vigabatrin and Retinal Diseases studies

Research Excerpts

Excerpt	Relevance	Reference
"Vigabatrin dose was 25-114 mg/kg/day (mean 55."	5.31	Vigabatrin associated retinal dysfunction in children with epilepsy. ( Al Riyami, K; Bulusu, S; Chacko, A; Ganesh, A; Koul, R, 2001)
"Six patients with epilepsy treated with vigabatrin as add-on therapy for at least 3 years were included in this observational case series."	3.72	Retinal function abnormalities in patients treated with vigabatrin. ( Banin, E; Chowers, I; Gross-Tsur, V; Neis, R; Obolensky, A; Shalev, RS, 2003)
"Vigabatrin (VGB) has been widely used in patients affected by drug-resistant epilepsy and West syndrome."	3.72	Scotopic threshold response changes after vigabatrin therapy in a child without visual field defects: a new electroretinographic marker of early damage? ( Manfredi, M; Parisi, P; Piazza, G; Tommasini, P, 2004)
"A nonrandomly selected cohort of 8 previous and 18 current vigabatrin users and a reference cohort of 8 never vigabatrin-treated patients with epilepsy receiving other antiepilepsy drugs (AED) underwent electro-oculography (EOG), electroretinography (ERG), and automated static threshold perimetry."	3.70	Separating the retinal electrophysiologic effects of vigabatrin: treatment versus field loss. ( Harding, GF; Martinez, C; Rietbrock, S; Robertson, KA; Wild, JM, 2000)
"Taurine levels were 67% lower in vigabatrin-treated animals than in control animals."	2.74	Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity. ( Chiron, C; Collins, SD; Coriat, C; Craft, CM; Duboc, A; Dubus, E; Dulac, O; Jammoul, F; Nabbout, R; Picaud, S; Sahel, JA; Simonutti, M; Wang, Q; Ye, W, 2009)
"Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid (GABA) transaminase."	2.47	Understanding and interpreting vision safety issues with vigabatrin therapy. ( Plant, GT; Sergott, RC, 2011)
"Vigabatrin is an effective and well-tolerated antiepileptic drug (AED) for the treatment of refractory complex partial seizures (rCPS) and infantile spasms (IS), but its benefits must be evaluated in conjunction with its risk of retinopathy with the development of peripheral visual field defects (pVFDs)."	2.47	Balancing clinical benefits of vigabatrin with its associated risk of vision loss. ( Pellock, JM, 2011)
"In vigabatrin treated patients a functional or structural retinal changes may occur, what can be measured by electrophysiological and visual field testing."	2.44	[Retinal dysfunction in patients treated with vigabatrin]. ( Hampel-Osipowicz, E; Lubiński, W; Podboraczyńska-Jodkoi, K, 2007)
"Vigabatrin (VGB) is an effective antiepileptic that increases concentrations of inhibitory γ-aminobutyric acid (GABA) by inhibiting GABA transaminase."	1.56	Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. ( Chan, K; Gibson, KM; Gloe, S; Hoon, M; Jansen, E; Kiland, JA; McLellan, GJ; Pattnaik, BR; Roullet, JB; Salomons, G; Ver Hoeve, JN; Vogel, KR; Wahlgren, B; Walters, D; Wetherbee, B; Williams, J, 2020)
"OCT and complete dosing data was available for 19 patients."	1.43	Optical coherence tomography to monitor vigabatrin toxicity in children. ( Alexander, J; Bazemore, M; Berl, MM; de Beaufort, H; Elling, N; Geddie, B; Hutcheson, K; Jaafar, MS; Karwoski, B; Madigan, W; McClintock, W; Miller, M; Origlieri, C; Taylormoore, J, 2016)
"Vigabatrin (VGB), a treatment for the childhood epilepsy, infantile spasms (IS), is implicated in visual field constriction."	1.40	Changes in the ERG d-wave with vigabatrin treatment in a pediatric cohort. ( Dragas, R; Westall, C; Wright, T, 2014)
" There was neither effect of age of initiation of VGB treatment nor sex of the child on survival statistics and no significant effect of cumulative dosage on the occurrence of VGB-RD."	1.40	Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study. ( Buncic, JR; Cortese, F; Kumarappah, A; Snead, OC; Westall, CA; Wright, T, 2014)
"Introduccion."	1.39	[Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy]. ( Benavides-Lara, A; Hernández, L; Ulate-Campos, A, 2013)
"Vigabatrin (VGB) is an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase."	1.32	Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. ( Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF, 2004)
" There was no statistically significant relationship between the frequency of electrodiagnostic abnormalities and the duration of use or the total cumulative dosage of Vigabatrin in any of the three groups."	1.31	Vigabatrin effect on inner retinal function. ( Coupland, SG; Leonard, BC; Ross, TM; Zackon, DH, 2001)
"Vigabatrin dose was 25-114 mg/kg/day (mean 55."	1.31	Vigabatrin associated retinal dysfunction in children with epilepsy. ( Al Riyami, K; Bulusu, S; Chacko, A; Ganesh, A; Koul, R, 2001)
"Vigabatrin is an extremely effective antiepileptic drug that selectively increases brain gamma-aminobutyric acid (GABA)."	1.30	Vigabatrin-associated retinal cone system dysfunction: electroretinogram and ophthalmologic findings. ( Johnson, MA; Krauss, GL; Miller, NR, 1998)
"Vigabatrin acts as an inhibitor of gamma-aminobutyric acid (GABA) transaminase."	1.30	Outer retinal dysfunction in patients treated with vigabatrin. ( Arndt, CF; Defoort-Dhellemmes, S; Derambure, P; Hache, JC, 1999)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (5.13)	18.2507
2000's	21 (53.85)	29.6817
2010's	14 (35.90)	24.3611
2020's	2 (5.13)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Effect of Gabapentin on Prefrontal GABA Concentration and Emotional Processing in Healthy Humans[NCT00094510]				30 participants (Actual)	Observational	2004-10-14	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Justification of vigabatrin administration in West syndrome patients? Warranting a re-consideration for improvement in their quality of life. Clinical neurology and neurosurgery, 2009, Volume: 111, Issue:2 Topics: Anticonvulsants; Humans; Infant; Quality of Life; Retinal Diseases; Spasms, Infantile; Treatment Out	2009
Understanding and interpreting vision safety issues with vigabatrin therapy. Acta neurologica Scandinavica. Supplementum, 2011, Issue:192 Topics: 4-Aminobutyrate Transaminase; Adult; Animals; Anticonvulsants; Causality; Comorbidity; Confounding F	2011
Balancing clinical benefits of vigabatrin with its associated risk of vision loss. Acta neurologica Scandinavica. Supplementum, 2011, Issue:192 Topics: Adult; Animals; Anticonvulsants; Child; Epilepsies, Partial; Humans; Infant; Magnetic Resonance Imag	2011
Vigabatrin-associated retinal damage: potential biochemical mechanisms. Acta neurologica Scandinavica, 2012, Volume: 126, Issue:4 Topics: Animals; Anticonvulsants; Epilepsy; Humans; Retinal Diseases; Taurine; Vigabatrin	2012
[Retinal dysfunction in patients treated with vigabatrin]. Klinika oczna, 2007, Volume: 109, Issue:1-3 Topics: Anticonvulsants; Electrooculography; Electroretinography; Humans; Retina; Retinal Diseases; Vigabatr	2007
[Vigabatrin: balancing effectiveness vs. (irreversible) visual field loss as a side effect]. Nederlands tijdschrift voor geneeskunde, 2000, Oct-21, Volume: 144, Issue:43 Topics: 4-Aminobutyrate Transaminase; Anticonvulsants; Contraindications; Enzyme Inhibitors; Epilepsy; Human	2000

Article	Year
Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity. Annals of neurology, 2009, Volume: 65, Issue:1 Topics: Amino Acids; Analysis of Variance; Animals; Child, Preschool; Disease Models, Animal; Dose-Response	2009
Peripheral retinal dysfunction in patients taking vigabatrin. Neurology, 2003, Dec-23, Volume: 61, Issue:12 Topics: Adult; Aged; Cohort Studies; Color Perception; Dose-Response Relationship, Drug; Electroretinography	2003

Article	Year
Retinal defect in children with infantile spasms of varying etiologies: An observational study. Neurology, 2020, 02-11, Volume: 94, Issue:6 Topics: Anticonvulsants; Child, Preschool; Electroretinography; Female; Genetic Diseases, Inborn; Humans; Hy	2020
Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. Investigative ophthalmology & visual science, 2020, 02-07, Volume: 61, Issue:2 Topics: Animals; Anticonvulsants; GABA Agents; Male; Mice, Inbred C57BL; Neuronal Plasticity; Oculomotor Mus	2020
[Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy]. Revista de neurologia, 2013, Dec-01, Volume: 57, Issue:11 Topics: Anticonvulsants; Autistic Disorder; Brain Diseases; Brain Neoplasms; Child, Preschool; Comorbidity;	2013
Changes in the ERG d-wave with vigabatrin treatment in a pediatric cohort. Documenta ophthalmologica. Advances in ophthalmology, 2014, Volume: 129, Issue:2 Topics: Anticonvulsants; Child; Child, Preschool; Electroretinography; Female; Humans; Infant; Male; Photic	2014
Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study. Neurology, 2014, Dec-09, Volume: 83, Issue:24 Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Electroretinography; Female; Follow-Up Stu	2014
Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study. Neurology, 2015, Aug-18, Volume: 85, Issue:7 Topics: Anticonvulsants; Female; Humans; Male; Retinal Diseases; Spasms, Infantile; Vigabatrin	2015
Author Response. Neurology, 2015, Aug-18, Volume: 85, Issue:7 Topics: Anticonvulsants; Female; Humans; Male; Retinal Diseases; Spasms, Infantile; Vigabatrin	2015
Optical coherence tomography to monitor vigabatrin toxicity in children. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2016, Volume: 20, Issue:2 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroretinography; Female; Humans; Infant; M	2016
VIGABATRIN TOXICITY IN INFANCY IS ASSOCIATED WITH RETINAL DEFECT IN ADOLESCENCE: A Prospective Observational Study. Retina (Philadelphia, Pa.), 2017, Volume: 37, Issue:5 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Cross-Sectional Studies; Electroretinography	2017
Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:8 Topics: Anticonvulsants; Child; Child, Preschool; Contrast Sensitivity; Evoked Potentials, Visual; Female; H	2009
Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication. Effect of vigabatrin in the rabbit eye. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009, Volume: 247, Issue:8 Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroretinography; Enzyme Inhibitors;	2009
Electroretinogram changes in a pediatric population with epilepsy: is vigabatrin acting alone? Journal of child neurology, 2011, Volume: 26, Issue:6 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroretinography; Epilepsy; Female; Humans;	2011
Fundal changes in children receiving Vigabatrin. Indian journal of pediatrics, 2011, Volume: 78, Issue:10 Topics: Anticonvulsants; Child, Preschool; Follow-Up Studies; Humans; Infant; Ophthalmoscopy; Prospective St	2011
Screening for vigabatrin (Sabril ®) retinal toxicity in children. Ophthalmic genetics, 2011, Volume: 32, Issue:4 Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Child; Child, Preschool; Enzyme Inhibitors; Epileps	2011
Electroretinographic (ERG) responses in pediatric patients using vigabatrin. Documenta ophthalmologica. Advances in ophthalmology, 2012, Volume: 124, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroretinography; Humans; Infant; Mi	2012
Retinal function abnormalities in patients treated with vigabatrin. Archives of ophthalmology (Chicago, Ill. : 1960), 2003, Volume: 121, Issue:6 Topics: Adolescent; Adult; Anticonvulsants; Color Perception Tests; Dark Adaptation; Electroretinography; Ep	2003
Scotopic threshold response changes after vigabatrin therapy in a child without visual field defects: a new electroretinographic marker of early damage? Neurobiology of disease, 2004, Volume: 15, Issue:3 Topics: Adolescent; Anticonvulsants; Dark Adaptation; Electroretinography; Epilepsy; Humans; Male; Retinal D	2004
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. Epilepsia, 2004, Volume: 45, Issue:9 Topics: Acute Disease; Animals; Anticonvulsants; Darkness; gamma-Aminobutyric Acid; Light; Male; Nipecotic A	2004
[Efficacy and tolerability of vigabatrin in West syndrome]. Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:2B Topics: Anticonvulsants; Child; Child, Preschool; Female; GABA Agents; Humans; Infant; Male; Retinal Disease	2005
Vigabatrin retinopathy in an Irish cohort: lack of correlation with dose. Epilepsia, 2006, Volume: 47, Issue:2 Topics: Adult; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedu	2006
[Vigabatrin toxic retinopathy]. Archivos de la Sociedad Espanola de Oftalmologia, 2007, Volume: 82, Issue:11 Topics: Anticonvulsants; Electroretinography; Follow-Up Studies; Humans; Male; Middle Aged; Retinal Diseases	2007
Vigabatrin-associated retinal cone system dysfunction: electroretinogram and ophthalmologic findings. Neurology, 1998, Volume: 50, Issue:3 Topics: Adult; Aged; Anticonvulsants; Electroretinography; Evoked Potentials, Visual; Female; gamma-Aminobut	1998
Outer retinal dysfunction in patients treated with vigabatrin. Neurology, 1999, Apr-12, Volume: 52, Issue:6 Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Electrooculography; Electroretinography; Epilepsies	1999
Outer retinal dysfunction in patients treated with vigabatrin. Neurology, 2000, Mar-28, Volume: 54, Issue:6 Topics: Anticonvulsants; Epilepsies, Partial; Humans; Retinal Diseases; Vigabatrin	2000
Separating the retinal electrophysiologic effects of vigabatrin: treatment versus field loss. Neurology, 2000, Aug-08, Volume: 55, Issue:3 Topics: Adult; Anticonvulsants; Area Under Curve; Electrooculography; Electroretinography; Epilepsy; Female;	2000
Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction. Epilepsia, 2000, Volume: 41, Issue:11 Topics: Adult; Electrooculography; Electrophysiology; Electroretinography; Epilepsy; Evoked Potentials, Visu	2000
The wide field multifocal ERG reveals a retinal defect caused by vigabatrin toxicity. The British journal of ophthalmology, 2001, Volume: 85, Issue:1 Topics: Anticonvulsants; Electroretinography; Humans; Male; Middle Aged; Retinal Diseases; Vigabatrin	2001
Vigabatrin effect on inner retinal function. Ophthalmology, 2001, Volume: 108, Issue:8 Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Anticonvulsants; Electrooculography; Electroretinog	2001
Multifocal ERG and full-field ERG in patients on long-term vigabatrin medication. Documenta ophthalmologica. Advances in ophthalmology, 2001, Volume: 102, Issue:1 Topics: Adult; Aged; Anticonvulsants; Electroretinography; Humans; Middle Aged; Retinal Cone Photoreceptor C	2001
Vigabatrin associated retinal dysfunction in children with epilepsy. Archives of disease in childhood, 2001, Volume: 85, Issue:6 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Evoked Po	2001
Reversed visual field constrictions in children after vigabatrin withdrawal--true retinal recovery or improved test performance only? Seizure, 2001, Volume: 10, Issue:7 Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Recovery of Function; Retinal Diseases; Vigaba	2001

vigabatrin and Retinal Diseases

Research Excerpts

Research

Studies (39)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
McFarlane, MT	1
Wright, T	6
McCoy, B	2
Snead, OC	2
Westall, CA	6
Chan, K	1
Hoon, M	1
Pattnaik, BR	1
Ver Hoeve, JN	1
Wahlgren, B	1
Gloe, S	1
Williams, J	1
Wetherbee, B	1
Kiland, JA	1
Vogel, KR	1
Jansen, E	1
Salomons, G	1
Walters, D	1
Roullet, JB	1
Gibson, KM	1
McLellan, GJ	1
Ulate-Campos, A	1
Benavides-Lara, A	1
Hernández, L	1
Dragas, R	1
Westall, C	1
Cortese, F	1
Kumarappah, A	2
Buncic, JR	3
Akula, JD	1
Origlieri, C	1
Geddie, B	1
Karwoski, B	1
Berl, MM	1
Elling, N	1
McClintock, W	1
Alexander, J	1
Bazemore, M	1
de Beaufort, H	1
Hutcheson, K	1
Miller, M	1
Taylormoore, J	1
Jaafar, MS	1
Madigan, W	1
Stavropoulos, A	1
Reginald, A	1
Jaseja, H	1
Jammoul, F	1
Wang, Q	1
Nabbout, R	1
Coriat, C	1
Duboc, A	1
Simonutti, M	1
Dubus, E	1
Craft, CM	1
Ye, W	1
Collins, SD	1
Dulac, O	1
Chiron, C	1
Sahel, JA	1
Picaud, S	1
Durbin, S	1
Mirabella, G	1
Kjellström, U	1
Bruun, A	1
Ghosh, F	1
Andréasson, S	2
Ponjavic, V	2
Weiss, S	1
Go, C	1
Mishra, D	1
Kalra, V	1
Venkatesh, P	1
Seth, R	1
Gulati, S	1
Brodie, SE	1
Plant, GT	1
Sergott, RC	1
Pellock, JM	1
Moskowitz, A	1
Hansen, RM	1
Eklund, SE	1
Fulton, AB	1
Heim, MK	1
Gidal, BE	1
Banin, E	1
Shalev, RS	1
Obolensky, A	1
Neis, R	1
Chowers, I	1
Gross-Tsur, V	1
McDonagh, J	2
Stephen, LJ	1
Dolan, FM	1
Parks, S	2
Dutton, GN	1
Kelly, K	1
Keating, D	2
Sills, GJ	1
Brodie, MJ	1
Parisi, P	1
Tommasini, P	1
Piazza, G	1
Manfredi, M	1
Izumi, Y	1
Ishikawa, M	1
Benz, AM	1
Izumi, M	1
Zorumski, CF	1
Thio, LL	1
Moraes, MH	1
Montenegro, MA	1
Franzon, RC	1
Avila, JO	1
Guerreiro, MM	1
Kinirons, P	1
Cavalleri, GL	1
O'Rourke, D	1
Doherty, CP	1
Reid, I	1
Logan, P	1
Liggan, B	1
Delanty, N	1
Podboraczyńska-Jodkoi, K	1
Lubiński, W	1
Hampel-Osipowicz, E	1
Suárez-Baraza, J	1
Suárez-Parra, S	1
Krauss, GL	1
Johnson, MA	1
Miller, NR	1
Arndt, CF	1
Derambure, P	1
Defoort-Dhellemmes, S	1
Hache, JC	1
Hirsch, E	1
Harding, GF	2
Wild, JM	2
Robertson, KA	2
Rietbrock, S	1
Martinez, C	1
Hardus, P	1
Engelsman, M	1
van Veelen, CW	1
Stilma, JS	1
Lawden, MC	1
Betts, TA	1
Barber, C	1
Barnes, PM	1
Grierson, DJ	1
Coupland, SG	1
Zackon, DH	1
Leonard, BC	1
Ross, TM	1
Koul, R	1
Chacko, A	1
Ganesh, A	1
Bulusu, S	1
Al Riyami, K	1
Vanhatalo, S	1
Alen, R	1
Riikonen, R	1
Rantala, H	1
Aine, MR	1
Mustonen, K	1
Nousiainen, I	1