vincristine-sulfate and Breast-Neoplasms

vincristine-sulfate has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for vincristine-sulfate and Breast-Neoplasms

Article	Year
Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells. Journal of medicinal chemistry, 2010, Aug-12, Volume: 53, Issue:15 The synthesis of new substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones is reported. The antitumor activity was evaluated according to protocols available at the National Cancer Institute (NCI), Bethesda, MD. Structure-activity relationships are discussed. The action of selected compounds was investigated in MCF-7 breast cancer cells. The ability of these derivatives to inhibit cellular proliferation was accompanied by increased level of p53 and its transcriptional targets p21 and Bax, interference in the cell cycle progression with cell accumulation in the G2/M phase, and activation of apoptosis. Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytostatic Agents; Cytotoxins; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Stereoisomerism; Structure-Activity Relationship; Tumor Suppressor Protein p53	2010

Article

Year

Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

Journal of medicinal chemistry, 2010, Aug-12, Volume: 53, Issue:15

The synthesis of new substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones is reported. The antitumor activity was evaluated according to protocols available at the National Cancer Institute (NCI), Bethesda, MD. Structure-activity relationships are discussed. The action of selected compounds was investigated in MCF-7 breast cancer cells. The ability of these derivatives to inhibit cellular proliferation was accompanied by increased level of p53 and its transcriptional targets p21 and Bax, interference in the cell cycle progression with cell accumulation in the G2/M phase, and activation of apoptosis.

Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytostatic Agents; Cytotoxins; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Stereoisomerism; Structure-Activity Relationship; Tumor Suppressor Protein p53

2010