vitamin-b-12 and Anaphylaxis

Topics: Adult; Anaphylaxis; Humans; Hydroxocobalamin; Male; Multiple Sclerosis; Vitamin B 12; Vitamin B 12 Deficiency

We report the case of a pregnant woman who suffered from hypotension after first exposure to intravenous administration of a combination drug containing vitamins B1, B6 and B12 (Vitamedin; Daiichi-Sankyo, Tokyo, Japan). A 27-year-old Japanese woman received an intravenous infusion of fluid containing a vitamin B complex due to hyperemesis gravidarum. Thirty minutes after the start of infusion she was found to be in hypotension. The patient had stupor, general sweating, blood pressure of 82/50 mmHg, and low percutaneous oxygen saturation (SpO(2)) of 88%. We immediately stopped the infusion, lifted her legs and administered oxygen. Three minutes after these treatments, she quickly recovered to a good general condition. A skin prick test for vitamin B12 was positive, but tests for B1, B6, mannitol and saline were negative, indicating this adverse reaction was one of drug hypersensitivity due to the vitamin B12 in Vitamedin. Patients should be observed carefully immediately after the administration of Vitamedin.

Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Skin Tests; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex

We report a case of anaphylactic reaction to intramuscular injection of cyanocobalamin. This 52-year-old lady was diagnosed as a case of megaloblastic anemia secondary to dietary vitamin B12 deficiency. She had severe anaphylactic reaction after the parenteral administration of cyanocobalamine. Later she received oral vitamin B12 with no adverse effects. The purpose of this case report is to draw attention to the hypersensitive reaction to injectable vitamin B12, which is rarely seen. This could be due to sensitization to the vitamin B12 molecule itself or an IgE mediated reaction. We concluded that anaphylactic reaction to vitamin B12 is a rare but serious side effect and it should be kept in mind while the drug is being administered to the patient, especially via the parenteral route.

Topics: Anaphylaxis; Anemia, Megaloblastic; Female; Humans; Injections, Intramuscular; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Anaphylaxis; Female; Humans; Retreatment; Vitamin B 12

Topics: Adult; Anaphylaxis; Female; Humans; Hydroxocobalamin; Vitamin B 12

Human urine samples, purified on octadecasilyl-silica cartridges, contained immunoreactive angiotensin I, II, arginine vasopressin and oxytocin. The daily excretion of these peptides in healthy volunteers was 190.00 +/- 38.43 (n = 12), 17.48 +/- 3.09 (n = 12), 63.43 +/- 14.84 (n = 8) and 13.52 +/- 1.42 (n = 7) pmol/24 hr, respectively (mean +/- s.e.m.). Patients with a history of anaphylactoid reactions to drugs or food additives showed clinical symptoms such as urticaria, flush, nausea, dizziness and hypotension after oral provocation with cyanocobalamine, propyphenazone, acetylsalicylic acid and sodium benzoate. In five of the seven patients, angiotensin I and II were increased several fold in the urine fractions after symptoms were reported. The average increase in the urine concentration of both peptides was fourfold and 5.5-fold. In three out of five patients, the mean excretion of arginine vasopressin and oxytocin immunoreactive material was also elevated by a factor of 5.7 and 4.4, respectively. Oral provocation with a placebo failed to elicit anaphylactoid symptoms or an increase in the urine levels of angiotensin I or angiotensin II. Angiotensin I and angiotensin II-like immunoreactivity could be characterized on HPLC as Ile5-angiotensin I, Ile5-angiotensin II and angiotensin II metabolites. HPLC characterization of immunoreactive arginine vasopressin and oxytocin in two different gradient systems showed retention times different than the retention times of the corresponding synthetic standard peptides indicating that both peptides are not authentic AVP and OXT. These results suggest that angiotensin I and angiotensin II may be involved in the clinical events observed during some forms of anaphylactoid reactions.

Topics: Adult; Anaphylaxis; Angiotensin I; Angiotensin II; Antipyrine; Arginine Vasopressin; Aspirin; Benzoates; Benzoic Acid; Female; Humans; Male; Middle Aged; Oxytocin; Vitamin B 12

Topics: Anaphylaxis; Humans; Male; Middle Aged; Psoriasis; Vitamin B 12

Topics: Acute Kidney Injury; Adolescent; Adult; Anaphylaxis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pyrazoles; Radiculopathy; Thiamine; Vitamin B 12

Topics: Aged; Anaphylaxis; Anemia, Pernicious; Drug Hypersensitivity; Female; Humans; Injections, Intramuscular; Vitamin B 12

A case of vitamin B12 allergy is reported. Typical eczematous and exanthematic skin lesions appeared after long-term and high-dosed intake of a vitamin B12 drug (Biovital). Patch tests with vitamin B12 were positive. This observation of vitamin B12 allergy we compared with previous published cases.

Topics: Anaphylaxis; Chemical Phenomena; Chemistry; Drug Eruptions; Drug Hypersensitivity; Eczema; Female; Humans; Long-Term Care; Male; Middle Aged; Nausea; Urticaria; Vitamin B 12

Topics: Anaphylaxis; Coma; Humans; Injections, Intramuscular; Male; Middle Aged; Vitamin B 12

Topics: Aged; Anaphylaxis; Anemia, Pernicious; Humans; Hydroxocobalamin; Injections, Intramuscular; Male; Skin Tests; Vitamin B 12

Topics: Anaphylaxis; Animals; Antibody Formation; Cortisone; Depression, Chemical; Guinea Pigs; Hydrocortisone; Lipid Metabolism; Lipotropic Agents; Liver; Mice; Rabbits; Rats; Vitamin B 12

Topics: Anaphylaxis; Animals; Blood Proteins; Carbon Isotopes; Chemistry Techniques, Analytical; Cobalt Isotopes; Corrinoids; Dextrans; Dogs; Insulin; Inulin; Iodine Isotopes; Kidney; Kidneys, Artificial; Macromolecular Substances; Mice; Molecular Weight; Permeability; Research; Serum Albumin; Serum Albumin, Radio-Iodinated; Spectrophotometry; Tritium; Vitamin B 12

Topics: Abortion, Induced; Abortion, Spontaneous; Anaphylaxis; Female; Humans; Pregnancy; Vitamin B 12; Vitamins

Topics: Anaphylaxis; Anemia; Anemia, Pernicious; Corrinoids; Humans; Hypersensitivity; Liver; Vitamin B 12; Vitamins

Topics: Anaphylaxis; Anemia; Anemia, Pernicious; Corrinoids; Humans; Hypersensitivity; Vitamin B 12

Topics: Anaphylaxis; Corrinoids; Humans; Hypersensitivity; Immune System Diseases; Vitamin B 12; Vitamin B Complex