verlukast has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for verlukast and Adenocarcinoma
Article | Year |
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Regulation of [Ca(2+)](i) homeostasis in MRP1 overexpressing cells.
Regulation of capacitative Ca(2+) entry was studied in two different multidrug resistance (MDR) protein (MRP1) overexpressing cell lines, HT29(col) and GLC4/ADR. MRP1 overexpression was accompanied by a decreased response to thapsigargin. Moreover, inhibition of capacitative Ca(2+) entry by D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) was abolished in MRP1 overexpressing cells. Both PDMP and the MRP1 inhibitor MK571 greatly reduced InsP(3)-mediated (45)Ca(2+) release from intracellular stores in HT29 cells. Again, these effects were virtually abolished in HT29(col) cells. Our results point to a modulatory role of MRP1 on intracellular calcium concentration ([Ca(2+)](i)) homeostasis which may contribute to the MDR phenotype. Topics: Adenocarcinoma; ATP-Binding Cassette Transporters; Calcium; Calcium Radioisotopes; Colonic Neoplasms; Gene Expression; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate; Morpholines; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Thapsigargin; Tumor Cells, Cultured | 2000 |