chromosome Aberrations; Contraceptives, Oral, Hormonal; Folic Acid Antagonists; Gastrointestinal Hemorrhage; Humans; Preleukemia; Purines; Pyrimidines; Vitamin B 12

Topics: Anemia, Hemolytic, Autoimmune; Anemia, Pernicious; Anthraquinones; Bone Marrow; Bone Marrow Cells; Coenzyme A; Cytoplasm; Erythrocytes, Abnormal; Fluorescent Dyes; Folic Acid Deficiency; Humans; Leukemia, Erythroblastic, Acute; Megaloblasts; Microscopy, Fluorescence; NADP; Staining and Labeling; Vitamin B 12

Topics: Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Anemia, Macrocytic; Antibodies; Cell Survival; Cobalt Isotopes; Diagnosis, Differential; Erythrocytes; Feces; Female; Folic Acid; Gastric Juice; Hematologic Diseases; Hemorrhage; Humans; Intrinsic Factor; Iron; Iron Isotopes; Plasma Volume; Radioimmunoassay; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Schilling Test; Spleen; Vitamin B 12; Whole-Body Counting

Topics: Anemia, Hemolytic, Autoimmune; Basophils; Blood Platelet Disorders; Bone Marrow; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Female; Humans; Karyotyping; Leukemia, Myeloid; Leukocytosis; Middle Aged; Primary Myelofibrosis; Vitamin B 12