vesnarinone has been researched along with Arrhythmias, Cardiac in 8 studies
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vesnarinone is associated with a dose-dependent increase in mortality among patients with severe heart failure, an increase that is probably related to an increase in deaths due to arrhythmia." | 9.08 | A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. ( Bourge, RC; Cohn, JN; DeMets, DL; Goldstein, SO; Gottlieb, SO; Greenberg, BH; Jaski, BE; Lorell, BH; McGrew, F; White, BG, 1998) |
| "Vesnarinone is associated with a dose-dependent increase in mortality among patients with severe heart failure, an increase that is probably related to an increase in deaths due to arrhythmia." | 5.08 | A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. ( Bourge, RC; Cohn, JN; DeMets, DL; Goldstein, SO; Gottlieb, SO; Greenberg, BH; Jaski, BE; Lorell, BH; McGrew, F; White, BG, 1998) |
| "Influence of 4,5-dihydro-6-[1-[2-hydroxy-2-(4-cyanophenyl)ethyl]- 1,2,5,6,-tetrahydropyrido-4-yl]pyridazin-3(2H)-one (SCH00013) and vesnarinone (CAS 81840-15-5) on the arrhythmia experimentally induced by three different methods was investigated in dogs." | 3.70 | Investigation on SCH00013, a novel cardiotonic agent with Ca++ sensitizing action. 4th communication: influence on experimentally induced ventricular arrhythmia in dogs. ( Endoh, M; Hino, M; Sakato, M; Sugawara, H; Yoshimura, A; Yoshioka, K, 1999) |
| "Xamoterol was highly effective in patients with atrial fibrillation who not only had excessive tachycardia during exercise but marked bradycardia at night." | 1.28 | [How to select newly-developed oral inotropic agents: an evaluation based on their effects on heart rate and arrhythmias]. ( Fukuda, K; Handa, S; Kawamura, Y; Nakamura, Y; Ogawa, S, 1990) |
| "With adrenaline-induced arrhythmias, the three drugs aggravated ventricular tachycardia to produce ventricular fibrillation." | 1.27 | Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias. ( Hashimoto, K; Mitsuhashi, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Kayık, G | 1 |
| Tüzün, NŞ | 1 |
| Durdagi, S | 1 |
| Cohn, JN | 1 |
| Goldstein, SO | 1 |
| Greenberg, BH | 1 |
| Lorell, BH | 1 |
| Bourge, RC | 1 |
| Jaski, BE | 1 |
| Gottlieb, SO | 1 |
| McGrew, F | 1 |
| DeMets, DL | 1 |
| White, BG | 1 |
| Yoshimura, A | 1 |
| Yoshioka, K | 1 |
| Hino, M | 1 |
| Sugawara, H | 1 |
| Sakato, M | 1 |
| Endoh, M | 1 |
| Feldman, AM | 1 |
| Baughman, KL | 1 |
| Lee, WK | 1 |
| Gottlieb, SH | 1 |
| Weiss, JL | 1 |
| Becker, LC | 1 |
| Strobeck, JE | 1 |
| Fukuda, K | 2 |
| Handa, S | 2 |
| Ogawa, S | 2 |
| Nakamura, Y | 2 |
| Kawamura, Y | 2 |
| Hashimoto, K | 1 |
| Mitsuhashi, H | 1 |
2 trials available for vesnarinone and Arrhythmias, Cardiac
| Article | Year |
|---|---|
A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators.
Topics: Aged; Agranulocytosis; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias, Cardiac; Cardiotonic A | 1998 |
Usefulness of OPC-8212, a quinolinone derivative, for chronic congestive heart failure in patients with ischemic heart disease or idiopathic dilated cardiomyopathy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Cardioton | 1991 |
6 other studies available for vesnarinone and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Structural investigation of vesnarinone at the pore domains of open and open-inactivated states of hERG1 K
Topics: Arrhythmias, Cardiac; ERG1 Potassium Channel; Humans; Molecular Docking Simulation; Molecular Dynami | 2017 |
Investigation on SCH00013, a novel cardiotonic agent with Ca++ sensitizing action. 4th communication: influence on experimentally induced ventricular arrhythmia in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agonists; Cardiotonic Agents; | 1999 |
[How to select newly-developed oral inotropic agents: an evaluation based on their effects on heart rate and arrhythmias].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Atrial Fibrillation; Car | 1990 |
[Usefulness of OPC-8212, an inotropic agent, in patients with chronic congestive heart failure--a multiple dose evaluation on its effect and arrhythmogenesis].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiotonic Agents; Drug | 1988 |
Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Dogs; Epinephrine; Female; Heart Ventricles; Ma | 1986 |