vigabatrin has been researched along with Benign Psychomotor Epilepsy, Childhood in 24 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 6.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| "The effect of introducing vigabatrin into the management of 57 patients with severe epilepsy is reported." | 3.68 | Vigabatrin: a three year clinical analysis. ( Martin, PJ; Millac, PA, 1993) |
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 2.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| " Thirty-seven patients discontinued vigabatrin for the following reasons: benefit-to-risk evaluation, 8; seizure breakthrough, 6; adverse events, 6; seizure breakthrough and adverse events, 5; moved or lost, 4; no longer eligible for study, 2; non-drug-related death, 2; narcotic abuse, 1; and patient request, three." | 2.67 | Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update. ( Ben-Menachem, E; Browne, TR; Mattson, RH; McBride, RG; Penry, JK; Sherry, KM; Smith, DB; Treiman, DM; Wilder, BJ, 1991) |
| " This may be related to dosage and speed of introduction." | 2.39 | Psychotic and severe behavioural reactions with vigabatrin: a review. ( Ferrie, CD; Panayiotopoulos, CP; Robinson, RO, 1996) |
| "Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy." | 1.29 | Treatment with antiepileptic drugs: possible neuroprotective effects. ( Pitkänen, A, 1996) |
| "A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug-resistant complex partial seizures." | 1.28 | Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans. ( Ben-Menachem, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Androsova, G | 1 |
| Krause, R | 1 |
| Borghei, M | 1 |
| Wassenaar, M | 1 |
| Auce, P | 1 |
| Avbersek, A | 1 |
| Becker, F | 1 |
| Berghuis, B | 1 |
| Campbell, E | 1 |
| Coppola, A | 1 |
| Francis, B | 1 |
| Wolking, S | 1 |
| Cavalleri, GL | 1 |
| Craig, J | 1 |
| Delanty, N | 1 |
| Koeleman, BPC | 1 |
| Kunz, WS | 1 |
| Lerche, H | 1 |
| Marson, AG | 1 |
| Sander, JW | 1 |
| Sills, GJ | 1 |
| Striano, P | 1 |
| Zara, F | 1 |
| Sisodiya, SM | 1 |
| Depondt, C | 1 |
| André, V | 2 |
| Dubé, C | 1 |
| François, J | 1 |
| Leroy, C | 1 |
| Rigoulot, MA | 1 |
| Roch, C | 1 |
| Namer, IJ | 1 |
| Nehlig, A | 2 |
| Martin, PJ | 1 |
| Millac, PA | 1 |
| Pitkänen, A | 3 |
| Ferrie, CD | 1 |
| Robinson, RO | 1 |
| Panayiotopoulos, CP | 2 |
| Davie, MB | 1 |
| Cook, MJ | 1 |
| Ng, C | 1 |
| Mecarelli, O | 1 |
| De Feo, MR | 1 |
| Del Priore, D | 1 |
| Arroyo, S | 1 |
| Rumiá, J | 1 |
| Martínez, I | 1 |
| Ribalta, T | 1 |
| Hardus, P | 3 |
| Verduin, WM | 3 |
| Postma, G | 3 |
| Stilma, JS | 3 |
| Berendschot, TT | 3 |
| van Veelen, CW | 3 |
| García, A | 1 |
| Gutiérrez, MA | 1 |
| Barrasa, J | 1 |
| Herranz, JL | 1 |
| Lamusuo, S | 1 |
| Jutila, L | 1 |
| Ylinen, A | 2 |
| Partanen, K | 1 |
| Kälviäinen, R | 1 |
| Ruottinen, HM | 1 |
| Oikonen, V | 1 |
| Någren, K | 1 |
| Lehikoinen, P | 1 |
| Vapalahti, M | 1 |
| Vainio, P | 1 |
| Rinne, JO | 1 |
| Musshoff, U | 1 |
| Köhling, R | 1 |
| Lücke, A | 1 |
| Speckmann, E | 1 |
| Tuxhorn, I | 1 |
| Wolf, P | 1 |
| Pauuek, HW | 1 |
| Oppel, F | 1 |
| Theodore, WH | 1 |
| Mueller, SG | 1 |
| Weber, OM | 1 |
| Duc, CO | 1 |
| Weber, B | 1 |
| Meier, D | 1 |
| Russ, W | 1 |
| Boesiger, P | 1 |
| Wieser, HG | 2 |
| Kamermans, M | 1 |
| Ferrandon, A | 1 |
| Marescaux, C | 1 |
| Browne, TR | 2 |
| Mattson, RH | 2 |
| Penry, JK | 2 |
| Smith, DB | 2 |
| Treiman, DM | 2 |
| Wilder, BJ | 2 |
| Ben-Menachem, E | 3 |
| McBride, RG | 1 |
| Sherry, KM | 2 |
| Agosti, R | 1 |
| Yasargil, G | 1 |
| Egli, M | 1 |
| Wiestler, OD | 1 |
| Riekkinen, PJ | 1 |
| Halonen, T | 1 |
| Lehtinen, M | 1 |
| Sivenius, J | 1 |
| Shin, C | 1 |
| Rigsbee, LC | 1 |
| McNamara, JO | 1 |
| Napoliello, MJ | 1 |
| Szabo, GK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism[NCT00001489] | 20 participants | Observational | 1994-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
Psychotic and severe behavioural reactions with vigabatrin: a review.
Topics: Adult; Anticonvulsants; Child; Contraindications; Dose-Response Relationship, Drug; Epilepsy; Epilep | 1996 |
PET: cerebral blood flow and glucose metabolism--pathophysiology and drug effects.
Topics: Anticonvulsants; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Glucose; Humans; Metabolic Cl | 2000 |
4 trials available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2000 |
Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Brain Chemistry; Carnosine; Creatine; Epilepsy; Epilepsy, | 2001 |
Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update.
Topics: Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Humans; Longitudinal Studies; Vigabatrin | 1991 |
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study.
Topics: Acetylcholinesterase; Adult; Aminocaproates; Anticonvulsants; Brain; Epilepsy, Temporal Lobe; Female | 1988 |
18 other studies available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
| Article | Year |
|---|---|
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; | 2017 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Vigabatrin: a three year clinical analysis.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Dru | 1993 |
Treatment with antiepileptic drugs: possible neuroprotective effects.
Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Ner | 1996 |
Vigabatrin overdose.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Overdose; Epilepsy, Temporal Lobe; Female; g | 1996 |
Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Enzyme Inhi | 1997 |
[Drug-resistant epilepsy].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re | 1998 |
Importance of specifying the type of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Contraindications; Diagnosis, Differential; Epilepsies, Parti | 1999 |
Concentric contraction of the visual field in patients with temporal lobe epilepsy and its association with the use of vigabatrin medication.
Topics: Anticonvulsants; Cross-Sectional Studies; Drug Resistance; Epilepsy, Temporal Lobe; Female; Humans; | 2000 |
Long term changes in the visual fields of patients with temporal lobe epilepsy using vigabatrin.
Topics: Anticonvulsants; Epilepsy, Temporal Lobe; Follow-Up Studies; Humans; Linear Models; Statistics, Nonp | 2000 |
Cryptogenic gelastic epilepsy of frontal lobe origin: a paediatric case report.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsy, Fronta | 2000 |
Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistanc | 2000 |
The value of electrophysiology results in patients with epilepsy and vigabatrin associated visual field loss.
Topics: Adult; Anticonvulsants; Electrooculography; Electroretinography; Epilepsy, Temporal Lobe; Humans; Mi | 2001 |
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Antimanic Agents; Electroencephalography; Epilepsy, Temporal Lobe; Glutama | 2001 |
Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles.
Topics: Adult; Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Micros | 1990 |
Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans.
Topics: Adult; Amino Acids; Aminocaproates; Anticonvulsants; Cerebrospinal Fluid; Epilepsy, Temporal Lobe; F | 1989 |
Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
Topics: Aminocaproates; Amygdala; Animals; Anticonvulsants; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 1986 |
Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up.
Topics: Aminocaproates; Anticonvulsants; Drug Interactions; Epilepsy, Temporal Lobe; Follow-Up Studies; Huma | 1987 |