vitamin-b-12 and Acneiform-Eruptions

We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. or oral vitamin B12. Clinical picture was characterized by papules and pustules located on the face. In three patients, similar lesions were also present on the neck, shoulders, chest, and upper portion of the back. Comedones and cysts were absent. In two patients, serum vitamin B12 levels were very high. Histopathologic examination in one patient revealed an eosinophilic folliculitis. Spontaneous and complete remission was observed in all patients 3-6 weeks after vitamin B12 discontinuation.

Topics: Acneiform Eruptions; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Female; Humans; Middle Aged; Prognosis; Remission, Spontaneous; Risk Assessment; Vitamin B 12; Withholding Treatment; Young Adult

Topics: Acneiform Eruptions; Dermatitis, Exfoliative; Drug Eruptions; Humans; Vitamin B 12; Vitamins

Drug-induced acne is a specific subset of acne that usually has some specific features, namely monomorphic pattern, unusual location of the lesions beyond the seborrheic areas, uncommon age of onset, a resistance to conventional acne treatment. Several drugs have been associated with the development of eruptions that may simulate acne vulgaris. However, so far, there are a few cases of vitamin B12-induced acne. We report a case of acneiform eruption induced by vitamin B12 injection in a 37-year-old female patient.

Topics: Acneiform Eruptions; Adult; Drug Eruptions; Female; Humans; Vitamin B 12; Vitamin B Complex

Topics: Acneiform Eruptions; Adapalene; Adult; Benzoyl Peroxide; Brain Damage, Chronic; Brain Injuries; Clindamycin; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Lymecycline; Male; Naphthalenes; Vitamin B 12