vigabatrin has been researched along with Brain Edema in 7 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Affected versus unaffected patients, respectively, had a median age of 11 months versus 5 years, therapy duration 3 months versus 12 months, and dosage 170 mg/kg/day versus 87 mg/kg/day." | 1.35 | Cerebral MRI abnormalities associated with vigabatrin therapy. ( Conry, JA; de Menezes, MS; Elling, NJ; Ferri, R; Gaillard, WD; Gilles, E; Goodkin, HP; Heffron, A; Kadom, N; McCarter, R; McClintock, WM; Molloy-Wells, E; Pearl, PL; Saneto, RP; Trzcinski, S; Vezina, LG, 2009) |
| " In an attempt to image these changes in vivo, we performed high-field MRI on seven treated and four control dogs at baseline and after 15 weeks of dosing with vigabatrin (300 mg/kg/d)." | 1.29 | MRI monitoring of vigabatrin-induced intramyelinic edema in dogs. ( Arezzo, JC; Gibson, JP; Heydorn, WE; Kastin, SJ; McBride, RG; Schroeder, CE; Sussman, NM; Weiss, KL; Yarrington, JT, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearl, PL | 2 |
| Poduri, A | 1 |
| Prabhu, SP | 1 |
| Harini, C | 1 |
| Goldstein, R | 1 |
| Atkinson, RM | 1 |
| Armstrong, D | 1 |
| Kinney, H | 1 |
| Vezina, LG | 1 |
| Saneto, RP | 1 |
| McCarter, R | 1 |
| Molloy-Wells, E | 1 |
| Heffron, A | 1 |
| Trzcinski, S | 1 |
| McClintock, WM | 1 |
| Conry, JA | 1 |
| Elling, NJ | 1 |
| Goodkin, HP | 1 |
| de Menezes, MS | 1 |
| Ferri, R | 1 |
| Gilles, E | 1 |
| Kadom, N | 1 |
| Gaillard, WD | 1 |
| Cocito, L | 1 |
| Maffini, M | 1 |
| Weiss, KL | 1 |
| Schroeder, CE | 2 |
| Kastin, SJ | 1 |
| Gibson, JP | 3 |
| Yarrington, JT | 2 |
| Heydorn, WE | 3 |
| McBride, RG | 1 |
| Sussman, NM | 3 |
| Arezzo, JC | 2 |
| Peyster, RG | 1 |
| Hershey, BL | 1 |
| Meyerson, LR | 1 |
| Yarrington, J | 1 |
1 review available for vigabatrin and Brain Edema
| Article | Year |
|---|---|
Vigabatrin.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Brain Edema; Epilepsy; Human | 1989 |
6 other studies available for vigabatrin and Brain Edema
| Article | Year |
|---|---|
White matter spongiosis with vigabatrin therapy for infantile spasms.
Topics: Anticonvulsants; Brain Edema; Child, Preschool; Fatal Outcome; Humans; Infant, Newborn; Male; Spasms | 2018 |
Cerebral MRI abnormalities associated with vigabatrin therapy.
Topics: Adolescent; Anticonvulsants; Brain; Brain Edema; Child; Child, Preschool; Diffusion Magnetic Resonan | 2009 |
Vigabatrin edema.
Topics: Anticonvulsants; Brain; Brain Edema; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Vi | 1995 |
MRI monitoring of vigabatrin-induced intramyelinic edema in dogs.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain Edema; Dogs; gamma-Aminobutyric Acid; Hippocampus; Hypo | 1994 |
Use of ex vivo magnetic resonance imaging to detect onset of vigabatrin-induced intramyelinic edema in canine brain.
Topics: Animals; Anticonvulsants; Brain; Brain Edema; Dogs; Dose-Response Relationship, Drug; Female; gamma- | 1995 |
Effects of high-dose gamma-vinyl GABA (vigabatrin) administration on visual and somatosensory evoked potentials in dogs.
Topics: Aminocaproates; Animals; Anticonvulsants; Brain Edema; Dogs; Dose-Response Relationship, Drug; Drug | 1992 |