vigabatrin has been researched along with Syndrome in 16 studies
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This systematic review and meta-analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS)." | 9.41 | Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis. ( Chang, X; Gong, P; Jiao, X; Niu, Y; Wu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| "To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)." | 8.31 | Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023) |
| "In our patient, seizures immediately stopped upon initiation of vigabatrin treatment, and his development and neurological examination at one year are normal." | 7.78 | Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin. ( Fluss, J; Korff, CM; Picard, F; Vulliemoz, S, 2012) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 7.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "This systematic review and meta-analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS)." | 5.41 | Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis. ( Chang, X; Gong, P; Jiao, X; Niu, Y; Wu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| "Vigabatrin dose was 25-114 mg/kg/day (mean 55." | 5.31 | Vigabatrin associated retinal dysfunction in children with epilepsy. ( Al Riyami, K; Bulusu, S; Chacko, A; Ganesh, A; Koul, R, 2001) |
| "To describe the temporal trends in the cost and use of adrenocorticotropic hormone (ACTH), oral prednisolone, and vigabatrin, the first-line treatments for infantile epileptic spasms syndrome (IESS)." | 4.31 | Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome. ( Amengual-Gual, M; Barcia Aguilar, C; Chao, J; Douglass, L; Gaínza-Lein, M; Harini, C; Jonas, R; Romeu, A; Sánchez Fernández, I; Sheikh, T; Torres, A, 2023) |
| "To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)." | 4.31 | Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023) |
| "In our patient, seizures immediately stopped upon initiation of vigabatrin treatment, and his development and neurological examination at one year are normal." | 3.78 | Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin. ( Fluss, J; Korff, CM; Picard, F; Vulliemoz, S, 2012) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 3.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy." | 3.69 | Vigabatrin monotherapy in resistant neonatal seizures. ( Barwick, DD; Baxter, PS; Gardner-Medwin, D; Ince, P; Livingston, J; Murdoch-Eaton, D, 1995) |
| "Vigabatrin dose was 25-114 mg/kg/day (mean 55." | 1.31 | Vigabatrin associated retinal dysfunction in children with epilepsy. ( Al Riyami, K; Bulusu, S; Chacko, A; Ganesh, A; Koul, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 8 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramantani, G | 1 |
| Bölsterli, BK | 2 |
| Alber, M | 1 |
| Klepper, J | 1 |
| Korinthenberg, R | 1 |
| Kurlemann, G | 1 |
| Tibussek, D | 1 |
| Wolff, M | 1 |
| Schmitt, B | 3 |
| Sánchez Fernández, I | 1 |
| Amengual-Gual, M | 1 |
| Barcia Aguilar, C | 1 |
| Romeu, A | 1 |
| Sheikh, T | 1 |
| Torres, A | 1 |
| Chao, J | 1 |
| Jonas, R | 1 |
| Gaínza-Lein, M | 1 |
| Harini, C | 1 |
| Douglass, L | 1 |
| Osborne, JP | 1 |
| Edwards, SW | 1 |
| Alber, FD | 1 |
| Hancock, E | 1 |
| Johnson, AL | 1 |
| Kennedy, CR | 1 |
| Likeman, M | 1 |
| Lux, AL | 1 |
| Mackay, M | 1 |
| Mallick, A | 1 |
| Newton, RW | 1 |
| Nolan, M | 1 |
| Pressler, R | 1 |
| Rating, D | 1 |
| Verity, CM | 1 |
| O'Callaghan, FK | 1 |
| Xu, Z | 1 |
| Gong, P | 1 |
| Jiao, X | 1 |
| Niu, Y | 1 |
| Wu, Y | 1 |
| Zhang, Y | 1 |
| Chang, X | 1 |
| Yang, Z | 1 |
| Lal, P | 1 |
| Sahu, JK | 1 |
| Heinrich, B | 1 |
| Critelli, H | 1 |
| Huber, R | 1 |
| Fattinger, S | 1 |
| von Hardenberg, S | 1 |
| Richter, MF | 1 |
| Hethey, S | 1 |
| Yaspo, ML | 1 |
| Auber, B | 1 |
| Schlegelberger, B | 1 |
| Illig, T | 1 |
| Guthmann, F | 1 |
| Christen, HJ | 1 |
| Ripperger, T | 1 |
| Bergmann, AK | 1 |
| Weckhuysen, S | 1 |
| Tajsharghi, H | 1 |
| Cazorla, MR | 1 |
| Verdú, A | 1 |
| Montes, C | 1 |
| Ayuga, F | 1 |
| Korff, CM | 1 |
| Vulliemoz, S | 1 |
| Picard, F | 1 |
| Fluss, J | 1 |
| Krsek, P | 1 |
| Sebronová, V | 1 |
| Procházka, T | 1 |
| Maulisová, A | 1 |
| Komárek, V | 1 |
| Chau, V | 1 |
| Karvelas, G | 1 |
| Jacob, P | 1 |
| Carmant, L | 2 |
| Lahat, E | 1 |
| Baxter, PS | 1 |
| Gardner-Medwin, D | 1 |
| Barwick, DD | 1 |
| Ince, P | 1 |
| Livingston, J | 1 |
| Murdoch-Eaton, D | 1 |
| Bélanger, S | 1 |
| Coulombe, G | 1 |
| Koul, R | 1 |
| Chacko, A | 1 |
| Ganesh, A | 1 |
| Bulusu, S | 1 |
| Al Riyami, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for vigabatrin and Syndrome
| Article | Year |
|---|---|
Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis.
Topics: Anticonvulsants; Humans; Spasm; Spasms, Infantile; Syndrome; Vigabatrin | 2023 |
[Vigabatrin in the treatment of pediatric epileptic syndrome].
Topics: Anticonvulsants; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Syndrome; Vigabatrin | 1995 |
14 other studies available for vigabatrin and Syndrome
| Article | Year |
|---|---|
Treatment of Infantile Spasm Syndrome: Update from the Interdisciplinary Guideline Committee Coordinated by the German-Speaking Society of Neuropediatrics.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Epilepsy; Humans; Infant; Spasms, Infantile; Syndrome; | 2022 |
Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Female; Humans; Infant; Infant, Newborn; Male; | 2023 |
Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials.
Topics: Anticonvulsants; Cosyntropin; Epilepsy; Humans; Infant; Prednisolone; Randomized Controlled Trials a | 2023 |
What Should be the Next Choice After Failure of Hormonal and Vigabatrin Therapy in Infantile Epileptic Spasms Syndrome?
Topics: Anticonvulsants; Humans; Infant; Spasm; Spasms, Infantile; Syndrome; Treatment Outcome; Vigabatrin | 2023 |
Disparate effects of hormones and vigabatrin on sleep slow waves in patients with West syndrome - An indication of their mode of action?
Topics: Anticonvulsants; Electroencephalography; Female; Hormones; Humans; Infant; Longitudinal Studies; Mal | 2021 |
Rational therapy with vigabatrin and a ketogenic diet in a patient with GAD1 deficiency.
Topics: Diet, Ketogenic; Epilepsy, Generalized; Humans; Infant, Newborn; Mental Disorders; Syndrome; Vigabat | 2020 |
Reply: Rational therapy with vigabatrin and a ketogenic diet in a patient with GAD1 deficiency.
Topics: Diet, Ketogenic; Epilepsy, Generalized; Humans; Infant, Newborn; Mental Disorders; Syndrome; Vigabat | 2020 |
Early infantile epileptic encephalopathy with unusual favourable outcome.
Topics: Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Pre | 2010 |
Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin.
Topics: Anticonvulsants; Carbamazepine; Drug Resistance; Electroencephalography; Humans; Infant; Male; Neuro | 2012 |
Successful treatment of Ohtahara syndrome with chloral hydrate.
Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans; | 2002 |
Early treatment of Aicardi syndrome with vigabatrin can improve outcome.
Topics: Anticonvulsants; Corpus Callosum; Female; Humans; Infant; Magnetic Resonance Imaging; Spasms, Infant | 2004 |
Vigabatrin monotherapy in resistant neonatal seizures.
Topics: Agenesis of Corpus Callosum; Anticonvulsants; Atrophy; Brain; Cerebral Cortex; Dose-Response Relatio | 1995 |
Role of vigabatrin and lamotrigine in treatment of childhood epileptic syndromes.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1998 |
Vigabatrin associated retinal dysfunction in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Evoked Po | 2001 |