vermiculine and Leukemia-P388

vermiculine has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for vermiculine and Leukemia-P388

Article	Year
Vermiculin derivatives. Part 1: Synthesis of vermiculin derivatives. Die Pharmazie, 1993, Volume: 48, Issue:10 Hydrogenation of the macrodiolide antibiotic vermiculin (1) over Adams catalyst afforded [8S, 16S]-8,16-bis(2'-oxopropyl)-1,9- dioxyacyclohexadeca-2,5,10,13-tetrone (2), [8S, 16S]-8,16-bis(2'-oxopropyl)-13-hydroxy-1,9-dioxacyclohexadeca- 2,5,10-trione (3), [8S,16S]-8,16-bis(2' oxopropyl)-1,9- dioxacyclohexadeca-2,5,10-trione (4) together with [7S]-4,9-dioxo-7-(4',9'-dioxodecanoyloxy)decanoic acid (5). Hydrogenation of diolide 1 over Pd/C gave tetrahydrovermiculin (2) only. The prepared compounds showed lower antibacterial and cytotoxic activities than vermiculin (1). Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Arthrobacter; Bacteria; Hydrogenation; Lactones; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Tumor Cells, Cultured	1993

Article

Year

Vermiculin derivatives. Part 1: Synthesis of vermiculin derivatives.

Die Pharmazie, 1993, Volume: 48, Issue:10

Hydrogenation of the macrodiolide antibiotic vermiculin (1) over Adams catalyst afforded [8S, 16S]-8,16-bis(2'-oxopropyl)-1,9- dioxyacyclohexadeca-2,5,10,13-tetrone (2), [8S, 16S]-8,16-bis(2'-oxopropyl)-13-hydroxy-1,9-dioxacyclohexadeca- 2,5,10-trione (3), [8S,16S]-8,16-bis(2' oxopropyl)-1,9- dioxacyclohexadeca-2,5,10-trione (4) together with [7S]-4,9-dioxo-7-(4',9'-dioxodecanoyloxy)decanoic acid (5). Hydrogenation of diolide 1 over Pd/C gave tetrahydrovermiculin (2) only. The prepared compounds showed lower antibacterial and cytotoxic activities than vermiculin (1).

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Arthrobacter; Bacteria; Hydrogenation; Lactones; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Tumor Cells, Cultured

1993