vincristine-sulfate and Ovarian-Neoplasms

vincristine-sulfate has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for vincristine-sulfate and Ovarian-Neoplasms

Article	Year
Substituted E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity. Effect on the cell cycle and apoptosis. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 The synthesis and antitumor activity of new E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones is described. They were studied at the National Cancer Institute, taking into consideration the 50% growth inhibitory power (pGI50), the cytostatic effect (pTGI = total growth inhibition), and the cytotoxic effect (pLC50). All the compounds were potent growth inhibitors, with mean pGI50 ranging from 5.26 to 7.72. They were also analyzed with NCI COMPARE algorithm. Further studies were dedicated to the effects on the cell cycle and apoptosis. Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Magnetic Resonance Spectroscopy; Ovarian Neoplasms	2007

Article

Year

Substituted E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity. Effect on the cell cycle and apoptosis.

Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14

The synthesis and antitumor activity of new E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones is described. They were studied at the National Cancer Institute, taking into consideration the 50% growth inhibitory power (pGI50), the cytostatic effect (pTGI = total growth inhibition), and the cytotoxic effect (pLC50). All the compounds were potent growth inhibitors, with mean pGI50 ranging from 5.26 to 7.72. They were also analyzed with NCI COMPARE algorithm. Further studies were dedicated to the effects on the cell cycle and apoptosis.

Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Magnetic Resonance Spectroscopy; Ovarian Neoplasms

2007