vigabatrin has been researched along with Convulsive Generalized Seizure Disorder in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 7.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "To determine the efficacy of a new anti-epileptic medication vigabatrin in adults and children with drug-resistant epilepsy." | 7.69 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| "A retrospective survey was carried out of add-on treatment with lamotrigine (LTG) and vigabatrin (GVG) in 109 children with severe epilepsy, treated between 1987 and 1994, identified from a total population of 300 patients seen annually, in a tertiary referral outpatient clinic in Cardiff, Wales." | 7.69 | A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy. ( Gordon, GS; Schapel, GJ; Wallace, SJ, 1997) |
| "Twenty-five patients with epilepsy (mostly with partial seizures) who had responded favourably to a short-term trial of add-on vigabatrin entered maintenance treatment." | 7.68 | Six-year follow-up study on the efficacy and safety of vigabatrin in patients with epilepsy. ( Galimberti, CA; Iudice, A; Manni, R; Morini, R; Mumford, JP; Perucca, E; Tartara, A, 1992) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 6.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| "To date, 27 children with partial epilepsy, two with generalized epilepsy, two with Lennox-Gastaut syndrome, and one with nonclassifiable epilepsy have been enrolled in the trial." | 6.67 | Vigabatrin in pediatric epilepsy--an open study. ( Alving, J; Beck, S; Gram, L; Uldall, P, 1991) |
| "Twenty children aged 2 months to 18 years were included in a dose-response study of vigabatrin as add-on therapy to preexisting antiepileptic drugs (up to two per patient)." | 6.67 | Dose-response study of vigabatrin in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Beaumont, D; Farr, IN; Herranz, JL; Valdizan, E, 1991) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 5.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| "Vigabatrin was therefore an effective add-on therapy in 45% of these difficult-to-treat patients and allowed reduction of other AED treatment in a small number." | 5.28 | Vigabatrin in adults with poorly-controlled epilepsy and learning disabilities. ( Armour, DJ; Balarajan, S; Fidler, C; Wright, EC, 1992) |
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 3.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "To determine the efficacy of a new anti-epileptic medication vigabatrin in adults and children with drug-resistant epilepsy." | 3.69 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| "A retrospective survey was carried out of add-on treatment with lamotrigine (LTG) and vigabatrin (GVG) in 109 children with severe epilepsy, treated between 1987 and 1994, identified from a total population of 300 patients seen annually, in a tertiary referral outpatient clinic in Cardiff, Wales." | 3.69 | A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy. ( Gordon, GS; Schapel, GJ; Wallace, SJ, 1997) |
| "Twenty-five patients with epilepsy (mostly with partial seizures) who had responded favourably to a short-term trial of add-on vigabatrin entered maintenance treatment." | 3.68 | Six-year follow-up study on the efficacy and safety of vigabatrin in patients with epilepsy. ( Galimberti, CA; Iudice, A; Manni, R; Morini, R; Mumford, JP; Perucca, E; Tartara, A, 1992) |
| "Vigabatrin appears to be a reasonable choice for single-drug therapy in the treatment of certain types of seizures." | 2.68 | Newer antiepileptic drugs as monotherapy: data on vigabatrin. ( Fisher, R; Kälviäinen, R; Regesta, G; Tanganelli, P, 1996) |
| "Vigabatrin therapy was ineffective in the four children with tuberous sclerosis." | 2.68 | Vigabatrin in childhood epilepsy: comparable efficacy for generalized and partial seizures. ( Buckley, D; Hobbs, GR; Penney, S; Sheth, RD, 1996) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 2.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| " Vigabatrin mean dosage during phase 3 was 63." | 2.68 | Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study. ( Chisté, MA; da Costa, JC; Diament, A; Gherpelli, JL; Guerreiro, CA; Guerreiro, MM; Manreza, ML; Nunes, ML; Palmini, A; Pedroso, F; Reed, UC; Rotta, NT; Silva, EA; Vega-Gutiérrez, L; Vizioli, J, 1997) |
| "To date, 27 children with partial epilepsy, two with generalized epilepsy, two with Lennox-Gastaut syndrome, and one with nonclassifiable epilepsy have been enrolled in the trial." | 2.67 | Vigabatrin in pediatric epilepsy--an open study. ( Alving, J; Beck, S; Gram, L; Uldall, P, 1991) |
| "Twenty children aged 2 months to 18 years were included in a dose-response study of vigabatrin as add-on therapy to preexisting antiepileptic drugs (up to two per patient)." | 2.67 | Dose-response study of vigabatrin in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Beaumont, D; Farr, IN; Herranz, JL; Valdizan, E, 1991) |
| "Vigabatrin has been used as both add-on, and monotherapy in the treatment of spasms." | 2.39 | Vigabatrin in the management of generalized seizures in children. ( Appleton, RE, 1995) |
| "Lamotrigine is a useful add-on therapy in treating children with epilepsy." | 1.33 | The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood. ( Keegan, MB; Madden, D; McDonald, DG; McMenamin, JB; Najam, Y; Whooley, M, 2005) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 1.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| "Vigabatrin was therefore an effective add-on therapy in 45% of these difficult-to-treat patients and allowed reduction of other AED treatment in a small number." | 1.28 | Vigabatrin in adults with poorly-controlled epilepsy and learning disabilities. ( Armour, DJ; Balarajan, S; Fidler, C; Wright, EC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (77.78) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| von Hardenberg, S | 1 |
| Richter, MF | 1 |
| Hethey, S | 1 |
| Yaspo, ML | 1 |
| Auber, B | 1 |
| Schlegelberger, B | 1 |
| Illig, T | 1 |
| Guthmann, F | 1 |
| Christen, HJ | 1 |
| Ripperger, T | 1 |
| Bergmann, AK | 1 |
| Weckhuysen, S | 1 |
| Tajsharghi, H | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Mares, P | 1 |
| McDonald, DG | 1 |
| Najam, Y | 1 |
| Keegan, MB | 1 |
| Whooley, M | 1 |
| Madden, D | 1 |
| McMenamin, JB | 1 |
| Appleton, RE | 1 |
| Buchanan, N | 2 |
| Stolarek, I | 1 |
| Blacklaw, J | 1 |
| Forrest, G | 1 |
| Brodie, MJ | 1 |
| Walker, MC | 1 |
| Cockerell, OC | 1 |
| Sander, JW | 1 |
| Fisher, R | 1 |
| Kälviäinen, R | 1 |
| Tanganelli, P | 1 |
| Regesta, G | 1 |
| Sheth, RD | 1 |
| Buckley, D | 1 |
| Penney, S | 1 |
| Hobbs, GR | 1 |
| Bourgeois, B | 1 |
| Schapel, G | 1 |
| Chadwick, D | 1 |
| Panayiotopoulos, CP | 2 |
| Agathonikou, A | 1 |
| Sharoqi, IA | 1 |
| Parker, AP | 1 |
| Coppola, G | 1 |
| Terraciano, AM | 1 |
| Pascotto, A | 1 |
| Gherpelli, JL | 1 |
| Guerreiro, MM | 1 |
| da Costa, JC | 1 |
| Rotta, NT | 1 |
| Manreza, ML | 1 |
| Reed, UC | 1 |
| Diament, A | 1 |
| Silva, EA | 1 |
| Guerreiro, CA | 1 |
| Nunes, ML | 1 |
| Palmini, A | 1 |
| Vega-Gutiérrez, L | 1 |
| Vizioli, J | 1 |
| Pedroso, F | 1 |
| Chisté, MA | 1 |
| Schapel, GJ | 1 |
| Wallace, SJ | 1 |
| Gordon, GS | 1 |
| Berkovic, SF | 1 |
| Ifergane, G | 1 |
| Masalha, R | 1 |
| Zigulinski, R | 1 |
| Merkin, L | 1 |
| Wirguin, I | 1 |
| Herishanu, YO | 1 |
| Bélanger, S | 1 |
| Coulombe, G | 1 |
| Carmant, L | 1 |
| Jambaqué, I | 1 |
| Chiron, C | 1 |
| Dumas, C | 1 |
| Mumford, J | 1 |
| Dulac, O | 1 |
| Kmieć, T | 1 |
| Jóźwiak, S | 1 |
| Kuczyński, D | 1 |
| Karkowska, B | 1 |
| Bachański, M | 1 |
| Armour, DJ | 1 |
| Fidler, C | 1 |
| Wright, EC | 1 |
| Balarajan, S | 1 |
| Tartara, A | 1 |
| Manni, R | 1 |
| Galimberti, CA | 1 |
| Morini, R | 1 |
| Mumford, JP | 1 |
| Iudice, A | 1 |
| Perucca, E | 1 |
| Uldall, P | 1 |
| Alving, J | 1 |
| Gram, L | 1 |
| Beck, S | 1 |
| Herranz, JL | 1 |
| Arteaga, R | 1 |
| Farr, IN | 1 |
| Valdizan, E | 1 |
| Beaumont, D | 1 |
| Armijo, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for vigabatrin and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Vigabatrin in the management of generalized seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epileps | 1995 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
Aggravation of generalized epilepsies.
Topics: Acute Disease; Anticonvulsants; Carbamazepine; Epilepsy, Generalized; gamma-Aminobutyric Acid; Human | 1998 |
8 trials available for vigabatrin and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Vigabatrin and lamotrigine in refractory epilepsy.
Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex | 1994 |
Newer antiepileptic drugs as monotherapy: data on vigabatrin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies | 1996 |
Vigabatrin in childhood epilepsy: comparable efficacy for generalized and partial seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Enzyme Inhibitors; Epilepsies, Partial; Epilepsy, Genera | 1996 |
Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combinat | 1997 |
Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study.
Topics: Adolescent; Anticonvulsants; Brazil; Child; Child, Preschool; Epilepsies, Partial; Epilepsy, General | 1997 |
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi | 2000 |
Vigabatrin in pediatric epilepsy--an open study.
Topics: Adolescent; Aminocaproates; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dr | 1991 |
Dose-response study of vigabatrin in children with refractory epilepsy.
Topics: Adolescent; Aminocaproates; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dr | 1991 |
16 other studies available for vigabatrin and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Rational therapy with vigabatrin and a ketogenic diet in a patient with GAD1 deficiency.
Topics: Diet, Ketogenic; Epilepsy, Generalized; Humans; Infant, Newborn; Mental Disorders; Syndrome; Vigabat | 2020 |
Reply: Rational therapy with vigabatrin and a ketogenic diet in a patient with GAD1 deficiency.
Topics: Diet, Ketogenic; Epilepsy, Generalized; Humans; Infant, Newborn; Mental Disorders; Syndrome; Vigabat | 2020 |
Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?
Topics: Animals; Animals, Newborn; Anticonvulsants; Convulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clon | 2002 |
The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood.
Topics: Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Drug Therapy, Combina | 2005 |
Vigabatrin use in 72 patients with drug-resistant epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilep | 1994 |
Vigabatrin in drug-resistant epilepsy.
Topics: 4-Aminobutyrate Transaminase; Adult; Aminocaproates; Anticonvulsants; Child; Epilepsies, Partial; Ep | 1993 |
Vigabatrin and carbamazepine monotherapy for newly diagnosed epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies | 1996 |
A survey comparing lamotrigine and vigabatrin in everyday clinical practice.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epile | 1996 |
Vigabatrin aggravates absences and absence status.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; gamma-Amin | 1997 |
A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, P | 1997 |
Acute encephalopathy associated with vigabatrin monotherapy in patients with mild renal failure.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Electroencephalography; Encephalitis; Epilepsy, General | 1998 |
Role of vigabatrin and lamotrigine in treatment of childhood epileptic syndromes.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1998 |
Importance of specifying the type of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Contraindications; Diagnosis, Differential; Epilepsies, Parti | 1999 |
Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients.
Topics: Anticonvulsants; Autistic Disorder; Child Behavior Disorders; Cognition Disorders; Drug Therapy, Com | 2000 |
Vigabatrin in adults with poorly-controlled epilepsy and learning disabilities.
Topics: Adolescent; Adult; Aged; Aminocaproates; Anticonvulsants; Dose-Response Relationship, Drug; Drug The | 1992 |
Six-year follow-up study on the efficacy and safety of vigabatrin in patients with epilepsy.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Brain Stem; Cerebral Cortex; Electroencephalogra | 1992 |