Page last updated: 2024-11-05

vigabatrin and Recrudescence

vigabatrin has been researched along with Recrudescence in 21 studies

Research Excerpts

ExcerptRelevanceReference
"To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence."8.12Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022)
" For each patient we recorded dates of infantile spasms onset, response to vigabatrin, relapse (if any), and quantified duration and dosage of vigabatrin after response."5.48High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. ( Bebin, EM; Goyal, M; Hussain, SA; Krueger, DA; Northrup, H; Peters, JM; Sahin, M; Schmid, E; Wu, JY, 2018)
"To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence."4.12Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022)
"Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy."3.69Vigabatrin monotherapy in resistant neonatal seizures. ( Barwick, DD; Baxter, PS; Gardner-Medwin, D; Ince, P; Livingston, J; Murdoch-Eaton, D, 1995)
"Vigabatrin (VGB) has been shown to be an effective drug in the treatment of infantile spasms (West syndrome) in predominantly retrospective and open but also in prospective studies."2.69Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. ( Appleton, RE; Mumford, JP; Peters, AC; Shaw, DE, 1999)
"ACTH should be the first choice for treatment of infantile spasms."2.42Infantile spasms: therapy and outcome. ( Riikonen, R, 2004)
"Vigabatrin (VGB) is a new antiepileptic drug useful in refractOry partial seizures."2.41[Acute encephalopathy and myoclonic status induced by vigabatrin monotherapy] . ( García Pastor, A; García-Zarza, E; Peraita Adrados, R, 2000)
"Some seizure types and epilepsy syndromes appear more prone than others to exacerbation by a given drug."2.38The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin. ( Chiron, C; Dulac, O; Lortie, A; Mumford, J, 1993)
"Relapse was relatively common among all subgroups."1.51Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. ( Alayari, A; Eliyan, Y; Heesch, J; Hussain, SA; Rajaraman, RR; Sankar, R, 2019)
" For each patient we recorded dates of infantile spasms onset, response to vigabatrin, relapse (if any), and quantified duration and dosage of vigabatrin after response."1.48High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. ( Bebin, EM; Goyal, M; Hussain, SA; Krueger, DA; Northrup, H; Peters, JM; Sahin, M; Schmid, E; Wu, JY, 2018)
"Time to relapse was not affected by treatment with ZNS or TPM."1.43Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit. ( Alayari, A; Anderson, K; Hussain, SA; Lay, J; Rajaraman, RR; Sankar, R, 2016)
" During conditioning, rats were assigned to one of four METH dosage groups: 1."1.35Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference. ( Aquilina, SD; Brodie, JD; Dalal, RM; DeMarco, A; Dewey, SL; Hammel, C; Kahanda, M; Kothari, SK; Liebling, CN; Mullapudi, U; Pai, J; Patel, V; Schiffer, WK, 2009)
"Infantile spasms are typical crisis found in the childhood being a serious pathology with an obscure prognosis."1.31[Infantile spasms: experience in 13 cases]. ( Fonseca, LF; Oliveira, AL, 2000)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (42.86)18.2507
2000's6 (28.57)29.6817
2010's4 (19.05)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Dzau, W1
Cheng, S1
Snell, P1
Fahey, M1
Scheffer, IE1
Harvey, AS1
Howell, KB1
Sampaio, LPB1
Henriques-Souza, AMM1
Silveira, MRMD1
Seguti, L1
Santos, MLSF1
Montenegro, MA1
Antoniuk, S1
Manreza, MLG1
Hussain, SA3
Schmid, E1
Peters, JM1
Goyal, M1
Bebin, EM1
Northrup, H1
Sahin, M1
Krueger, DA1
Wu, JY1
Eliyan, Y1
Heesch, J1
Alayari, A2
Rajaraman, RR2
Sankar, R2
Lay, J1
Anderson, K1
DeMarco, A1
Dalal, RM1
Pai, J1
Aquilina, SD1
Mullapudi, U1
Hammel, C1
Kothari, SK1
Kahanda, M1
Liebling, CN1
Patel, V1
Schiffer, WK1
Brodie, JD1
Dewey, SL1
Ibrahim, S1
Gulab, S1
Ishaque, S1
Saleem, T1
Riikonen, R1
Kröll-Seger, J1
Kaminska, A1
Moutard, ML1
de Saint-Martin, A1
Guët, A1
Dulac, O4
Chiron, C4
Ylinen, A1
Kälviäinen, R1
Riekkinen, PJ1
Baxter, PS1
Gardner-Medwin, D1
Barwick, DD1
Ince, P1
Livingston, J1
Murdoch-Eaton, D1
Stolarek, I1
Blacklaw, J1
Forrest, G1
Brodie, MJ1
Appleton, RE2
Montiel-Viesca, F1
Lortie, A2
Mumford, J2
Dumas, C1
Mumford, JP2
Paillard, C1
Vanhulle, C1
Devaux, AM1
Ensel, P1
Monroc-Morval, M1
Blanc, T1
Peters, AC1
Shaw, DE1
Trimble, MR1
Rüsch, N1
Betts, T1
Crawford, PM1
Fonseca, LF1
Oliveira, AL1
García Pastor, A1
García-Zarza, E1
Peraita Adrados, R1
Beaumont, D1
Palacios, L1
Pajot, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116]250 participants (Anticipated)Interventional2020-05-18Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for vigabatrin and Recrudescence

ArticleYear
Infantile spasms: therapy and outcome.
    Journal of child neurology, 2004, Volume: 19, Issue:6

    Topics: Adrenocorticotropic Hormone; Humans; Infant; Infant, Newborn; Prospective Studies; Randomized Contro

2004
The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin.
    Neurology, 1993, Volume: 43, Issue:11 Suppl 5

    Topics: Aminocaproates; Anticonvulsants; Humans; Infant; Recurrence; Seizures; Vigabatrin

1993
[Acute encephalopathy and myoclonic status induced by vigabatrin monotherapy] .
    Neurologia (Barcelona, Spain), 2000, Volume: 15, Issue:8

    Topics: Acute Disease; Aged; Anticonvulsants; Brain Diseases, Metabolic; Cerebral Infarction; Disease Suscep

2000

Trials

5 trials available for vigabatrin and Recrudescence

ArticleYear
Clinical profile and treatment of infantile spasms using vigabatrin and ACTH--a developing country perspective.
    BMC pediatrics, 2010, Jan-15, Volume: 10

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Developing Countr

2010
Long-term efficacy and cognitive effects of vigabatrin.
    Acta neurologica Scandinavica. Supplementum, 1995, Volume: 162

    Topics: Anticonvulsants; Carbamazepine; Cognition; Dose-Response Relationship, Drug; Drug Administration Sch

1995
Vigabatrin and lamotrigine in refractory epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1994, Volume: 57, Issue:8

    Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex

1994
Vigabatrin in infantile spasms--why add on?
    Lancet (London, England), 1993, Apr-10, Volume: 341, Issue:8850

    Topics: Aminocaproates; Anticonvulsants; Humans; Infant; Recurrence; Spasms, Infantile; Vigabatrin

1993
Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Electroencephalogr

1999

Other Studies

13 other studies available for vigabatrin and Recrudescence

ArticleYear
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms.
    Journal of paediatrics and child health, 2022, Volume: 58, Issue:12

    Topics: Anticonvulsants; Humans; Infant; Prednisolone; Recurrence; Retrospective Studies; Spasm; Spasms, Inf

2022
Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants.
    Arquivos de neuro-psiquiatria, 2023, Volume: 81, Issue:9

    Topics: Anticonvulsants; Brazil; Child; Consensus; Epilepsy; Humans; Infant; Prednisolone; Recurrence; Spasm

2023
High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex.
    Epilepsy research, 2018, Volume: 148

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Prospective Studies

2018
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
    Pediatric neurology, 2019, Volume: 99

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clinical Protocols; Cohort Studies; Disease Susceptibi

2019
Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit.
    Epilepsia, 2016, Volume: 57, Issue:8

    Topics: Cohort Studies; Electroencephalography; Female; Fructose; Humans; Infant; Isoxazoles; Male; Recurren

2016
Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:2

    Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Conditioning, Classical;

2009
Severe relapse of epilepsy after vigabatrin withdrawal: for how long should we treat symptomatic infantile spasms?
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Cerebral Cortex; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; H

2007
Vigabatrin monotherapy in resistant neonatal seizures.
    Seizure, 1995, Volume: 4, Issue:1

    Topics: Agenesis of Corpus Callosum; Anticonvulsants; Atrophy; Brain; Cerebral Cortex; Dose-Response Relatio

1995
Optimizing the indication of vigabatrin in children with refractory epilepsy.
    Journal of child neurology, 1997, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Contraindications; Drug

1997
[Recurrence of herpes simplex encephalitis].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:10

    Topics: Acyclovir; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Benzodi

1999
Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables.
    Seizure, 2000, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Dominance, Cerebral; Dose-Response Relationship, Drug; Epilepsy;

2000
[Infantile spasms: experience in 13 cases].
    Arquivos de neuro-psiquiatria, 2000, Volume: 58, Issue:2B

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; Humans; Infant; Male; Prognosis; Recurrence; S

2000
Therapeutic trial of vigabatrin in refractory infantile spasms.
    Journal of child neurology, 1991, Volume: Suppl 2

    Topics: Adolescent; Aminocaproates; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dr

1991