vinorelbine and Disease-Models--Animal

vinorelbine has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for vinorelbine and Disease-Models--Animal

Article	Year
Synthesis and SAR of vinca alkaloid analogues. Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4 Versatile intermediates 12'-iodovinblastine, 12'-iodovincristine and 11'-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell toxicity assays is presented. Selected analogues 27 and 36 show promising anticancer activity in the P388 murine leukemia model. Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Vinblastine; Vinca Alkaloids; Vincristine	2009

Article

Year

Synthesis and SAR of vinca alkaloid analogues.

Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4

Versatile intermediates 12'-iodovinblastine, 12'-iodovincristine and 11'-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell toxicity assays is presented. Selected analogues 27 and 36 show promising anticancer activity in the P388 murine leukemia model.

Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Vinblastine; Vinca Alkaloids; Vincristine

2009