vigabatrin has been researched along with Benign Psychomotor Epilepsy, Childhood in 24 studies
Excerpt | Relevance | Reference |
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"Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 6.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
"The effect of introducing vigabatrin into the management of 57 patients with severe epilepsy is reported." | 3.68 | Vigabatrin: a three year clinical analysis. ( Martin, PJ; Millac, PA, 1993) |
"Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 2.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
" Thirty-seven patients discontinued vigabatrin for the following reasons: benefit-to-risk evaluation, 8; seizure breakthrough, 6; adverse events, 6; seizure breakthrough and adverse events, 5; moved or lost, 4; no longer eligible for study, 2; non-drug-related death, 2; narcotic abuse, 1; and patient request, three." | 2.67 | Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update. ( Ben-Menachem, E; Browne, TR; Mattson, RH; McBride, RG; Penry, JK; Sherry, KM; Smith, DB; Treiman, DM; Wilder, BJ, 1991) |
" This may be related to dosage and speed of introduction." | 2.39 | Psychotic and severe behavioural reactions with vigabatrin: a review. ( Ferrie, CD; Panayiotopoulos, CP; Robinson, RO, 1996) |
"Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy." | 1.29 | Treatment with antiepileptic drugs: possible neuroprotective effects. ( Pitkänen, A, 1996) |
"A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug-resistant complex partial seizures." | 1.28 | Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans. ( Ben-Menachem, E, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (16.67) | 18.7374 |
1990's | 9 (37.50) | 18.2507 |
2000's | 10 (41.67) | 29.6817 |
2010's | 1 (4.17) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Androsova, G | 1 |
Krause, R | 1 |
Borghei, M | 1 |
Wassenaar, M | 1 |
Auce, P | 1 |
Avbersek, A | 1 |
Becker, F | 1 |
Berghuis, B | 1 |
Campbell, E | 1 |
Coppola, A | 1 |
Francis, B | 1 |
Wolking, S | 1 |
Cavalleri, GL | 1 |
Craig, J | 1 |
Delanty, N | 1 |
Koeleman, BPC | 1 |
Kunz, WS | 1 |
Lerche, H | 1 |
Marson, AG | 1 |
Sander, JW | 1 |
Sills, GJ | 1 |
Striano, P | 1 |
Zara, F | 1 |
Sisodiya, SM | 1 |
Depondt, C | 1 |
André, V | 2 |
Dubé, C | 1 |
François, J | 1 |
Leroy, C | 1 |
Rigoulot, MA | 1 |
Roch, C | 1 |
Namer, IJ | 1 |
Nehlig, A | 2 |
Martin, PJ | 1 |
Millac, PA | 1 |
Pitkänen, A | 3 |
Ferrie, CD | 1 |
Robinson, RO | 1 |
Panayiotopoulos, CP | 2 |
Davie, MB | 1 |
Cook, MJ | 1 |
Ng, C | 1 |
Mecarelli, O | 1 |
De Feo, MR | 1 |
Del Priore, D | 1 |
Arroyo, S | 1 |
Rumiá, J | 1 |
Martínez, I | 1 |
Ribalta, T | 1 |
Hardus, P | 3 |
Verduin, WM | 3 |
Postma, G | 3 |
Stilma, JS | 3 |
Berendschot, TT | 3 |
van Veelen, CW | 3 |
García, A | 1 |
Gutiérrez, MA | 1 |
Barrasa, J | 1 |
Herranz, JL | 1 |
Lamusuo, S | 1 |
Jutila, L | 1 |
Ylinen, A | 2 |
Partanen, K | 1 |
Kälviäinen, R | 1 |
Ruottinen, HM | 1 |
Oikonen, V | 1 |
Någren, K | 1 |
Lehikoinen, P | 1 |
Vapalahti, M | 1 |
Vainio, P | 1 |
Rinne, JO | 1 |
Musshoff, U | 1 |
Köhling, R | 1 |
Lücke, A | 1 |
Speckmann, E | 1 |
Tuxhorn, I | 1 |
Wolf, P | 1 |
Pauuek, HW | 1 |
Oppel, F | 1 |
Theodore, WH | 1 |
Mueller, SG | 1 |
Weber, OM | 1 |
Duc, CO | 1 |
Weber, B | 1 |
Meier, D | 1 |
Russ, W | 1 |
Boesiger, P | 1 |
Wieser, HG | 2 |
Kamermans, M | 1 |
Ferrandon, A | 1 |
Marescaux, C | 1 |
Browne, TR | 2 |
Mattson, RH | 2 |
Penry, JK | 2 |
Smith, DB | 2 |
Treiman, DM | 2 |
Wilder, BJ | 2 |
Ben-Menachem, E | 3 |
McBride, RG | 1 |
Sherry, KM | 2 |
Agosti, R | 1 |
Yasargil, G | 1 |
Egli, M | 1 |
Wiestler, OD | 1 |
Riekkinen, PJ | 1 |
Halonen, T | 1 |
Lehtinen, M | 1 |
Sivenius, J | 1 |
Shin, C | 1 |
Rigsbee, LC | 1 |
McNamara, JO | 1 |
Napoliello, MJ | 1 |
Szabo, GK | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism[NCT00001489] | 20 participants | Observational | 1994-10-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
Article | Year |
---|---|
Psychotic and severe behavioural reactions with vigabatrin: a review.
Topics: Adult; Anticonvulsants; Child; Contraindications; Dose-Response Relationship, Drug; Epilepsy; Epilep | 1996 |
PET: cerebral blood flow and glucose metabolism--pathophysiology and drug effects.
Topics: Anticonvulsants; Cerebrovascular Circulation; Epilepsy, Temporal Lobe; Glucose; Humans; Metabolic Cl | 2000 |
4 trials available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
Article | Year |
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[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Epilepsy, Temporal Lobe; Female; Flumazenil; GA | 2000 |
Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Brain Chemistry; Carnosine; Creatine; Epilepsy; Epilepsy, | 2001 |
Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update.
Topics: Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Humans; Longitudinal Studies; Vigabatrin | 1991 |
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study.
Topics: Acetylcholinesterase; Adult; Aminocaproates; Anticonvulsants; Brain; Epilepsy, Temporal Lobe; Female | 1988 |
18 other studies available for vigabatrin and Benign Psychomotor Epilepsy, Childhood
Article | Year |
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Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; | 2017 |
Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Autoradiography; Cell Count; Cerebral Cortex; Deoxygluco | 2007 |
Vigabatrin: a three year clinical analysis.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Dru | 1993 |
Treatment with antiepileptic drugs: possible neuroprotective effects.
Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Ner | 1996 |
Vigabatrin overdose.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Overdose; Epilepsy, Temporal Lobe; Female; g | 1996 |
Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Enzyme Inhi | 1997 |
[Drug-resistant epilepsy].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re | 1998 |
Importance of specifying the type of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Contraindications; Diagnosis, Differential; Epilepsies, Parti | 1999 |
Concentric contraction of the visual field in patients with temporal lobe epilepsy and its association with the use of vigabatrin medication.
Topics: Anticonvulsants; Cross-Sectional Studies; Drug Resistance; Epilepsy, Temporal Lobe; Female; Humans; | 2000 |
Long term changes in the visual fields of patients with temporal lobe epilepsy using vigabatrin.
Topics: Anticonvulsants; Epilepsy, Temporal Lobe; Follow-Up Studies; Humans; Linear Models; Statistics, Nonp | 2000 |
Cryptogenic gelastic epilepsy of frontal lobe origin: a paediatric case report.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsy, Fronta | 2000 |
Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistanc | 2000 |
The value of electrophysiology results in patients with epilepsy and vigabatrin associated visual field loss.
Topics: Adult; Anticonvulsants; Electrooculography; Electroretinography; Epilepsy, Temporal Lobe; Humans; Mi | 2001 |
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Antimanic Agents; Electroencephalography; Epilepsy, Temporal Lobe; Glutama | 2001 |
Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles.
Topics: Adult; Aminocaproates; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Micros | 1990 |
Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans.
Topics: Adult; Amino Acids; Aminocaproates; Anticonvulsants; Cerebrospinal Fluid; Epilepsy, Temporal Lobe; F | 1989 |
Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
Topics: Aminocaproates; Amygdala; Animals; Anticonvulsants; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 1986 |
Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up.
Topics: Aminocaproates; Anticonvulsants; Drug Interactions; Epilepsy, Temporal Lobe; Follow-Up Studies; Huma | 1987 |