vigabatrin has been researched along with Chemical Dependence in 6 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 5.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 1.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| " In the test of physical dependence-producing potential with the drug-admixed food method in rats, vigabatrin and diazepam were given to rats mixed with food for 28 days in an increasing dosage schedule, followed by feeding a drug-free diet to observe withdrawal signs for 7 days." | 1.30 | Drug dependence study on vigabatrin in rhesus monkeys and rats. ( Takada, K; Yanagita, T, 1997) |
| "Vigabatrin proved to be a potent anticonvulsant drug at acute doses (100-200 mg/kg), but during chronic administration, the anticonvulsant activity of the treatment was lost already in the second week of treatment." | 1.28 | Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats. ( Löscher, W; Rundfeldt, C, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silverman, RB | 1 |
| Brodie, JD | 1 |
| Figueroa, E | 1 |
| Laska, EM | 1 |
| Dewey, SL | 1 |
| Bhaumik, S | 1 |
| Branford, D | 1 |
| Duggirala, C | 1 |
| Ismail, IA | 1 |
| Takada, K | 1 |
| Yanagita, T | 1 |
| Knott, C | 1 |
| Panayiotopoulos, CP | 1 |
| Rundfeldt, C | 1 |
| Löscher, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind, Randomized, Placebo- Controlled Trial of Vigabatrin for Short Term Abstinence From Cocaine in Cocaine Dependent Parolees[NCT00527683] | Phase 2 | 100 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for vigabatrin and Chemical Dependence
| Article | Year |
|---|---|
Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction.
Topics: Cocaine-Related Disorders; Enzyme Inhibitors; Female; Humans; Male; Methamphetamine; Substance-Relat | 2005 |
5 other studies available for vigabatrin and Chemical Dependence
| Article | Year |
|---|---|
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Awards and Prizes; Cocaine-Related Disorders | 2012 |
A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Comorbidity; Cyclohexanecarboxylic Acids; Dose-Respo | 1997 |
Drug dependence study on vigabatrin in rhesus monkeys and rats.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Barbital; Conditioning, Operant; Female; gamma-Aminobu | 1997 |
Vigabatrin in the treatment of complex partial seizures.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, | 1992 |
Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Admini | 1992 |