vitamin-b-12 and Alcoholic-Intoxication

Maternal ethanol consumption during pregnancy can induce developmental defects in the fetus. The objective of this study was to assess whether combined supplementation of folic acid (FA) and Vitamin B(12) (VB(12)) in dams would suppress ethanol-induced developmental toxicity in CD-1 mice. Ethanol (5.0 g/kg) was given intragastrically from gestational day (GD) 6 to GD15. Vitamin supplementation groups were additionally given 60.0 mg/kg FA, 1.0 mg/kg VB(12), or 60.0 mg/kg FA+1.0 mg/kg VB(12) during GD1-16. The control group received distilled water only. Results of litter evaluation on GD18 showed that combined supplementation of FA and VB(12) ameliorated many of the adverse effects of ethanol. In contrast, the single vitamin supplementation groups showed little or no amelioration. These results suggest that combined supplementation of FA and VB(12) was more effective than each vitamin toward suppressing ethanol-induced developmental toxicity in CD-1 mice.

Topics: Abnormalities, Drug-Induced; Alcoholic Intoxication; Animals; Bone and Bones; Dietary Supplements; Embryo Implantation; Embryo Loss; Ethanol; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Mice; Pregnancy; Vitamin B 12

Topics: Adult; Alcoholic Intoxication; Alcoholism; Blood Chemical Analysis; Bone Marrow Examination; Folic Acid; Hematopoiesis; Humans; Iron; Iron Isotopes; Liver Function Tests; Male; Middle Aged; Vitamin B 12

Topics: Alcoholic Intoxication; Alcoholism; Anemia; Aspartic Acid; Asthenia; Humans; Liver Cirrhosis; Liver Diseases; Liver Extracts; Magnesium; Nutrition Disorders; Postoperative Care; Potassium; Vitamin B 12; Yeast, Dried