vitamin-b-12 and Acromegaly

vitamin-b-12 has been researched along with Acromegaly* in 2 studies

Other Studies

2 other study(ies) available for vitamin-b-12 and Acromegaly

Article	Year
Reversible leukoencephalopathy due to vitamin B12 deficiency in an acromegalic patient. Journal of neurology, 2003, Volume: 250, Issue:3 Topics: Acromegaly; Adult; Brain; Dementia, Vascular; Female; Humans; Magnetic Resonance Imaging; Vitamin B 12; Vitamin B 12 Deficiency	2003
Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly. The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:6 Gastrointestinal side-effects of prolonged therapy (greater than 2 yr) with the long-acting somatostatin analog octreotide were studied in 10 acromegalic patients. After 2 yr of therapy, 6 of 10 patients had newly developed gallstones, complicated by cholangitis and jaundice in 1. Serum vitamin B-12 concentrations declined in all 10 patients [from 380 +/- 32 to 172 +/- 21 pmol/L (mean +/- SE); P = 0.023] and became abnormally low in 4. Gastric biopsy specimens, obtained during gastroscopy (9 patients), showed moderate to severe active gastritis, with damage to the superficial and deeper layers of the mucosa in 9 of 9 and focal atrophy in 7 of 9 patients. Campylobacter pylori was found in the antral mucosa in 8 of 9 patients. Although information is lacking on similar studies in untreated acromegalic patients, we suggest that patients receiving chronic octreotide therapy be closely monitored for these and possible other side-effects related to gastrointestinal actions of octreotide. Topics: Acromegaly; Adult; Aged; Atrophy; Cholelithiasis; Epithelium; Female; Gastric Mucosa; Gastritis; Gastrointestinal Diseases; Helicobacter pylori; Humans; Male; Middle Aged; Octreotide; Vitamin B 12	1990

Article

Year

Reversible leukoencephalopathy due to vitamin B12 deficiency in an acromegalic patient.

Journal of neurology, 2003, Volume: 250, Issue:3

Topics: Acromegaly; Adult; Brain; Dementia, Vascular; Female; Humans; Magnetic Resonance Imaging; Vitamin B 12; Vitamin B 12 Deficiency

2003

Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly.

The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:6

Gastrointestinal side-effects of prolonged therapy (greater than 2 yr) with the long-acting somatostatin analog octreotide were studied in 10 acromegalic patients. After 2 yr of therapy, 6 of 10 patients had newly developed gallstones, complicated by cholangitis and jaundice in 1. Serum vitamin B-12 concentrations declined in all 10 patients [from 380 +/- 32 to 172 +/- 21 pmol/L (mean +/- SE); P = 0.023] and became abnormally low in 4. Gastric biopsy specimens, obtained during gastroscopy (9 patients), showed moderate to severe active gastritis, with damage to the superficial and deeper layers of the mucosa in 9 of 9 and focal atrophy in 7 of 9 patients. Campylobacter pylori was found in the antral mucosa in 8 of 9 patients. Although information is lacking on similar studies in untreated acromegalic patients, we suggest that patients receiving chronic octreotide therapy be closely monitored for these and possible other side-effects related to gastrointestinal actions of octreotide.

Topics: Acromegaly; Adult; Aged; Atrophy; Cholelithiasis; Epithelium; Female; Gastric Mucosa; Gastritis; Gastrointestinal Diseases; Helicobacter pylori; Humans; Male; Middle Aged; Octreotide; Vitamin B 12

1990