vicenin-ii has been researched along with Diabetes-Mellitus* in 1 studies
1 other study(ies) available for vicenin-ii and Diabetes-Mellitus
| Article | Year |
|---|---|
Phenolic Substances from Ocimum Species Enhance Glucose-Stimulated Insulin Secretion and Modulate the Expression of Key Insulin Regulatory Genes in Mice Pancreatic Islets.
Ocimum gratissimum and Ocimum basilicum are plants ethnopharmacologically used to treat diabetes mellitus, a life-threatening disease that affects millions of people worldwide. In order to further understand their antidiabetic potential, which has been previously demonstrated in animal models, we aimed to investigate the acute and chronic effects of major phenolic substances from both plants on insulin secretion and gene expression in pancreatic islets isolated from NMRI mice. Insulin secretion was measured after acute (1 h) and long-term (72 h) incubation of islets with one of four cinnamic acid derivatives (caftaric, caffeic, chicoric, and rosmarinic acids) or a C-glucosylated flavonoid (vicenin-2). All substances acutely enhanced glucose-stimulated insulin secretion (GSIS) from islets at concentrations from 10 Topics: Animals; Biological Transport; Cinnamates; Diabetes Mellitus; Female; Flavonoids; Gene Expression; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Ocimum basilicum; Plant Extracts | 2017 |