vigabatrin has been researched along with Intellectual Disability in 15 studies
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The short- and long-term clinical efficacy of add-on vigabatrin treatment was evaluated in a group of 36 patients with intellectual disability and drug-refractory epilepsy." | 9.08 | Antiepileptic efficacy of vigabatrin in people with severe epilepsy and intellectual disability. ( Ylinen, A, 1998) |
| " Vigabatrin has shown efficacy in the treatment of infantile spasms caused by tuberous sclerosis complex, but its effects on focal seizures caused by tuberous sclerosis complex have not been determined." | 7.79 | Vigabatrin and mental retardation in tuberous sclerosis: infantile spasms versus focal seizures. ( Ko, TS; Lee, EH; Yum, MS, 2013) |
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 7.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "The long-term clinical, neurophysiologic, and psychological effects of add-on vigabatrin treatment were evaluated in a group of 36 mentally handicapped patients with drug-refractory epilepsy." | 7.68 | Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study. ( Luukkainen, R; Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, PJ; Ruutiainen, T; Seppänen, R; Ylinen, A, 1993) |
| " The anticonvulsant potency of vigabatrin (gamma-vinyl GABA, GVG) was studied in an open trial in a group of 21 mentally handicapped patients with drug-resistant epilepsy." | 7.67 | Vigabatrin in epilepsy in mentally retarded patients. ( Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, P; Ruutiainen, T, 1989) |
| "We studied the antiepileptic potency of vigabatrin (gamma-vinyl GABA, GVG) as an open trial in a group of 36 mentally handicapped patients with drug-resistant epilepsy (30 had seizures of partial onset and 6 had primary generalized [PG] tonic-clonic convulsions)." | 7.67 | Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study. ( Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, P; Ruutiainen, T; Sarlund, H, 1988) |
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 5.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| "Ten patients with refractory partial epilepsy, previous mental retardation and psychosis or other significant psychiatric morbidity treated with vigabatrin were submitted periodically to specific tests (to quantify any possible change in behavioural parameters) and also to EEG recordings." | 5.09 | Vigabatrin use in psychotic epileptic patients: report of a prospective pilot study. ( Baldi, PL; De Agostini, G; Ferrari Ginevra, O; Lanzi, G; Muzio, C; Termine, C; Veggiotti, P, 1999) |
| "The short- and long-term clinical efficacy of add-on vigabatrin treatment was evaluated in a group of 36 patients with intellectual disability and drug-refractory epilepsy." | 5.08 | Antiepileptic efficacy of vigabatrin in people with severe epilepsy and intellectual disability. ( Ylinen, A, 1998) |
| " Vigabatrin has shown efficacy in the treatment of infantile spasms caused by tuberous sclerosis complex, but its effects on focal seizures caused by tuberous sclerosis complex have not been determined." | 3.79 | Vigabatrin and mental retardation in tuberous sclerosis: infantile spasms versus focal seizures. ( Ko, TS; Lee, EH; Yum, MS, 2013) |
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 3.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "The long-term clinical, neurophysiologic, and psychological effects of add-on vigabatrin treatment were evaluated in a group of 36 mentally handicapped patients with drug-refractory epilepsy." | 3.68 | Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study. ( Luukkainen, R; Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, PJ; Ruutiainen, T; Seppänen, R; Ylinen, A, 1993) |
| " The anticonvulsant potency of vigabatrin (gamma-vinyl GABA, GVG) was studied in an open trial in a group of 21 mentally handicapped patients with drug-resistant epilepsy." | 3.67 | Vigabatrin in epilepsy in mentally retarded patients. ( Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, P; Ruutiainen, T, 1989) |
| "We studied the antiepileptic potency of vigabatrin (gamma-vinyl GABA, GVG) as an open trial in a group of 36 mentally handicapped patients with drug-resistant epilepsy (30 had seizures of partial onset and 6 had primary generalized [PG] tonic-clonic convulsions)." | 3.67 | Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study. ( Matilainen, R; Mervaala, E; Pitkänen, A; Riekkinen, P; Ruutiainen, T; Sarlund, H, 1988) |
| "Epilepsy is common in individuals who are mentally retarded and/or otherwise multiply handicapped." | 2.39 | The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps. ( Mattson, RH, 1996) |
| "Introduccion." | 1.39 | [Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy]. ( Benavides-Lara, A; Hernández, L; Ulate-Campos, A, 2013) |
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 1.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kessi, M | 1 |
| Chen, B | 1 |
| Shan, LD | 1 |
| Wang, Y | 1 |
| Yang, L | 1 |
| Yin, F | 1 |
| He, F | 1 |
| Peng, J | 1 |
| Wang, G | 1 |
| Ulate-Campos, A | 1 |
| Benavides-Lara, A | 1 |
| Hernández, L | 1 |
| Balestrini, S | 1 |
| Clayton, LM | 1 |
| Bartmann, AP | 1 |
| Chinthapalli, K | 1 |
| Novy, J | 1 |
| Coppola, A | 1 |
| Wandschneider, B | 1 |
| Stern, WM | 1 |
| Acheson, J | 1 |
| Bell, GS | 1 |
| Sander, JW | 1 |
| Sisodiya, SM | 1 |
| Yum, MS | 1 |
| Lee, EH | 1 |
| Ko, TS | 1 |
| Leuzzi, V | 1 |
| Di Sabato, ML | 1 |
| Deodato, F | 1 |
| Rizzo, C | 1 |
| Boenzi, S | 1 |
| Carducci, C | 1 |
| Malaspina, P | 1 |
| Liberanome, C | 1 |
| Dionisi-Vici, C | 1 |
| Pitkänen, A | 3 |
| Ylinen, A | 2 |
| Matilainen, R | 3 |
| Luukkainen, R | 1 |
| Mervaala, E | 3 |
| Seppänen, R | 1 |
| Ruutiainen, T | 3 |
| Riekkinen, PJ | 1 |
| Mattson, RH | 1 |
| Gibson, KM | 1 |
| Christensen, E | 1 |
| Jakobs, C | 1 |
| Fowler, B | 1 |
| Clarke, MA | 1 |
| Hammersen, G | 1 |
| Raab, K | 1 |
| Kobori, J | 1 |
| Moosa, A | 1 |
| Vollmer, B | 1 |
| Rossier, E | 1 |
| Iafolla, AK | 1 |
| Matern, D | 1 |
| Brouwer, OF | 1 |
| Finkelstein, J | 1 |
| Aksu, F | 1 |
| Weber, HP | 1 |
| Bakkeren, JA | 1 |
| Gabreels, FJ | 1 |
| Bluestone, D | 1 |
| Barron, TF | 1 |
| Beauvais, P | 1 |
| Rabier, D | 1 |
| Santos, C | 1 |
| Lehnert, W | 1 |
| Bhaumik, S | 1 |
| Branford, D | 1 |
| Duggirala, C | 1 |
| Ismail, IA | 1 |
| Veggiotti, P | 1 |
| De Agostini, G | 1 |
| Muzio, C | 1 |
| Termine, C | 1 |
| Baldi, PL | 1 |
| Ferrari Ginevra, O | 1 |
| Lanzi, G | 1 |
| Roubergue, A | 1 |
| Schlumberger, ME | 1 |
| Billette de Villemeur, T | 1 |
| Jambaqué, I | 1 |
| Chiron, C | 1 |
| Dumas, C | 1 |
| Mumford, J | 1 |
| Dulac, O | 1 |
| Riekkinen, P | 2 |
| Sarlund, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for vigabatrin and Intellectual Disability
| Article | Year |
|---|---|
The role of the old and the new antiepileptic drugs in special populations: mental and multiple handicaps.
Topics: Acetates; Amines; Anticonvulsants; Cerebral Palsy; Cyclohexanecarboxylic Acids; Disabled Persons; Dr | 1996 |
2 trials available for vigabatrin and Intellectual Disability
| Article | Year |
|---|---|
Antiepileptic efficacy of vigabatrin in people with severe epilepsy and intellectual disability.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Follow-Up Studies; | 1998 |
Vigabatrin use in psychotic epileptic patients: report of a prospective pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Behavioral Symptoms; Child; Child, Preschool; Drug Administratio | 1999 |
12 other studies available for vigabatrin and Intellectual Disability
| Article | Year |
|---|---|
Genotype-phenotype correlations of STXBP1 pathogenic variants and the treatment choices for STXBP1-related disorders in China.
Topics: Adrenocorticotropic Hormone; China; Female; Genetic Association Studies; Humans; Intellectual Disabi | 2023 |
[Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy].
Topics: Anticonvulsants; Autistic Disorder; Brain Diseases; Brain Neoplasms; Child, Preschool; Comorbidity; | 2013 |
Retinal nerve fibre layer thinning is associated with drug resistance in epilepsy.
Topics: Adult; Anticonvulsants; Cohort Studies; Cross-Sectional Studies; Drug Resistant Epilepsy; Female; Hu | 2016 |
Vigabatrin and mental retardation in tuberous sclerosis: infantile spasms versus focal seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Intellectual Disa | 2013 |
Vigabatrin improves paroxysmal dystonia in succinic semialdehyde dehydrogenase deficiency.
Topics: Adolescent; Brain; Brain Diseases, Metabolic; Dystonic Disorders; Epilepsy; Extremities; GABA Agents | 2007 |
Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study.
Topics: Adult; Aminocaproates; Anticonvulsants; Drug Resistance; Electroencephalography; Epilepsy; Female; F | 1993 |
The clinical phenotype of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria): case reports of 23 new patients.
Topics: Adolescent; Adult; Aldehyde Oxidoreductases; Child; Child, Preschool; Developmental Disabilities; Di | 1997 |
A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Comorbidity; Cyclohexanecarboxylic Acids; Dose-Respo | 1997 |
[The usefulness of statistical tests in publications].
Topics: 4-Aminobutyrate Transaminase; Anti-Inflammatory Agents; Anticonvulsants; Chi-Square Distribution; En | 1999 |
Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients.
Topics: Anticonvulsants; Autistic Disorder; Child Behavior Disorders; Cognition Disorders; Drug Therapy, Com | 2000 |
Vigabatrin in epilepsy in mentally retarded patients.
Topics: Adult; Aminocaproates; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Intellectu | 1989 |
Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study.
Topics: Adolescent; Adult; Aminocaproates; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Huma | 1988 |