verapamil has been researched along with Skin Neoplasms in 10 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%." | 7.72 | Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma. ( Ake Hofer, P; Andersson, R; Henriksson, R; Riklund-Ahlström, K, 2003) |
| "Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%." | 3.72 | Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma. ( Ake Hofer, P; Andersson, R; Henriksson, R; Riklund-Ahlström, K, 2003) |
| "These results indicate that the anti-skin cancer effects of ursolic acid are enhanced with P-gp inhibitors." | 1.39 | Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. ( Junco, JJ; Kim, DJ; Liang, H; Malik, G; Mancha, A; Slaga, TJ; Wei, SJ, 2013) |
| "Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood." | 1.35 | Influence of melanosome dynamics on melanoma drug sensitivity. ( Cardarelli, CO; Chen, KG; Gottesman, MM; Hearing, VJ; Lai, B; Leapman, RD; Valencia, JC; Vieira, WD; Zhang, G, 2009) |
| "Murine CT-26 colon cancer cells growing in continuous culture (parental cells) were harvested and injected subcutaneously into the lateral flank (to produce subcutaneous tumors) or the lateral tail vein (to produce experimental lung metastases) of 10 8-week-old syngeneic male BALB/c mice." | 1.29 | Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. ( Bucana, CD; Dong, Z; Fan, D; Fidler, IJ; Radinsky, R; Tsan, R; Wilmanns, C, 1994) |
| " Therefore, the effects of the anthracycline antibiotics on skin tumor promotion were evaluated in combination with the Ca2+ antagonist verapamil (VRP) and the protein kinase C (PKC) inhibitor palmitoylcarnitine (PC), compounds known to circumvent drug resistance." | 1.28 | Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine. ( Perchellet, JP; Satyamoorthy, K, 1990) |
| " However, the chronic administration of ADR and DAU alone or in combination with VRP prior to the peak of TPA-induced DNA synthesis 16 h after each promotion treatment with TPA fails to alter the promotion of skin papillomas in the two-stage protocol of mouse skin carcinogenesis." | 1.28 | Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. ( Perchellet, JP; Satyamoorthy, K, 1989) |
| " Verapamil also potentiates the effect of a toxic conjugate formed between Pseudomonas exotoxin and a monoclonal antibody to the human transferrin receptor (anti-TFR-PE) and enhances the effect of Pseudomonas exotoxin (PE) alone." | 1.27 | Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin. ( Akiyama, S; Fitzgerald, DJ; Gottesman, MM; Hanover, JA; Pastan, I; Willingham, MC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Junco, JJ | 1 |
| Mancha, A | 1 |
| Malik, G | 1 |
| Wei, SJ | 1 |
| Kim, DJ | 1 |
| Liang, H | 1 |
| Slaga, TJ | 1 |
| Chen, KG | 1 |
| Leapman, RD | 1 |
| Zhang, G | 1 |
| Lai, B | 1 |
| Valencia, JC | 1 |
| Cardarelli, CO | 1 |
| Vieira, WD | 1 |
| Hearing, VJ | 1 |
| Gottesman, MM | 2 |
| Andersson, R | 1 |
| Ake Hofer, P | 1 |
| Riklund-Ahlström, K | 1 |
| Henriksson, R | 1 |
| Akiyama, S | 1 |
| Hanover, JA | 1 |
| Fitzgerald, DJ | 1 |
| Willingham, MC | 1 |
| Pastan, I | 1 |
| Dong, Z | 1 |
| Radinsky, R | 1 |
| Fan, D | 1 |
| Tsan, R | 1 |
| Bucana, CD | 1 |
| Wilmanns, C | 1 |
| Fidler, IJ | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
| Battalora, MS | 1 |
| Johnston, DA | 1 |
| DiGiovanni, J | 1 |
| Satyamoorthy, K | 2 |
| Perchellet, JP | 2 |
| Archer, CB | 1 |
| Greaves, MW | 1 |
10 other studies available for verapamil and Skin Neoplasms
| Article | Year |
|---|---|
Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line | 2013 |
Influence of melanosome dynamics on melanoma drug sensitivity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cisplatin; Cy | 2009 |
Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Dacarbazine; | 2003 |
Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin.
Topics: ADP Ribose Transferases; Antibodies, Monoclonal; Bacterial Toxins; Cell Line; Cell Survival; Diltiaz | 1984 |
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
The effects of calcium antagonists on anthrone skin tumor promotion and promoter-related effects in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Calcium; Calcium Channel Blockers; Carcinoge | 1995 |
Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine.
Topics: Animals; Daunorubicin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Induction; Fem | 1990 |
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Daunorubicin; DNA; Doxorubicin; | 1989 |
Assessment of treatment for painful cutaneous leiomyomas.
Topics: Adult; Humans; Leiomyoma; Male; Nifedipine; Pain; Pain Measurement; Phenoxybenzamine; Skin Neoplasms | 1987 |