verapamil has been researched along with Substance Withdrawal Syndrome in 35 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The potential hazards of abrupt withdrawal of propranolol have been described in patients with angina pectoris; however, the effects of abrupt withdrawal from long-term therapy with verapamil have not previously been investigated." | 9.05 | Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris. ( Cohen, MN; Frishman, WH; Iorio, L; Klein, N; Klein, P; LeJemtel, T; Pollack, S; Roth, S; Shamoon, H; Sonnenblick, EH; Strom, J; Willens, H, 1982) |
| "Rats, chronically treated with diazepam (4 mg/kg/day) for 28 days, displayed increased anxiety when tested in the elevated plus-maze, 42 hr after the last dose." | 7.68 | Concurrent treatment with verapamil prevents diazepam withdrawal-induced anxiety, in the absence of altered calcium flux in cortical synaptosomes. ( File, SE; Hitchcott, PK; Zharkovsky, A, 1992) |
| "Verapamil is an effective and relatively-safe antihypertensive drug." | 5.27 | Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram. ( Beilin, LJ; Dimmitt, SB; Hockings, BE, 1988) |
| "The potential hazards of abrupt withdrawal of propranolol have been described in patients with angina pectoris; however, the effects of abrupt withdrawal from long-term therapy with verapamil have not previously been investigated." | 5.05 | Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris. ( Cohen, MN; Frishman, WH; Iorio, L; Klein, N; Klein, P; LeJemtel, T; Pollack, S; Roth, S; Shamoon, H; Sonnenblick, EH; Strom, J; Willens, H, 1982) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| "Rats, chronically treated with diazepam (4 mg/kg/day) for 28 days, displayed increased anxiety when tested in the elevated plus-maze, 42 hr after the last dose." | 3.68 | Concurrent treatment with verapamil prevents diazepam withdrawal-induced anxiety, in the absence of altered calcium flux in cortical synaptosomes. ( File, SE; Hitchcott, PK; Zharkovsky, A, 1992) |
| "Verapamil was used to isolate NMDA-dependent LTP." | 1.32 | Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus. ( Fathollahi, Y; Kazemnejad, A; Salmanzadeh, F; Semnanian, S; Shafizadeh, M, 2003) |
| "Although withdrawal symptoms have been reported following abrupt cessation of therapy with some cardiovascular drugs, there is no detailed report on similar complications of the cessation of therapy with calcium antagonists." | 1.27 | Rebound of vasospastic angina after cessation of long-term treatment with nifedipine. ( Gagnon, RM; Lemire, JG; Lette, J; Morissette, M, 1984) |
| "Verapamil is an effective and relatively-safe antihypertensive drug." | 1.27 | Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram. ( Beilin, LJ; Dimmitt, SB; Hockings, BE, 1988) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| "The verapamil-induced increase in peak left ventricular filling rate at rest (from 3." | 1.27 | Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: short- and long-term effects. ( Bacharach, SL; Bonow, RO; Dilsizian, V; Green, MV; Maron, BJ; Rosing, DR, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (42.86) | 18.7374 |
| 1990's | 11 (31.43) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, Y | 1 |
| Jin, L | 1 |
| Du, W | 1 |
| Meng, Y | 1 |
| Liang, J | 1 |
| Zhang, J | 1 |
| Sui, N | 1 |
| Shen, F | 1 |
| Peeters, LEJ | 1 |
| den Uil, CA | 1 |
| Feyz, L | 1 |
| van den Bemt, PMLA | 1 |
| Daemen, J | 1 |
| Versmissen, J | 1 |
| Oliveto, A | 1 |
| Mancino, M | 1 |
| Sanders, N | 1 |
| Cargile, C | 1 |
| Benjamin Guise, J | 1 |
| Bickel, W | 1 |
| Brooks Gentry, W | 1 |
| Kähkönen, S | 2 |
| Bondarenko, BB | 2 |
| Lipsanen, J | 1 |
| Zvartau, EE | 1 |
| Budzynska, B | 1 |
| Polak, P | 1 |
| Biala, G | 1 |
| Salmanzadeh, F | 1 |
| Fathollahi, Y | 1 |
| Semnanian, S | 1 |
| Shafizadeh, M | 1 |
| Kazemnejad, A | 1 |
| Leventhal, L | 1 |
| Cosmi, S | 1 |
| Deecher, D | 1 |
| Subramanian, VB | 1 |
| Bowles, MJ | 1 |
| Khurmi, NS | 1 |
| Davies, AB | 1 |
| O'Hara, MJ | 1 |
| Raftery, EB | 1 |
| Agoston, S | 1 |
| Maestrone, E | 1 |
| van Hezik, EJ | 1 |
| Ket, JM | 1 |
| Houwertjes, MC | 1 |
| Uges, DR | 1 |
| Lette, J | 1 |
| Gagnon, RM | 1 |
| Lemire, JG | 1 |
| Morissette, M | 1 |
| Frishman, WH | 1 |
| Klein, N | 1 |
| Strom, J | 1 |
| Cohen, MN | 1 |
| Shamoon, H | 1 |
| Willens, H | 1 |
| Klein, P | 1 |
| Roth, S | 1 |
| Iorio, L | 1 |
| LeJemtel, T | 1 |
| Pollack, S | 1 |
| Sonnenblick, EH | 1 |
| Barrios, M | 3 |
| Robles, I | 1 |
| Baeyens, JM | 4 |
| Rezvani, AH | 1 |
| Pucilowski, O | 1 |
| Grady, DR | 1 |
| Janowsky, D | 1 |
| O'Brien, RA | 1 |
| Shulman, A | 1 |
| Jagoda, J | 1 |
| Laycock, G | 1 |
| Kelly, H | 1 |
| Lazarova, M | 1 |
| Petkova, B | 1 |
| Staneva-Stoycheva, D | 1 |
| Blackburn-Munro, G | 1 |
| Brown, CH | 1 |
| Neumann, ID | 1 |
| Landgraf, R | 1 |
| Russell, JA | 1 |
| Schnur, P | 2 |
| Espinoza, M | 1 |
| Flores, R | 1 |
| Ortiz, S | 1 |
| Vallejos, S | 1 |
| Wainwright, M | 1 |
| Hitchcott, PK | 1 |
| Zharkovsky, A | 1 |
| File, SE | 1 |
| Little, HJ | 2 |
| Chugh, Y | 1 |
| Saha, N | 1 |
| Sankaranarayanan, A | 1 |
| Sharma, PL | 1 |
| Bell, A | 1 |
| Bala Subramanian, V | 1 |
| Mossier, M | 1 |
| Hasin, Y | 1 |
| Gotsman, MS | 1 |
| Bongianni, F | 1 |
| Carla, V | 1 |
| Moroni, F | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Dimmitt, SB | 1 |
| Beilin, LJ | 1 |
| Hockings, BE | 1 |
| Sosnowski, M | 1 |
| Markiewicz, A | 1 |
| Esposito, E | 1 |
| Ossowska, G | 1 |
| Samanin, R | 1 |
| Dolin, SJ | 1 |
| Halsey, MJ | 1 |
| Grey, DP | 1 |
| Bonow, RO | 1 |
| Dilsizian, V | 1 |
| Rosing, DR | 1 |
| Maron, BJ | 1 |
| Bacharach, SL | 1 |
| Green, MV | 1 |
1 review available for verapamil and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
4 trials available for verapamil and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Dr | 2013 |
Abrupt withdrawal of verapamil in ischaemic heart disease. The Danish Study Group on Verapamil in Myocardial Infarction.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; F | 1984 |
Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Catecholamines; Clinical Trials as Topic; | 1982 |
Calcium channel blocking drugs in the management of drug dependence, withdrawal and craving. A clinical pilot study with nifedipine and verapamil.
Topics: Adult; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Nifedipine; Pilot Projects; Subs | 1998 |
30 other studies available for verapamil and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Distinctive roles of L-type calcium channels subtypes within the dorsal hippocampus in formation of morphine withdrawal-induced aversion in rats.
Topics: Animals; Avoidance Learning; Calcium Channels, L-Type; Hippocampus; Morphine; Morphine Dependence; N | 2023 |
Acute calcium channel blocker withdrawal-induced cardiac arrest.
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Vasospasm; Diagnosis, Differential; Female; Hear | 2019 |
Effects of verapamil, an antagonist of L-type calcium channels, on cardiovascular symptoms in alcohol withdrawal.
Topics: Adult; Analysis of Variance; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Ele | 2008 |
Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Drug Administration Schedule; Flunarizine; Ma | 2012 |
Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Calcium Channel Blockers; Cognition; Electri | 2003 |
L-type Ca2+ channels mediate cardiovascular symptoms of alcohol withdrawal in humans.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System De | 2004 |
Effect of calcium channel modulators on temperature regulation in ovariectomized rats.
Topics: Amines; Animals; Body Temperature Regulation; Calcium Channel Blockers; Calcium Channels; Cyclohexan | 2005 |
Calcium antagonist withdrawal syndrome: objective demonstration with frequency-modulated ambulatory ST-segment monitoring.
Topics: Aged; Angina Pectoris; Calcium; Diltiazem; Electrocardiography; Female; Humans; Male; Middle Aged; M | 1983 |
Effective treatment of verapamil intoxication with 4-aminopyridine in the cat.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Antidotes; Blood Pressure; Cats; Heart Rate; Humans; Subst | 1984 |
Rebound of vasospastic angina after cessation of long-term treatment with nifedipine.
Topics: Adult; Angina Pectoris, Variant; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine | 1984 |
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats.
Topics: Alcohol Drinking; Animals; Biogenic Monoamines; Brain Chemistry; Calcium Channel Blockers; Dose-Resp | 1993 |
Effects of the calcium antagonists verapamil and nitrendipine on carbamazepine withdrawal.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Convulsants; Male; Nitrendipine; | 1999 |
Verapamil prevents withdrawal excitation of oxytocin neurones in morphine-dependent rats.
Topics: Animals; Animals, Suckling; Calcium Channel Blockers; Calcium Channels, L-Type; Electric Stimulation | 2000 |
Blocking naloxone-precipitated withdrawal in rats and hamsters.
Topics: Animals; Behavior, Animal; Clonidine; Cricetinae; Drug Implants; Mesocricetus; Morphine Dependence; | 1992 |
Concurrent treatment with verapamil prevents diazepam withdrawal-induced anxiety, in the absence of altered calcium flux in cortical synaptosomes.
Topics: Animals; Anxiety; Calcium; Calcium Radioisotopes; Cerebral Cortex; Diazepam; Male; Rats; Substance W | 1992 |
Morphine withdrawal in the hamster.
Topics: Animals; Clonidine; Cricetinae; Morphine; Naloxone; Nifedipine; Stereotyped Behavior; Substance With | 1992 |
Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Effect of peripheral administration of cinnarizine and verapamil on the abstinence syndrome in diazepam-dependent rats.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Cinnarizine; Diazepam; Female; Male; Motor Acti | 1992 |
Calcium channel blockers.
Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Combined Modality Therapy; Electroconvulsive Therapy; H | 1990 |
Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Clinical and research applications of ambulatory Holter ST-segment and heart rate monitoring.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Blood Pressure; Corona | 1986 |
Acute beta-blocker withdrawal and exchange by verapamil before percutaneous transluminal angioplasty.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon; Coronary Vasospasm; Humans; Substance Withdrawal | 1988 |
Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Methoxyhydroxyphenylglycol; Mo | 1986 |
Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram.
Topics: Adult; Coronary Angiography; Female; Humans; Hypertension; Myocardial Infarction; Substance Withdraw | 1988 |
[Withdrawal syndrome after discontinuation of calcium channel blockers].
Topics: Coronary Disease; Coronary Vasospasm; Humans; Nifedipine; Substance Withdrawal Syndrome; Verapamil | 1988 |
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats.
Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections, | 1987 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |
Rebound vasospasm after coronary bypass grafting.
Topics: Humans; Male; Middle Aged; Spasm; Substance Withdrawal Syndrome; Tibia; Vasoconstriction; Verapamil | 1985 |
Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: short- and long-term effects.
Topics: Adolescent; Adult; Aged; Cardiomyopathy, Hypertrophic; Diastole; Echocardiography; Female; Heart Ven | 1985 |