vigabatrin has been researched along with Pregnancy in 30 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vigabatrin was specifically designed to enhance gamma-aminobutyric acid (GABA) function in the CNS." | 7.77 | Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control. ( Grant, SM; Heel, RC, 1991) |
| "Vigabatrin (VGB) has several therapeutic advantages over older antiepileptic drugs (AED), but there is a lack of information about its potential reproductive toxicologic effects." | 5.36 | Vigabatrin (VGB) administered during late gestation lowers maternal folate concentration and causes pregnancy loss, fetal growth restriction and skeletal hypoplasia in the mouse. ( Abdulrazzaq, YM; Bastaki, SM; Nurulain, M; Padmanabhan, R; Shafiullah, M, 2010) |
| " Prophylactic intervention with sirolimus and vigabatrin may reduce the incidence of epilepsy." | 4.12 | Prenatal diagnosis and intervention improve developmental outcomes and epilepsy prognosis in children with tuberous sclerosis complex. ( Ding, Y; Wang, J; Wang, X; Wang, Y; Yu, L; Zhou, S; Zhou, Y, 2022) |
| " The interaction between Mthfr deficiency and neonatal exposure to the GABA-potentiating drug vigabatrin (GVG) in mice alters anxiety, memory, and social behavior in a gender-dependent manner." | 3.81 | Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure. ( Blumkin, E; Golan, HM; Melamed, O; Zuckerman, C, 2015) |
| "To determine whether a new model of cryptogenic infantile spasms consisting of prenatal priming with betamethasone and postnatal trigger of spasms by N-methyl-D-aspartate (NMDA) responds to chronic adrenocorticotropic hormone (ACTH) treatment, and has electroencephalography (EEG) signature, efficacy of treatments, and behavioral impairments similar to those in human infantile spasms." | 3.77 | Validation of the rat model of cryptogenic infantile spasms. ( Chachua, T; Velíšek, L; Velíšková, J; Yum, MS, 2011) |
| "Vigabatrin was specifically designed to enhance gamma-aminobutyric acid (GABA) function in the CNS." | 3.77 | Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control. ( Grant, SM; Heel, RC, 1991) |
| " By contrast, offspring of rats exposed to carbamazepine (which at the dose used produced low plasma concentrations) or to generalized convulsive seizures showed no clear-cut evidence of dysplasias." | 3.74 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| "several parameters, concerning fertility were measured in 40 albino male rats of Sprague Dawley strain, they were divided into 4 groups, group one received vehicle (distilled water), group two received Vigabatrin in a dose of 200 mg/kg body weight, group three received Lamotrigine in a dose of 30 mg/kg body weight, and group four received Gabapentin 100 mg/kg body weight." | 3.72 | The effect of Vigabatrin, Lamotrigine and Gabapentin on the fertility, weights, sex hormones and biochemical profiles of male rats. ( Abdul-Zahra, E; Bataineh, H; Daoud, AS; Otoom, S, 2004) |
| " In the last decade, pregnancy registries have been activated by collaborative groups of physicians in Europe (EURAP), North America (NAREP), Australia and India (the latter two recently merged into EURAP), to enroll a large number of exposed women to be monitored prospectively with standardized methods, and by three pharmaceutical companies marketing lamotrigine, gabapentin and vigabatrin, as part of their post-marketing surveillance." | 3.71 | Pregnancy registries in epilepsy. ( Annegers, JF; Beghi, E, 2001) |
| "5 months of pregnancy then carbamazepine 400 mg LP x 2/day, raised to 600 mg LP x 2/day at the 25th week of gestation because of epileptic crisis." | 3.69 | [Carbamazepine and vigabatrin in epileptic pregnant woman and side effects in the newborn infant]. ( Aboulghit, H; Beust, M; Kayemba Kay'S, S; Mourtada, A; Voisin, M, 1997) |
| "However, West syndrome has not been previously well described as a consequence." | 1.62 | West Syndrome in Children With Congenital Zika Virus Infection. ( Bustamante Amador, J; García Boyano, M; García-Segovia, R; Miño-León, G, 2021) |
| "Vigabatrin (VGB) has several therapeutic advantages over older antiepileptic drugs (AED), but there is a lack of information about its potential reproductive toxicologic effects." | 1.36 | Vigabatrin (VGB) administered during late gestation lowers maternal folate concentration and causes pregnancy loss, fetal growth restriction and skeletal hypoplasia in the mouse. ( Abdulrazzaq, YM; Bastaki, SM; Nurulain, M; Padmanabhan, R; Shafiullah, M, 2010) |
| "Vigabatrin (VGB) is an important treatment option for infantile spasms." | 1.33 | Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero. ( Heinonen, S; Herrgård, E; Kälviäinen, R; Pääkkönen, A; Sorri, I; Viinikainen, K, 2005) |
| " In animal models chronic use of vigabatrin is associated with irreversible myelin vacuolation." | 1.33 | The effects of vigabatrin on rat liver antioxidant status. ( Cengiz, M; Cetinel, O; Ozaydin, A; Ozkiliç, A; Seven, M; Yüksel, A, 2005) |
| " The toxic effect of gamma-vinyl-GABA was mimicked by a 24-h treatment with GABA (100 microM) and the GABA(A) receptor agonist, muscimol (10 microM), but not the GABA(B) receptor agonist, baclofen (10 microM)." | 1.31 | GABA(A)-mediated toxicity of hippocampal neurons in vitro. ( Lukasiuk, K; Pitkänen, A, 2000) |
| "Vigabatrin levels were higher in the placenta than in the embryo at 3." | 1.31 | Placental transfer of vigabatrin (gamma-vinyl GABA) and its effect on concentration of amino acids in the embryo of TO mice. ( Abdulrazzaq, YM; Bastaki, SM; Bener, A; Ibrahim, A; Padmanabhan, R, 2001) |
| "Vigabatrin is a new antiepileptic medication consisting of a racemic mixture of 50% active S enantiomer and 50% inactive R enantiomer." | 1.30 | Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers. ( Mai, J; Mumford, JP; O'Mahoney, T; Olive, G; Rey, E; Tran, A, 1998) |
| "We report the appearance of multifocal myoclonus in two adult patients treated with vigabatrin as an add-on drug for complex partial seizures." | 1.29 | Vigabatrin and multifocal myoclonus in adults with partial seizures. ( Neufeld, MY; Vishnevska, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Ding, Y | 1 |
| Zhou, Y | 1 |
| Yu, L | 1 |
| Zhou, S | 1 |
| Wang, Y | 1 |
| Wang, J | 1 |
| Chern, CR | 1 |
| Chern, CJ | 1 |
| Velíšková, J | 2 |
| Velíšek, L | 2 |
| Bustamante Amador, J | 1 |
| García-Segovia, R | 1 |
| García Boyano, M | 1 |
| Miño-León, G | 1 |
| Zuckerman, C | 1 |
| Blumkin, E | 1 |
| Melamed, O | 1 |
| Golan, HM | 1 |
| Piplani, S | 1 |
| Saini, V | 1 |
| Niraj, RR | 1 |
| Pushp, A | 1 |
| Kumar, A | 1 |
| Lawthom, C | 1 |
| Smith, PE | 1 |
| Wild, JM | 1 |
| Cazorla, MR | 1 |
| Verdú, A | 1 |
| Montes, C | 1 |
| Ayuga, F | 1 |
| Padmanabhan, R | 3 |
| Abdulrazzaq, YM | 3 |
| Bastaki, SM | 3 |
| Nurulain, M | 1 |
| Shafiullah, M | 1 |
| Chachua, T | 1 |
| Yum, MS | 1 |
| Gosakan, R | 1 |
| von Knorring, N | 1 |
| Stewart, P | 1 |
| Wu, SP | 1 |
| Shyu, MK | 1 |
| Liou, HH | 1 |
| Gau, CS | 1 |
| Lin, CJ | 1 |
| Daoud, AS | 1 |
| Bataineh, H | 1 |
| Otoom, S | 1 |
| Abdul-Zahra, E | 1 |
| Sorri, I | 1 |
| Herrgård, E | 1 |
| Viinikainen, K | 1 |
| Pääkkönen, A | 1 |
| Heinonen, S | 1 |
| Kälviäinen, R | 1 |
| Lombardo, SA | 1 |
| Leanza, G | 1 |
| Meli, C | 1 |
| Lombardo, ME | 1 |
| Mazzone, L | 1 |
| Vincenti, I | 1 |
| Cioni, M | 1 |
| Cengiz, M | 1 |
| Yüksel, A | 1 |
| Ozaydin, A | 1 |
| Ozkiliç, A | 1 |
| Cetinel, O | 1 |
| Seven, M | 1 |
| Cheng, VY | 1 |
| Bonin, RP | 1 |
| Chiu, MW | 1 |
| Newell, JG | 1 |
| MacDonald, JF | 1 |
| Orser, BA | 1 |
| Manent, JB | 1 |
| Jorquera, I | 1 |
| Mazzucchelli, I | 1 |
| Depaulis, A | 1 |
| Perucca, E | 1 |
| Ben-Ari, Y | 1 |
| Represa, A | 1 |
| Shafiullah, MM | 1 |
| Neufeld, MY | 1 |
| Vishnevska, S | 1 |
| Appleton, RE | 1 |
| Kayemba Kay'S, S | 1 |
| Beust, M | 1 |
| Aboulghit, H | 1 |
| Voisin, M | 1 |
| Mourtada, A | 1 |
| Tran, A | 1 |
| O'Mahoney, T | 1 |
| Rey, E | 2 |
| Mai, J | 1 |
| Mumford, JP | 1 |
| Olive, G | 2 |
| Lukasiuk, K | 1 |
| Pitkänen, A | 1 |
| Fraser, CM | 1 |
| Sills, GJ | 1 |
| Butler, E | 1 |
| Thompson, GG | 1 |
| Lindsay, K | 1 |
| Duncan, R | 1 |
| Howatson, A | 1 |
| Brodie, MJ | 1 |
| Ibrahim, A | 1 |
| Bener, A | 1 |
| Beghi, E | 1 |
| Annegers, JF | 1 |
| Challier, JC | 1 |
| Bintein, T | 1 |
| Grant, SM | 1 |
| Heel, RC | 1 |
| Gram, L | 2 |
| Larsson, OM | 2 |
| Johnsen, A | 1 |
| Schousboe, A | 2 |
| Schousboe, I | 1 |
2 reviews available for vigabatrin and Pregnancy
| Article | Year |
|---|---|
The new antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Acetates; Adolescent; Adult; Amines; Anticonvulsants; Child; Child, Pre | 1996 |
Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control.
Topics: 4-Aminobutyrate Transaminase; Adult; Aged; Aminocaproates; Animals; Ataxia; Child; Dyskinesia, Drug- | 1991 |
1 trial available for vigabatrin and Pregnancy
| Article | Year |
|---|---|
Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control.
Topics: 4-Aminobutyrate Transaminase; Adult; Aged; Aminocaproates; Animals; Ataxia; Child; Dyskinesia, Drug- | 1991 |
28 other studies available for vigabatrin and Pregnancy
| Article | Year |
|---|---|
Prenatal diagnosis and intervention improve developmental outcomes and epilepsy prognosis in children with tuberous sclerosis complex.
Topics: Child; Epilepsy; Female; Humans; Male; Pregnancy; Prenatal Diagnosis; Prognosis; Prospective Studies | 2022 |
ACTON PROLONGATUM® suppresses spasms head to head with Acthar® Gel in the model of infantile spasms.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Animals, Newborn; Anticonvulsants; Diseas | 2020 |
West Syndrome in Children With Congenital Zika Virus Infection.
Topics: Anticonvulsants; Ecuador; Female; Humans; Infant; Male; Microcephaly; Phenotype; Pregnancy; Pregnanc | 2021 |
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.
Topics: Animals; Anticonvulsants; Anxiety; Cell Adhesion Molecules, Neuronal; Cerebral Cortex; Exploratory B | 2015 |
Homology modelling and molecular docking studies of human placental cadherin protein for its role in teratogenic effects of anti-epileptic drugs.
Topics: Acetamides; Amines; Animals; Anticonvulsants; Binding Sites; Cadherins; Calcium; Cations, Divalent; | 2016 |
In utero exposure to vigabatrin: no indication of visual field loss.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Epilepsies, Partial; Fe | 2009 |
Early infantile epileptic encephalopathy with unusual favourable outcome.
Topics: Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Pre | 2010 |
Vigabatrin (VGB) administered during late gestation lowers maternal folate concentration and causes pregnancy loss, fetal growth restriction and skeletal hypoplasia in the mouse.
Topics: Animals; Anticonvulsants; Bone and Bones; Dietary Supplements; Embryonic Development; Female; Fetal | 2010 |
Validation of the rat model of cryptogenic infantile spasms.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Betamethasone; Disease Models, Animal; Elect | 2011 |
Successful pregnancy in a patient with hyperoxaluria and combined liver and renal transplant.
Topics: Adult; Epilepsy; Female; Humans; Hyperoxaluria; Infant, Newborn; Kidney Transplantation; Liver Trans | 2003 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn | 2004 |
The effect of Vigabatrin, Lamotrigine and Gabapentin on the fertility, weights, sex hormones and biochemical profiles of male rats.
Topics: Amines; Analgesics; Animals; Antimanic Agents; Body Weight; Cyclohexanecarboxylic Acids; Female; Fer | 2004 |
Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Female; Functional Laterality; Humans; Male; Neurologic Exa | 2005 |
Maternal exposure to the antiepileptic drug vigabatrin affects postnatal development in the rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Birth Weight; Body Weight; Brain Chemi | 2005 |
The effects of vigabatrin on rat liver antioxidant status.
Topics: Animals; Anticonvulsants; Antioxidants; Female; Gestational Age; Glutathione; Glutathione Peroxidase | 2005 |
Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons.
Topics: 4-Aminobutyrate Transaminase; Amines; Analgesics; Animals; Blotting, Western; Cyclohexanecarboxylic | 2006 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus | 2007 |
Intrauterine growth restriction and skeletal variations in mouse fetuses induced by vigabatrin administered at preimplantation stages of development.
Topics: Animals; Anticonvulsants; Bone and Bones; Embryonic Development; Female; Fetal Growth Retardation; L | 2008 |
Vigabatrin and multifocal myoclonus in adults with partial seizures.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Complex Partial; Female; gamma-Aminobutyri | 1995 |
[Carbamazepine and vigabatrin in epileptic pregnant woman and side effects in the newborn infant].
Topics: Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Chlorine; Drug Therapy, Combination; Epilepsy; | 1997 |
Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers.
Topics: Adult; Anticonvulsants; Central Nervous System; Female; Fetal Blood; gamma-Aminobutyric Acid; Humans | 1998 |
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
Topics: Animals; Anticonvulsants; Bicuculline; Cell Survival; Cells, Cultured; Epilepsy; Female; Fetus; GABA | 2000 |
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Topics: Adult; Anticonvulsants; Astrocytes; Carrier Proteins; Cells, Cultured; Female; Fetus; GABA Plasma Me | 1999 |
Placental transfer of vigabatrin (gamma-vinyl GABA) and its effect on concentration of amino acids in the embryo of TO mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Animals; Embryo, Mammalian; Enzyme Inhibitors; Female; Ma | 2001 |
Pregnancy registries in epilepsy.
Topics: Abnormalities, Drug-Induced; Acetates; Amines; Anticonvulsants; Australia; Cross-Cultural Comparison | 2001 |
Passage of S(+) and R(-) gamma-vinyl-GABA across the human isolated perfused placenta.
Topics: Aminocaproates; Anticonvulsants; Antipyrine; Female; Humans; In Vitro Techniques; Leucine; Perfusion | 1992 |
Experimental studies of the influence of vigabatrin on the GABA system.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Astrocytes; Cells, Cultured; | 1989 |
Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Animals, Newborn; Astrocytes; Cells, Cultured | 1986 |