vigabatrin has been researched along with Autistic Disorder in 5 studies
Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 7.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "The objective of this study was to compare the efficacy of corticotropin (ACTH) versus vigabatrin in treating infantile spasms and to determine which medication has a more favorable long-term outcome in terms of cognitive function, evolution of epilepsy, and incidence of autism." | 5.10 | Prospective preliminary analysis of the development of autism and epilepsy in children with infantile spasms. ( Askalan, R; Boyd, J; Brian, J; Bryson, S; Mackay, M; McDermott, C; Otsubo, H; Roberts, W; Snead, C; Weiss, S, 2003) |
| " The child was treated with vigabatrin at age 6 months after an abnormal electroencephalogram but before onset of seizures." | 3.73 | Autistic regression associated with seizure onset in an infant with tuberous sclerosis. ( Bolton, PF; Clarke, A; Humphrey, A; Neville, BG, 2006) |
| "Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis." | 3.70 | Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 2000) |
| "Introduccion." | 1.39 | [Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy]. ( Benavides-Lara, A; Hernández, L; Ulate-Campos, A, 2013) |
| "Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment." | 1.36 | A model of symptomatic infantile spasms syndrome. ( Betancourth, D; Chudomelova, L; Galanopoulou, AS; Moshé, SL; Raffo, E; Scantlebury, MH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ulate-Campos, A | 1 |
| Benavides-Lara, A | 1 |
| Hernández, L | 1 |
| Scantlebury, MH | 1 |
| Galanopoulou, AS | 1 |
| Chudomelova, L | 1 |
| Raffo, E | 1 |
| Betancourth, D | 1 |
| Moshé, SL | 1 |
| Askalan, R | 1 |
| Mackay, M | 1 |
| Brian, J | 1 |
| Otsubo, H | 1 |
| McDermott, C | 1 |
| Bryson, S | 1 |
| Boyd, J | 1 |
| Snead, C | 1 |
| Roberts, W | 1 |
| Weiss, S | 1 |
| Humphrey, A | 1 |
| Neville, BG | 1 |
| Clarke, A | 1 |
| Bolton, PF | 1 |
| Jambaqué, I | 1 |
| Chiron, C | 1 |
| Dumas, C | 1 |
| Mumford, J | 1 |
| Dulac, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for vigabatrin and Autistic Disorder
| Article | Year |
|---|---|
Prospective preliminary analysis of the development of autism and epilepsy in children with infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Autistic Disorder; Cognition Disorders; Electroencepha | 2003 |
4 other studies available for vigabatrin and Autistic Disorder
| Article | Year |
|---|---|
[Characterisation of the paediatric population of Costa Rica with tuberous sclerosis and a description of the behaviour of the associated epilepsy].
Topics: Anticonvulsants; Autistic Disorder; Brain Diseases; Brain Neoplasms; Child, Preschool; Comorbidity; | 2013 |
A model of symptomatic infantile spasms syndrome.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Anticonvulsants | 2010 |
Autistic regression associated with seizure onset in an infant with tuberous sclerosis.
Topics: Anticonvulsants; Autistic Disorder; Developmental Disabilities; Epilepsy; Humans; Infant; Male; Regr | 2006 |
Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients.
Topics: Anticonvulsants; Autistic Disorder; Child Behavior Disorders; Cognition Disorders; Drug Therapy, Com | 2000 |