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vigabatrin and Benign Psychomotor Epilepsy, Childhood

vigabatrin has been researched along with Benign Psychomotor Epilepsy, Childhood in 24 studies

Research Excerpts

ExcerptRelevanceReference
"Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase."6.70Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001)
"The effect of introducing vigabatrin into the management of 57 patients with severe epilepsy is reported."3.68Vigabatrin: a three year clinical analysis. ( Martin, PJ; Millac, PA, 1993)
"Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase."2.70Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001)
" Thirty-seven patients discontinued vigabatrin for the following reasons: benefit-to-risk evaluation, 8; seizure breakthrough, 6; adverse events, 6; seizure breakthrough and adverse events, 5; moved or lost, 4; no longer eligible for study, 2; non-drug-related death, 2; narcotic abuse, 1; and patient request, three."2.67Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update. ( Ben-Menachem, E; Browne, TR; Mattson, RH; McBride, RG; Penry, JK; Sherry, KM; Smith, DB; Treiman, DM; Wilder, BJ, 1991)
" This may be related to dosage and speed of introduction."2.39Psychotic and severe behavioural reactions with vigabatrin: a review. ( Ferrie, CD; Panayiotopoulos, CP; Robinson, RO, 1996)
"Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy."1.29Treatment with antiepileptic drugs: possible neuroprotective effects. ( Pitkänen, A, 1996)
"A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug-resistant complex partial seizures."1.28Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans. ( Ben-Menachem, E, 1989)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19904 (16.67)18.7374
1990's9 (37.50)18.2507
2000's10 (41.67)29.6817
2010's1 (4.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Androsova, G1
Krause, R1
Borghei, M1
Wassenaar, M1
Auce, P1
Avbersek, A1
Becker, F1
Berghuis, B1
Campbell, E1
Coppola, A1
Francis, B1
Wolking, S1
Cavalleri, GL1
Craig, J1
Delanty, N1
Koeleman, BPC1
Kunz, WS1
Lerche, H1
Marson, AG1
Sander, JW1
Sills, GJ1
Striano, P1
Zara, F1
Sisodiya, SM1
Depondt, C1
André, V2
Dubé, C1
François, J1
Leroy, C1
Rigoulot, MA1
Roch, C1
Namer, IJ1
Nehlig, A2
Martin, PJ1
Millac, PA1
Pitkänen, A3
Ferrie, CD1
Robinson, RO1
Panayiotopoulos, CP2
Davie, MB1
Cook, MJ1
Ng, C1
Mecarelli, O1
De Feo, MR1
Del Priore, D1
Arroyo, S1
Rumiá, J1
Martínez, I1
Ribalta, T1
Hardus, P3
Verduin, WM3
Postma, G3
Stilma, JS3
Berendschot, TT3
van Veelen, CW3
García, A1
Gutiérrez, MA1
Barrasa, J1
Herranz, JL1
Lamusuo, S1
Jutila, L1
Ylinen, A2
Partanen, K1
Kälviäinen, R1
Ruottinen, HM1
Oikonen, V1
Någren, K1
Lehikoinen, P1
Vapalahti, M1
Vainio, P1
Rinne, JO1
Musshoff, U1
Köhling, R1
Lücke, A1
Speckmann, E1
Tuxhorn, I1
Wolf, P1
Pauuek, HW1
Oppel, F1
Theodore, WH1
Mueller, SG1
Weber, OM1
Duc, CO1
Weber, B1
Meier, D1
Russ, W1
Boesiger, P1
Wieser, HG2
Kamermans, M1
Ferrandon, A1
Marescaux, C1
Browne, TR2
Mattson, RH2
Penry, JK2
Smith, DB2
Treiman, DM2
Wilder, BJ2
Ben-Menachem, E3
McBride, RG1
Sherry, KM2
Agosti, R1
Yasargil, G1
Egli, M1
Wiestler, OD1
Riekkinen, PJ1
Halonen, T1
Lehtinen, M1
Sivenius, J1
Shin, C1
Rigsbee, LC1
McNamara, JO1
Napoliello, MJ1
Szabo, GK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism[NCT00001489]20 participants Observational1994-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for vigabatrin and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Psychotic and severe behavioural reactions with vigabatrin: a review.
    Acta neurologica Scandinavica, 1996, Volume: 93, Issue:1

    Topics: Adult; Anticonvulsants; Child; Contraindications; Dose-Response Relationship, Drug; Epilepsy; Epilep

1996
PET: cerebral blood flow and glucose metabolism--pathophysiology and drug effects.
    Advances in neurology, 2000, Volume: 83

    Topics: Anticonvulsants; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Glucose; Humans; Metabolic Cl

2000

Trials

4 trials available for vigabatrin and Benign Psychomotor Epilepsy, Childhood

ArticleYear
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
    Neurology, 2000, Jun-27, Volume: 54, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GA

2000
Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.
    Epilepsia, 2001, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Brain Chemistry; Carnosine; Creatine; Epilepsy; Epilepsy,

2001
Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update.
    Neurology, 1991, Volume: 41, Issue:3

    Topics: Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Humans; Longitudinal Studies; Vigabatrin

1991
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Adult; Aminocaproates; Anticonvulsants; Brain; Epilepsy, Temporal Lobe; Female

1988

Other Studies

18 other studies available for vigabatrin and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam;

2017
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
    Epilepsia, 2007, Volume: 48 Suppl 5

    Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco

2007
Vigabatrin: a three year clinical analysis.
    Seizure, 1993, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Dru

1993
Treatment with antiepileptic drugs: possible neuroprotective effects.
    Neurology, 1996, Volume: 47, Issue:1 Suppl 1

    Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Ner

1996
Vigabatrin overdose.
    The Medical journal of Australia, 1996, Oct-07, Volume: 165, Issue:7

    Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Overdose; Epilepsy, Temporal Lobe; Female; g

1996
Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.
    Pharmacological research, 1997, Volume: 36, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Enzyme Inhi

1997
[Drug-resistant epilepsy].
    Revista de neurologia, 1998, Volume: 27, Issue:159

    Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re

1998
Importance of specifying the type of epilepsy.
    Lancet (London, England), 1999, Dec-04, Volume: 354, Issue:9194

    Topics: Anticonvulsants; Carbamazepine; Child; Contraindications; Diagnosis, Differential; Epilepsies, Parti

1999
Concentric contraction of the visual field in patients with temporal lobe epilepsy and its association with the use of vigabatrin medication.
    Epilepsia, 2000, Volume: 41, Issue:5

    Topics: Anticonvulsants; Cross-Sectional Studies; Drug Resistance; Epilepsy, Temporal Lobe; Female; Humans;

2000
Long term changes in the visual fields of patients with temporal lobe epilepsy using vigabatrin.
    The British journal of ophthalmology, 2000, Volume: 84, Issue:7

    Topics: Anticonvulsants; Epilepsy, Temporal Lobe; Follow-Up Studies; Humans; Linear Models; Statistics, Nonp

2000
Cryptogenic gelastic epilepsy of frontal lobe origin: a paediatric case report.
    Seizure, 2000, Volume: 9, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsy, Fronta

2000
Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients.
    European journal of pharmacology, 2000, Aug-04, Volume: 401, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistanc

2000
The value of electrophysiology results in patients with epilepsy and vigabatrin associated visual field loss.
    Acta ophthalmologica Scandinavica, 2001, Volume: 79, Issue:2

    Topics: Adult; Anticonvulsants; Electrooculography; Electroretinography; Epilepsy, Temporal Lobe; Humans; Mi

2001
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
    Epilepsy research, 2001, Volume: 47, Issue:1-2

    Topics: Animals; Anticonvulsants; Antimanic Agents; Electroencephalography; Epilepsy, Temporal Lobe; Glutama

2001
Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles.
    Epilepsy research, 1990, Volume: 6, Issue:2

    Topics: Adult; Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Micros

1990
Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans.
    Epilepsia, 1989, Volume: 30 Suppl 3

    Topics: Adult; Amino Acids; Aminocaproates; Anticonvulsants; Cerebrospinal Fluid; Epilepsy, Temporal Lobe; F

1989
Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
    Brain research, 1986, Nov-29, Volume: 398, Issue:2

    Topics: Aminocaproates; Amygdala; Animals; Anticonvulsants; Electrophysiology; Epilepsy, Temporal Lobe; gamm

1986
Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up.
    Neurology, 1987, Volume: 37, Issue:2

    Topics: Aminocaproates; Anticonvulsants; Drug Interactions; Epilepsy, Temporal Lobe; Follow-Up Studies; Huma

1987