viloxazine has been researched along with Epilepsy in 8 studies
Viloxazine: A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC." | 6.67 | Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994) |
| " for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC." | 2.67 | Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| " Clearance and volume of distribution calculated after IV dosing in the patients were 124 +/- 11 ml h-1 kg-1 and 0." | 1.27 | Pharmacokinetics of the antidepressant drug viloxazine in normal subjects and in epileptic patients receiving chronic anticonvulsant treatment. ( Artesi, C; Fazio, A; Perucca, E; Pisani, B; Pisani, F; Russo, M; Spina, E; Trio, R, 1986) |
| " Pharmacokinetic studies in the mouse showed peak plasma levels to occur 30 min following oral doses, with a mean half-life of 58 min." | 1.26 | Anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. ( Adam, HK; Anlezark, GM; Greenwood, DT; Meldrum, BS, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Pisani, F | 5 |
| Narbone, MC | 1 |
| Fazio, A | 5 |
| Crisafulli, P | 1 |
| Primerano, G | 1 |
| D'Agostino, AA | 1 |
| Oteri, G | 4 |
| Di Perri, R | 4 |
| Meldrum, BS | 1 |
| Anlezark, GM | 1 |
| Adam, HK | 1 |
| Greenwood, DT | 1 |
| Artesi, C | 3 |
| Xiao, B | 1 |
| Perucca, E | 4 |
| Trimble, M | 1 |
| Russo, M | 3 |
| Trio, R | 3 |
| Spina, E | 1 |
| Pisani, B | 2 |
1 review available for viloxazine and Epilepsy
| Article | Year |
|---|---|
Non-monoamine oxidase inhibitor antidepressants and epilepsy: a review.
Topics: Adult; Aged; Amines; Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricycl | 1978 |
1 trial available for viloxazine and Epilepsy
| Article | Year |
|---|---|
Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Depressive Disorder; Double-Blind Method; | 1994 |
6 other studies available for viloxazine and Epilepsy
| Article | Year |
|---|---|
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Effect of viloxazine on serum carbamazepine levels in epileptic patients.
Topics: Adult; Carbamazepine; Depression; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Mo | 1984 |
Anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy; Female; Kinetic | 1982 |
Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction.
Topics: Adult; Aged; Depressive Disorder; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Ph | 1992 |
Pharmacokinetics of the antidepressant drug viloxazine in normal subjects and in epileptic patients receiving chronic anticonvulsant treatment.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Drug Interactions; Epilepsy; Female; Humans; Injectio | 1986 |
Carbamazepine-viloxazine interaction in patients with epilepsy.
Topics: Adult; Carbamazepine; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Epilepsy; F | 1986 |