vigabatrin has been researched along with Friedreich Ataxia in 2 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Smet, Y | 1 |
| Mear, JY | 1 |
| Tell, G | 2 |
| Schechter, PH | 1 |
| Lhermitte, F | 1 |
| Agid, Y | 2 |
| Bonnet, AM | 1 |
| Esteguy, M | 1 |
| Schechter, PJ | 1 |
| Hardenberg, J | 1 |
1 trial available for vigabatrin and Friedreich Ataxia
| Article | Year |
|---|---|
A controlled study of oral vigabatrin (gamma-vinyl GABA) in patients with cerebellar ataxia.
Topics: Adolescent; Adult; Aminocaproates; Double-Blind Method; Drug Evaluation; Friedreich Ataxia; Humans; | 1986 |
1 other study available for vigabatrin and Friedreich Ataxia
| Article | Year |
|---|---|
Effect of gamma-vinyl GABA in Friedreich's ataxia.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Aminocaproates; Drug Tolerance; Female; Friedreich | 1982 |