vitamin-b-12 and Abscess

Bariatric surgery aims at weight reduction of severely obese patients. The Roux-en-Y technique is one of the most common bariatric procedures and is occasionally accompanied by nutrient insufficiencies and metabolic changes. According to the literature, skin architecture and immunity change after bariatric surgery and may lead to inflammation and increased susceptibility to pathogens. Additionally, vitamin and mineral deficiencies frequently develop in these patients and affect the skin's defense mechanisms, possibly contributing to dermatological complications. Knowledge and recognition of skin changes after bariatric surgery make an important asset for the dermatologist and help in the proper treatment of these patients. We report 2 cases of infectious skin lesions where vitamin and trace element deficiencies have possibly contributed to their persistence and resistance to traditional treatments.

Topics: Abscess; Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Calcium; Female; Gastric Bypass; Humans; Leg Ulcer; Middle Aged; Obesity, Morbid; Pseudomonas aeruginosa; Pseudomonas Infections; Recurrence; Skin Diseases, Bacterial; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D; Vitamin D Deficiency; Zinc

Topics: Abscess; Acute Disease; Antiviral Agents; Child; Ear Diseases; Electromyography; Facial Paralysis; Humans; Hypertension; Leukemia; Magnetic Resonance Imaging; Neoplasms; Neurophysiology; Radionuclide Imaging; Steroids; Virus Diseases; Vitamin B 12

Combined medullary sclerosis developed suddenly postoperatively in a patient with unknown Biermer's disease. The neurological lesions were undoubtedly induced by nitrogen protoxide via an inactivation of vitamin B12.

Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Abscess; Aged; Anemia, Pernicious; Anesthetics, Inhalation; Arthroplasty, Replacement, Hip; Atrophy; Autoantibodies; Autoimmune Diseases; Demyelinating Diseases; Female; Gastric Mucosa; Humans; Intestinal Absorption; Intrinsic Factor; Nitrous Oxide; Oxidation-Reduction; Paresthesia; Postoperative Complications; Proprioception; S-Adenosylmethionine; Sclerosis; Spinal Cord; Spinal Cord Diseases; Surgical Wound Infection; Vitamin B 12

The present studies document the cellular and biochemical processes involved in granulocyte O2- production in three patients from two kindreds with variant chronic granulomatous disease (CGD). Rates of O2- production were 9% to 30% of normal, depending on the individual tested and the stimulus; the two brothers from one family responded to each stimulus with rates very similar to each other. Kinetic analysis of NADPH-dependent O2- production in subcellular fractions revealed all three to have NADPH oxidases with both diminished substrate affinity for NADPH (high Kmapp) and decreased maximal velocities of O2- production. Their granulocytes had normal lag times for activation of the respiratory burst but abnormal rates of stimulus-induced membrane depolarization. Cytochrome b was not found in granulocytes or subcellular fractions despite the use of a spectrophotometric assay sensitive enough to detect the cytochrome if its content were proportional to the residual rate of O2- generation. A striking finding in one patient from each kindred was a threefold to tenfold decrease in the rate of O2- production accompanying serious infection. The residual O2(-)-generating activity of CGD variants helps to explain their relative freedom from the recurrent infections of the classic disease. However, the marked decrease described in the present study indicates the potential for a vicious cycle in which an infection, once established, leads to increasing impairment of host defense.

Topics: Abscess; Aspergillosis; Cell Compartmentation; Cytochrome b Group; Flavoproteins; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Membrane Potentials; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Pedigree; Peroxidase; Superoxides; Vitamin B 12

Topics: Abscess; Animals; Clostridium Infections; Horse Diseases; Horses; Injections, Intramuscular; Male; Neck; Penicillin G; Vitamin B 12