vigabatrin has been researched along with Status Epilepticus in 14 studies
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "The present study compares the efficacy of carbamazepine (20 mg/kg/day) and vigabatrin (250 mg/kg/day) in preventing hippocampal and amygdaloid damage in the perforant pathway stimulation model of status epilepticus in the rat." | 7.69 | Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala. ( Halonen, T; Pitkänen, A; Tuunanen, J, 1996) |
| "Vigabatrin treatment was started either 1 h, or 2 or 7 days after the beginning of kainic acid-induced (9 mg/kg, i." | 5.30 | Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus. ( Halonen, T; Jolkkonen, E; Nissinen, J; Pitkänen, A; Tuunanen, J, 1999) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "Vigabatrin (VGB) treatment is neuroprotective in various models of status epilepticus (SE) and delays the development of kindling via mechanisms that are assumed to relate to the elevation of GABA levels in the brain." | 3.71 | Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats. ( Halonen, T; Nissinen, J; Pitkänen, A, 2001) |
| "We studied the neuroprotective effect of vigabatrin (gamma-vinyl GABA, VGB) in the rat hippocampus after status epilepticus (SE) induced by kainic acid (KA)." | 3.69 | Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus. ( Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J, 1995) |
| "The present study compares the efficacy of carbamazepine (20 mg/kg/day) and vigabatrin (250 mg/kg/day) in preventing hippocampal and amygdaloid damage in the perforant pathway stimulation model of status epilepticus in the rat." | 3.69 | Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala. ( Halonen, T; Pitkänen, A; Tuunanen, J, 1996) |
| "The metabolism of GABA and other amino acids was studied in the substantia nigra, the hippocampus and the parietal cortex of rats following microinjections of GAMMA-vinyl-GABA during status epilepticus induced by lithium and pilocarpine." | 3.68 | GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus. ( Baldwin, RA; Baxter, CF; Wasterlain, CG, 1993) |
| "Vigabatrin treatment was started either 1 h, or 2 or 7 days after the beginning of kainic acid-induced (9 mg/kg, i." | 1.30 | Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus. ( Halonen, T; Jolkkonen, E; Nissinen, J; Pitkänen, A; Tuunanen, J, 1999) |
| "Kainic acid (KA)-induced convulsions are accompanied by histopathological changes that are most prominent in the temporal lobe structures." | 1.29 | Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. ( Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pereira, MB | 1 |
| Freitas, RL | 1 |
| Assis, MA | 1 |
| Silva, RF | 1 |
| Fonteles, MM | 1 |
| Freitas, RM | 1 |
| Takahashi, RN | 1 |
| André, V | 1 |
| Dubé, C | 1 |
| François, J | 1 |
| Leroy, C | 1 |
| Rigoulot, MA | 1 |
| Roch, C | 1 |
| Namer, IJ | 1 |
| Nehlig, A | 1 |
| Halonen, T | 6 |
| Miettinen, R | 2 |
| Toppinen, A | 2 |
| Tuunanen, J | 4 |
| Kotti, T | 2 |
| Riekkinen, PJ | 2 |
| Pitkänen, A | 4 |
| de Krom, MC | 1 |
| Verduin, N | 1 |
| Visser, E | 1 |
| Kleijer, M | 1 |
| Scholtes, F | 1 |
| De Groen, JH | 1 |
| van der Zwan, A | 2 |
| Arzimanoglou, A | 1 |
| Rogers, D | 1 |
| Bird, J | 1 |
| Eames, P | 1 |
| Wasterlain, CG | 1 |
| Baxter, CF | 1 |
| Baldwin, RA | 1 |
| Vaquerizo, J | 1 |
| Romero-Rodríguez, JC | 1 |
| González-Roncero, A | 1 |
| Gómez-Marcos, A | 1 |
| Nissinen, J | 2 |
| Jolkkonen, E | 1 |
1 trial available for vigabatrin and Status Epilepticus
| Article | Year |
|---|---|
[Vigabatrin: results with a new antiepileptic agents in 57 patients in a general neurological practice].
Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Dru | 1994 |
13 other studies available for vigabatrin and Status Epilepticus
| Article | Year |
|---|---|
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; | 1995 |
Prevention of neuronal cell death by anticonvulsants in experimental epilepsy (extended abstract).
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Cell Survival; Disease Models, Animal; gam | 1995 |
Status epilepticus during vigabatrin treatment: a report of three cases.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Anticonvulsants; Brain; Electroencephalography; Epi | 1995 |
Vigabatrin and complex partial status.
Topics: Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, Complex Partial; Evoke | 1994 |
Complex partial status after starting vigabatrin.
Topics: Adult; Aged; Aminocaproates; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epi | 1993 |
GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus.
Topics: Amino Acids; Aminocaproates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Hippocampus; Lithium | 1993 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, A | 1995 |
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Electric Stimulation; gamma-Aminobutyric Acid; Hi | 1996 |
[Partial complex status epilepticus: diagnostic difficulties].
Topics: Anticonvulsants; Child; Crime; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog | 1998 |
Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus.
Topics: Animals; Anticonvulsants; Electroencephalography; Excitatory Amino Acid Agonists; gamma-Aminobutyric | 1999 |
Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats.
Topics: Animals; Anticonvulsants; Brain; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Hippocam | 2001 |