veronicastroside and Acute-Lung-Injury

Acute lung injury (ALI) is a life-threatening condition caused by severe inflammation of lung tissues. We hypothesized that lipopolysaccharide induced acute lung inflammation and injury in mice might be controlled by lonicerin (LCR), a plant flavonoid that impacts immunity, oxidative stress, and cell proliferation. LCR reduced pathological changes including pulmonary edema, elevation of protein in bronchoalveolar lavage, inflammation, pro-inflammatory gene expression, expression of toll-like receptor 4/nuclear factor-kappa B, apoptosis, and significantly reduced mortality. Together, the results suggest that LCR might be a potential and effective candidate for the treatment of ALI that acts by inhibiting inflammation and apoptosis.

Topics: Acute Lung Injury; Animals; Apoptosis; Cytokines; Gene Expression; Humans; Inflammation; Lipopolysaccharides; Lung; Luteolin; Male; Mice, Inbred C57BL; NF-kappa B; Survival Rate; Toll-Like Receptor 4