vigabatrin has been researched along with Huntington Disease in 3 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gale, K | 1 |
| Casu, M | 1 |
| Scigliano, G | 1 |
| Giovannini, P | 1 |
| Girotti, F | 1 |
| Grassi, MP | 1 |
| Caraceni, T | 1 |
| Schechter, PJ | 1 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
2 reviews available for vigabatrin and Huntington Disease
| Article | Year |
|---|---|
Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications.
Topics: 4-Aminobutyrate Transaminase; Afferent Pathways; Aminocaproates; Animals; Basal Ganglia; Behavior, A | 1981 |
Gamma-vinyl GABA.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Behavior, Animal; beta-Alanine; | 1985 |
1 trial available for vigabatrin and Huntington Disease
| Article | Year |
|---|---|
Gamma-vinyl GABA treatment of Huntington's disease.
Topics: Aminocaproates; Double-Blind Method; Female; Humans; Huntington Disease; Male; Middle Aged; Vigabatr | 1984 |