vigabatrin has been researched along with Recrudescence in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence." | 8.12 | Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022) |
| " For each patient we recorded dates of infantile spasms onset, response to vigabatrin, relapse (if any), and quantified duration and dosage of vigabatrin after response." | 5.48 | High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. ( Bebin, EM; Goyal, M; Hussain, SA; Krueger, DA; Northrup, H; Peters, JM; Sahin, M; Schmid, E; Wu, JY, 2018) |
| "To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence." | 4.12 | Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022) |
| "Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy." | 3.69 | Vigabatrin monotherapy in resistant neonatal seizures. ( Barwick, DD; Baxter, PS; Gardner-Medwin, D; Ince, P; Livingston, J; Murdoch-Eaton, D, 1995) |
| "Vigabatrin (VGB) has been shown to be an effective drug in the treatment of infantile spasms (West syndrome) in predominantly retrospective and open but also in prospective studies." | 2.69 | Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. ( Appleton, RE; Mumford, JP; Peters, AC; Shaw, DE, 1999) |
| "ACTH should be the first choice for treatment of infantile spasms." | 2.42 | Infantile spasms: therapy and outcome. ( Riikonen, R, 2004) |
| "Vigabatrin (VGB) is a new antiepileptic drug useful in refractOry partial seizures." | 2.41 | [Acute encephalopathy and myoclonic status induced by vigabatrin monotherapy] . ( García Pastor, A; García-Zarza, E; Peraita Adrados, R, 2000) |
| "Some seizure types and epilepsy syndromes appear more prone than others to exacerbation by a given drug." | 2.38 | The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin. ( Chiron, C; Dulac, O; Lortie, A; Mumford, J, 1993) |
| "Relapse was relatively common among all subgroups." | 1.51 | Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. ( Alayari, A; Eliyan, Y; Heesch, J; Hussain, SA; Rajaraman, RR; Sankar, R, 2019) |
| " For each patient we recorded dates of infantile spasms onset, response to vigabatrin, relapse (if any), and quantified duration and dosage of vigabatrin after response." | 1.48 | High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. ( Bebin, EM; Goyal, M; Hussain, SA; Krueger, DA; Northrup, H; Peters, JM; Sahin, M; Schmid, E; Wu, JY, 2018) |
| "Time to relapse was not affected by treatment with ZNS or TPM." | 1.43 | Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit. ( Alayari, A; Anderson, K; Hussain, SA; Lay, J; Rajaraman, RR; Sankar, R, 2016) |
| " During conditioning, rats were assigned to one of four METH dosage groups: 1." | 1.35 | Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference. ( Aquilina, SD; Brodie, JD; Dalal, RM; DeMarco, A; Dewey, SL; Hammel, C; Kahanda, M; Kothari, SK; Liebling, CN; Mullapudi, U; Pai, J; Patel, V; Schiffer, WK, 2009) |
| "Infantile spasms are typical crisis found in the childhood being a serious pathology with an obscure prognosis." | 1.31 | [Infantile spasms: experience in 13 cases]. ( Fonseca, LF; Oliveira, AL, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (42.86) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Dzau, W | 1 |
| Cheng, S | 1 |
| Snell, P | 1 |
| Fahey, M | 1 |
| Scheffer, IE | 1 |
| Harvey, AS | 1 |
| Howell, KB | 1 |
| Sampaio, LPB | 1 |
| Henriques-Souza, AMM | 1 |
| Silveira, MRMD | 1 |
| Seguti, L | 1 |
| Santos, MLSF | 1 |
| Montenegro, MA | 1 |
| Antoniuk, S | 1 |
| Manreza, MLG | 1 |
| Hussain, SA | 3 |
| Schmid, E | 1 |
| Peters, JM | 1 |
| Goyal, M | 1 |
| Bebin, EM | 1 |
| Northrup, H | 1 |
| Sahin, M | 1 |
| Krueger, DA | 1 |
| Wu, JY | 1 |
| Eliyan, Y | 1 |
| Heesch, J | 1 |
| Alayari, A | 2 |
| Rajaraman, RR | 2 |
| Sankar, R | 2 |
| Lay, J | 1 |
| Anderson, K | 1 |
| DeMarco, A | 1 |
| Dalal, RM | 1 |
| Pai, J | 1 |
| Aquilina, SD | 1 |
| Mullapudi, U | 1 |
| Hammel, C | 1 |
| Kothari, SK | 1 |
| Kahanda, M | 1 |
| Liebling, CN | 1 |
| Patel, V | 1 |
| Schiffer, WK | 1 |
| Brodie, JD | 1 |
| Dewey, SL | 1 |
| Ibrahim, S | 1 |
| Gulab, S | 1 |
| Ishaque, S | 1 |
| Saleem, T | 1 |
| Riikonen, R | 1 |
| Kröll-Seger, J | 1 |
| Kaminska, A | 1 |
| Moutard, ML | 1 |
| de Saint-Martin, A | 1 |
| Guët, A | 1 |
| Dulac, O | 4 |
| Chiron, C | 4 |
| Ylinen, A | 1 |
| Kälviäinen, R | 1 |
| Riekkinen, PJ | 1 |
| Baxter, PS | 1 |
| Gardner-Medwin, D | 1 |
| Barwick, DD | 1 |
| Ince, P | 1 |
| Livingston, J | 1 |
| Murdoch-Eaton, D | 1 |
| Stolarek, I | 1 |
| Blacklaw, J | 1 |
| Forrest, G | 1 |
| Brodie, MJ | 1 |
| Appleton, RE | 2 |
| Montiel-Viesca, F | 1 |
| Lortie, A | 2 |
| Mumford, J | 2 |
| Dumas, C | 1 |
| Mumford, JP | 2 |
| Paillard, C | 1 |
| Vanhulle, C | 1 |
| Devaux, AM | 1 |
| Ensel, P | 1 |
| Monroc-Morval, M | 1 |
| Blanc, T | 1 |
| Peters, AC | 1 |
| Shaw, DE | 1 |
| Trimble, MR | 1 |
| Rüsch, N | 1 |
| Betts, T | 1 |
| Crawford, PM | 1 |
| Fonseca, LF | 1 |
| Oliveira, AL | 1 |
| García Pastor, A | 1 |
| García-Zarza, E | 1 |
| Peraita Adrados, R | 1 |
| Beaumont, D | 1 |
| Palacios, L | 1 |
| Pajot, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for vigabatrin and Recrudescence
| Article | Year |
|---|---|
Infantile spasms: therapy and outcome.
Topics: Adrenocorticotropic Hormone; Humans; Infant; Infant, Newborn; Prospective Studies; Randomized Contro | 2004 |
The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin.
Topics: Aminocaproates; Anticonvulsants; Humans; Infant; Recurrence; Seizures; Vigabatrin | 1993 |
[Acute encephalopathy and myoclonic status induced by vigabatrin monotherapy] .
Topics: Acute Disease; Aged; Anticonvulsants; Brain Diseases, Metabolic; Cerebral Infarction; Disease Suscep | 2000 |
5 trials available for vigabatrin and Recrudescence
| Article | Year |
|---|---|
Clinical profile and treatment of infantile spasms using vigabatrin and ACTH--a developing country perspective.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Developing Countr | 2010 |
Long-term efficacy and cognitive effects of vigabatrin.
Topics: Anticonvulsants; Carbamazepine; Cognition; Dose-Response Relationship, Drug; Drug Administration Sch | 1995 |
Vigabatrin and lamotrigine in refractory epilepsy.
Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex | 1994 |
Vigabatrin in infantile spasms--why add on?
Topics: Aminocaproates; Anticonvulsants; Humans; Infant; Recurrence; Spasms, Infantile; Vigabatrin | 1993 |
Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Electroencephalogr | 1999 |
13 other studies available for vigabatrin and Recrudescence
| Article | Year |
|---|---|
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms.
Topics: Anticonvulsants; Humans; Infant; Prednisolone; Recurrence; Retrospective Studies; Spasm; Spasms, Inf | 2022 |
Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants.
Topics: Anticonvulsants; Brazil; Child; Consensus; Epilepsy; Humans; Infant; Prednisolone; Recurrence; Spasm | 2023 |
High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Prospective Studies | 2018 |
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clinical Protocols; Cohort Studies; Disease Susceptibi | 2019 |
Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit.
Topics: Cohort Studies; Electroencephalography; Female; Fructose; Humans; Infant; Isoxazoles; Male; Recurren | 2016 |
Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Conditioning, Classical; | 2009 |
Severe relapse of epilepsy after vigabatrin withdrawal: for how long should we treat symptomatic infantile spasms?
Topics: Cerebral Cortex; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; H | 2007 |
Vigabatrin monotherapy in resistant neonatal seizures.
Topics: Agenesis of Corpus Callosum; Anticonvulsants; Atrophy; Brain; Cerebral Cortex; Dose-Response Relatio | 1995 |
Optimizing the indication of vigabatrin in children with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Contraindications; Drug | 1997 |
[Recurrence of herpes simplex encephalitis].
Topics: Acyclovir; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Benzodi | 1999 |
Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables.
Topics: Adolescent; Adult; Anticonvulsants; Dominance, Cerebral; Dose-Response Relationship, Drug; Epilepsy; | 2000 |
[Infantile spasms: experience in 13 cases].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; Humans; Infant; Male; Prognosis; Recurrence; S | 2000 |
Therapeutic trial of vigabatrin in refractory infantile spasms.
Topics: Adolescent; Aminocaproates; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dr | 1991 |