verapamil has been researched along with Sensitivity and Specificity in 78 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This clinical study determines the effectiveness of verapamil hydrochloride on the prevention and treatment of keloids." | 9.10 | Prevention and treatment of keloids with intralesional verapamil. ( Baroni, A; Brongo, S; D'Andrea, F; Ferraro, G, 2002) |
| "Verapamil stimulation test was previously investigated as a tool for differential diagnosis of hyperprolactinemia, but with conflicting results." | 7.76 | Verapamil stimulation test in hyperprolactinemia: loss of prolactin response in anatomic or functional stalk effect. ( Dagdelen, S; Usman, A, 2010) |
| " The purpose of this study was to investigate the effects of verapamil and a tocopherol on reperfusion injury in the canine small bowel autotransplantation model." | 7.72 | The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion. ( Kilinç, K; Ozdemir, A; Ozenç, A; Yağmurdur, MC, 2003) |
| "This clinical study determines the effectiveness of verapamil hydrochloride on the prevention and treatment of keloids." | 5.10 | Prevention and treatment of keloids with intralesional verapamil. ( Baroni, A; Brongo, S; D'Andrea, F; Ferraro, G, 2002) |
| "002; multivariate analysis of variance), with 7 significant univariate treatment effects, all favoring COER-verapamil, being noted-pedal edema, polyuria, rapid heart beat or palpitations, hives, muscle cramps, abdominal cramps, and headaches." | 5.09 | Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life. ( Anderson, RB; Hollenberg, NK; Williams, GH, 1999) |
| "Verapamil stimulation test was previously investigated as a tool for differential diagnosis of hyperprolactinemia, but with conflicting results." | 3.76 | Verapamil stimulation test in hyperprolactinemia: loss of prolactin response in anatomic or functional stalk effect. ( Dagdelen, S; Usman, A, 2010) |
| " The purpose of this study was to investigate the effects of verapamil and a tocopherol on reperfusion injury in the canine small bowel autotransplantation model." | 3.72 | The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion. ( Kilinç, K; Ozdemir, A; Ozenç, A; Yağmurdur, MC, 2003) |
| "To evaluate the use of confocal microscopy in the study of resistance to epirubicin and to determine the effect of temperature, viability and a resistance-reversing agent on the intracellular distribution of this drug in sensitive and resistant derivatives of a superficial bladder cancer cell line." | 3.69 | Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study. ( Cooper, A; Duffy, PM; Gatrell, SK; Hayes, MC; Smart, CJ, 1996) |
| "Repeated administration of St John's wort significantly decreased the bioavailability of R- and S-verapamil." | 2.71 | St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. ( Bondesson, U; Engman, H; Hedeland, M; Knutson, L; Lennernäs, H; Tannergren, C, 2004) |
| "When verapamil hydrochloride was subjected to acid hydrolysis, oxidative, base hydrolysis, photolytic, and thermal stress, degradation was observed only in oxidative and base hydrolysis." | 1.46 | Analytical method development and validation for the analysis of verapamil hydrochloride and its related substances by using ultra perfomance liquid chromatography. ( Mahalingam, V; Vijayabaskar, S, 2017) |
| "All the 9 ventricular tachycardias (100%) terminated with adenosine, 2 of 2 terminated with verapamil, and 2 of 2 terminated with Valsalva." | 1.40 | Unifying mechanism of sustained idiopathic atrial and ventricular annular tachycardia. ( Cheung, JW; Ip, JE; Lerman, BB; Liu, CF; Markowitz, SM; Thomas, G, 2014) |
| "Cassette dosed plasma and brain samples from nine compounds were extracted using a protein precipitation method." | 1.39 | High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening. ( Dean, B; Deshmukh, G; Ding, X; Ghobarah, H; Hop, CE; Jaochico, A; Liederer, BM; Liu, X; Zhang, X, 2013) |
| "Verapamil was used as internal standard." | 1.38 | A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans. ( Gbotosho, GO; Happi, CT; Lawal, O; Oduola, A; Sijuade, A; Sowunmi, A, 2012) |
| " Thus, the proposed method is simple and suitable for the simultaneous analysis of active ingredients in dosage forms and human serum." | 1.37 | Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC. ( Arayne, MS; Mirza, AZ; Sultana, N, 2011) |
| "1 min and high clearance values suggesting that drug bioavailability will be considerably reduced, consequently affecting drug response and efficacy." | 1.35 | Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability. ( Beaudry, F; Vachon, P, 2009) |
| "Recent evidence has supported the cancer stem cell theory that cancer contains a small number of cancer stem cells (CSC) as a reservoir of cancer cells." | 1.34 | Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. ( Hayashi, Y; Kaneko, M; Kaneko, S; Komuro, H; Saihara, R; Shinya, M; Takita, J, 2007) |
| "Pretreatment with verapamil (10(-6) mol/L) or nickel (Ni(2+)) (2 mmol/L) inhibited the contractions to a magnitude of 63." | 1.32 | Application of electric field stimulation for investigations of human placental blood vessels. ( Falkay, G; Gáspár, R; Resch, BE, 2003) |
| "The mdr1 gene product P-glycoprotein (P-gp) is involved in the bioavailability and pharmacokinetics of various drugs." | 1.32 | (R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation. ( Boellaard, R; Franssen, EJ; Keizer, H; Lammertsma, AA; Luurtsema, G; Molthoff, CF; Smit, JW; Windhorst, AD, 2003) |
| " The presented method was successfully applied to an in vivo intestinal absorption and bioavailability study in humans, using the Loc-I-Gut method." | 1.32 | Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry. ( Bondesson, U; Fredriksson, E; Hedeland, M; Lennernäs, H, 2004) |
| "Verapamil was used as internal standard." | 1.31 | Quantitative determination of rocuronium in human plasma by liquid chromatography-electrospray ionization mass spectrometry. ( Aubagnac, JL; Audran, M; Bressolle, F; Enjalbal, C; Farenc, C; Martinez, J; Sanchez, P, 2001) |
| " In this situation, the selection of a correct assay dosage to study the MDR modulation mechanism was a problem." | 1.30 | Simultaneous determination of cytotoxic (adriamycin, vincristine) and modulator of resistance (verapamil, S 9788) drugs in human cells by high-performance liquid chromatography and ultraviolet detection. ( Atassi, G; Dubois, J; Hanocq, M; Tassin, JP, 1997) |
| "Dipyridamole-assessed CFR, was weakly related to parameters of exercise capacity." | 1.29 | Coronary flow reserve and exercise capacity in hypertrophic cardiomyopathy. ( Bodzoń, W; Dimitrow, PP; Dubiel, JS; Krzanowski, M; Szczeklik, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (34.62) | 18.2507 |
| 2000's | 39 (50.00) | 29.6817 |
| 2010's | 12 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duarte, N | 1 |
| Varga, A | 1 |
| Cherepnev, G | 1 |
| Radics, R | 1 |
| Molnár, J | 1 |
| Ferreira, MJ | 1 |
| Fong, WF | 1 |
| Shen, XL | 1 |
| Globisch, C | 1 |
| Wiese, M | 1 |
| Chen, GY | 1 |
| Zhu, GY | 1 |
| Yu, ZL | 1 |
| Tse, AK | 1 |
| Hu, YJ | 1 |
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 2 |
| Sun, Y | 1 |
| He, Z | 1 |
| Gao, Q | 1 |
| Huang, X | 1 |
| Jiang, Z | 2 |
| Liu, G | 1 |
| Xiao, Y | 1 |
| Sun, L | 1 |
| Wang, T | 1 |
| Zhang, L | 1 |
| Xie, S | 1 |
| Huang, H | 1 |
| Ip, JE | 1 |
| Liu, CF | 1 |
| Thomas, G | 1 |
| Cheung, JW | 1 |
| Markowitz, SM | 1 |
| Lerman, BB | 1 |
| Zheng, Y | 1 |
| Wang, Q | 1 |
| Wang, X | 2 |
| Chen, Y | 1 |
| Zhang, X | 2 |
| Bai, Z | 1 |
| Han, X | 1 |
| Zhang, Z | 2 |
| Vijayabaskar, S | 1 |
| Mahalingam, V | 1 |
| Pai, RK | 1 |
| Conant, AR | 1 |
| Dihmis, WC | 1 |
| Smith, NW | 1 |
| Ferguson, PD | 1 |
| Taylor, MR | 1 |
| Beaudry, F | 1 |
| Vachon, P | 1 |
| Yu, S | 1 |
| Crawford, E | 1 |
| Tice, J | 1 |
| Musselman, B | 1 |
| Wu, JT | 1 |
| Muzi, M | 1 |
| Mankoff, DA | 1 |
| Link, JM | 1 |
| Shoner, S | 1 |
| Collier, AC | 1 |
| Sasongko, L | 1 |
| Unadkat, JD | 1 |
| Rousu, T | 1 |
| Herttuainen, J | 1 |
| Tolonen, A | 1 |
| Dagdelen, S | 1 |
| Usman, A | 1 |
| Arayne, MS | 1 |
| Sultana, N | 1 |
| Mirza, AZ | 1 |
| Li, X | 1 |
| Zhu, D | 1 |
| You, T | 1 |
| Xu, W | 1 |
| Manicke, NE | 1 |
| Cooks, RG | 1 |
| Ouyang, Z | 1 |
| Gbotosho, GO | 1 |
| Happi, CT | 1 |
| Lawal, O | 1 |
| Sijuade, A | 1 |
| Sowunmi, A | 1 |
| Oduola, A | 1 |
| Singhal, P | 1 |
| Yadav, M | 1 |
| Winter, S | 1 |
| Guttikar, S | 1 |
| Patel, D | 1 |
| Mills, M | 1 |
| Shrivastav, PS | 1 |
| Ding, X | 1 |
| Ghobarah, H | 1 |
| Jaochico, A | 1 |
| Deshmukh, G | 1 |
| Liederer, BM | 1 |
| Hop, CE | 1 |
| Dean, B | 1 |
| Gmitrov, J | 1 |
| Ohkubo, C | 1 |
| Yue, H | 1 |
| Lee, JD | 1 |
| Shimizu, H | 1 |
| Uzui, H | 1 |
| Mitsuke, Y | 1 |
| Ueda, T | 1 |
| Resch, BE | 1 |
| Gáspár, R | 1 |
| Falkay, G | 1 |
| Luurtsema, G | 1 |
| Molthoff, CF | 1 |
| Windhorst, AD | 1 |
| Smit, JW | 1 |
| Keizer, H | 1 |
| Boellaard, R | 1 |
| Lammertsma, AA | 1 |
| Franssen, EJ | 1 |
| Yağmurdur, MC | 1 |
| Ozdemir, A | 1 |
| Ozenç, A | 1 |
| Kilinç, K | 1 |
| Mullett, WM | 1 |
| Walles, M | 2 |
| Levsen, K | 1 |
| Borlak, J | 1 |
| Pawliszyn, J | 1 |
| Kimura, Y | 1 |
| Shibasaki, S | 1 |
| Morisato, K | 1 |
| Ishizuka, N | 1 |
| Minakuchi, H | 1 |
| Nakanishi, K | 1 |
| Matsuo, M | 1 |
| Amachi, T | 1 |
| Ueda, M | 1 |
| Ueda, K | 1 |
| Tannergren, C | 1 |
| Engman, H | 1 |
| Knutson, L | 1 |
| Hedeland, M | 2 |
| Bondesson, U | 2 |
| Lennernäs, H | 2 |
| Fredriksson, E | 1 |
| Sarica, K | 1 |
| Erbagci, A | 1 |
| Yağci, F | 1 |
| Bakir, K | 1 |
| Erturhan, S | 1 |
| Uçak, R | 1 |
| Salo, PK | 1 |
| Salomies, H | 1 |
| Harju, K | 1 |
| Ketola, RA | 2 |
| Kotiaho, T | 2 |
| Yli-Kauhaluoma, J | 1 |
| Kostiainen, R | 2 |
| Leclercq, L | 1 |
| Delatour, C | 1 |
| Hoes, I | 1 |
| Brunelle, F | 1 |
| Labrique, X | 1 |
| Castro-Perez, J | 1 |
| do C Borges, NC | 1 |
| Mendes, GD | 1 |
| Barrientos-Astigarraga, RE | 1 |
| Galvinas, P | 1 |
| Oliveira, CH | 1 |
| De Nucci, G | 1 |
| Stehfest, E | 1 |
| Torky, A | 1 |
| Glahn, F | 1 |
| Foth, H | 1 |
| Venkatesh, G | 1 |
| Ramanathan, S | 1 |
| Mansor, SM | 1 |
| Nair, NK | 1 |
| Sattar, MA | 1 |
| Croft, SL | 1 |
| Navaratnam, V | 1 |
| Pedraglio, S | 1 |
| Rozio, MG | 1 |
| Misiano, P | 1 |
| Reali, V | 1 |
| Dondio, G | 1 |
| Bigogno, C | 1 |
| Yong, WW | 1 |
| Sourial, M | 1 |
| Farmer, PJ | 1 |
| Southwell, BR | 1 |
| Hutson, JM | 1 |
| Pól, J | 1 |
| Kauppila, TJ | 1 |
| Haapala, M | 1 |
| Saarela, V | 1 |
| Franssila, S | 1 |
| Gauvin, C | 1 |
| Morin, PE | 1 |
| Panetta, R | 1 |
| Ducharme, J | 1 |
| Gueret, G | 1 |
| Pennec, JP | 1 |
| Arvieux, CC | 1 |
| Nemes, P | 1 |
| Vertes, A | 1 |
| Komuro, H | 1 |
| Saihara, R | 1 |
| Shinya, M | 1 |
| Takita, J | 1 |
| Kaneko, S | 1 |
| Kaneko, M | 1 |
| Hayashi, Y | 1 |
| Bjorkander, I | 1 |
| Forslund, L | 1 |
| Kahan, T | 1 |
| Ericson, M | 1 |
| Held, C | 1 |
| Rehnqvist, N | 1 |
| Hjemdahl, P | 1 |
| Frey, T | 1 |
| Yue, S | 1 |
| Haugland, RP | 1 |
| Hayashi, T | 1 |
| Hirono, C | 1 |
| Young, JA | 1 |
| Cook, DI | 1 |
| Stagni, G | 1 |
| Gillespie, WR | 1 |
| Gottesman, MM | 1 |
| Mickisch, GH | 1 |
| Pastan, I | 1 |
| Dethy, JM | 1 |
| De Broux, S | 1 |
| Lesne, M | 1 |
| Longstreth, J | 1 |
| Gilbert, P | 1 |
| Morganroth, J | 1 |
| Waldman, SA | 1 |
| Muscará, MN | 1 |
| de-Nucci, G | 1 |
| Finkel, MS | 1 |
| Shen, L | 1 |
| Oddis, CV | 1 |
| Romeo, RC | 1 |
| Tendera, M | 1 |
| Schneeweiss, A | 1 |
| Bartoszewski, A | 1 |
| Polonski, L | 1 |
| Wodniecki, J | 1 |
| Salamon, A | 1 |
| Broxterman, HJ | 1 |
| Sonneveld, P | 1 |
| Feller, N | 1 |
| Ossenkoppele, GJ | 1 |
| Währer, DC | 1 |
| Eekman, CA | 1 |
| Schoester, M | 1 |
| Lankelma, J | 1 |
| Pinedo, HM | 1 |
| Löwenberg, B | 1 |
| Schuurhuis, GJ | 1 |
| Shin, HS | 1 |
| Oh-Shin, YS | 1 |
| Kim, HJ | 1 |
| Kang, YK | 1 |
| Duffy, PM | 1 |
| Hayes, MC | 1 |
| Gatrell, SK | 1 |
| Cooper, A | 1 |
| Smart, CJ | 1 |
| Borderies, JR | 1 |
| Jiménez, M | 1 |
| Angel, F | 1 |
| Dimitrow, PP | 1 |
| Krzanowski, M | 1 |
| Bodzoń, W | 1 |
| Szczeklik, A | 1 |
| Dubiel, JS | 1 |
| Mangani, F | 1 |
| Luck, G | 1 |
| Fraudeau, C | 1 |
| Vérette, E | 1 |
| Valvo, L | 1 |
| Alimenti, R | 1 |
| Alimonti, S | 1 |
| Raimondi, S | 1 |
| Foglietta, F | 1 |
| Campana, F | 1 |
| Tassin, JP | 1 |
| Dubois, J | 1 |
| Atassi, G | 2 |
| Hanocq, M | 1 |
| Garcia, MA | 1 |
| Aramayona, JJ | 1 |
| Bregante, MA | 1 |
| Fraile, LJ | 1 |
| Solans, C | 1 |
| Silverman, JA | 1 |
| Hayes, ML | 1 |
| Luft, BJ | 1 |
| Joiner, KA | 1 |
| Maynadié, M | 1 |
| Matutes, E | 1 |
| Catovsky, D | 1 |
| Elbling, L | 1 |
| Berger, W | 1 |
| Weiss, RM | 1 |
| Printz, D | 1 |
| Fritsch, G | 1 |
| Micksche, M | 1 |
| Lehnert, M | 1 |
| de Giuli, R | 1 |
| Twentyman, PR | 1 |
| Anderson, RB | 1 |
| Hollenberg, NK | 1 |
| Williams, GH | 1 |
| von Richter, O | 1 |
| Eichelbaum, M | 1 |
| Schönberger, F | 1 |
| Hofmann, U | 1 |
| Farenc, C | 1 |
| Enjalbal, C | 1 |
| Sanchez, P | 1 |
| Bressolle, F | 1 |
| Audran, M | 1 |
| Martinez, J | 1 |
| Aubagnac, JL | 1 |
| Michelucci, A | 1 |
| Lazzeri, C | 1 |
| Padeletti, L | 1 |
| Bagliani, G | 1 |
| Colella, A | 1 |
| Sabini, A | 1 |
| Zipoli, R | 1 |
| Costoli, A | 1 |
| Pieragnoli, P | 1 |
| Gensini, GF | 1 |
| Franchi, F | 1 |
| Maruyama, M | 1 |
| Tadera, T | 1 |
| Miyamoto, S | 1 |
| Ino, T | 1 |
| Crego, AL | 1 |
| Gómez, J | 1 |
| Marina, ML | 1 |
| Lavandera, JL | 1 |
| Hill, RE | 1 |
| Heard, K | 1 |
| Bogdan, GM | 1 |
| Cairns, CB | 1 |
| Dart, RC | 1 |
| Kuroda, Y | 1 |
| Cao, B | 1 |
| Shibukawa, A | 1 |
| Nakagawa, T | 1 |
| D'Andrea, F | 1 |
| Brongo, S | 1 |
| Ferraro, G | 1 |
| Baroni, A | 1 |
| Léonce, S | 1 |
| Pierré, A | 1 |
| Anstett, M | 1 |
| Pérez, V | 1 |
| Genton, A | 1 |
| Bizzari, JP | 1 |
| Brunette, MG | 1 |
| Leclerc, M | 1 |
| Lensmeyer, GL | 1 |
| Wiebe, DA | 1 |
| Doran, TC | 1 |
| Lacroix, PM | 1 |
| Graham, SJ | 1 |
| Lovering, EG | 1 |
1 review available for verapamil and Sensitivity and Specificity
| Article | Year |
|---|---|
In vivo models of P-glycoprotein-mediated multidrug resistance.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub | 1994 |
5 trials available for verapamil and Sensitivity and Specificity
| Article | Year |
|---|---|
St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Biological Availability; Dose-R | 2004 |
Differential index: a simple time domain heart rate variability analysis with prognostic implications in stable angina pectoris.
Topics: Aged; Angina Pectoris; Cause of Death; Dose-Response Relationship, Drug; Double-Blind Method; Drug A | 2008 |
Measurement of plasma verapamil levels by high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Fluorometry; Humans; Male; | 1993 |
Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Constipation; Dou | 1999 |
Prevention and treatment of keloids with intralesional verapamil.
Topics: Administration, Topical; Adult; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Inject | 2002 |
72 other studies available for verapamil and Sensitivity and Specificity
| Article | Year |
|---|---|
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter | 2007 |
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Mem | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
A rapid and sensitive LC-ESI-MS/MS method for the detection of YF-49-92.MLS in rat plasma.
Topics: Acetates; Animals; Antitubercular Agents; Calibration; Chromatography, Liquid; Female; Formates; Imi | 2013 |
Unifying mechanism of sustained idiopathic atrial and ventricular annular tachycardia.
Topics: Adenosine; Adult; Aged; Cohort Studies; Electrocardiography; Electrophysiologic Techniques, Cardiac; | 2014 |
Development and Application of Zirconia Coated Paper Substrate for High Sensitivity Analysis of Therapeutic Drugs in Dried Blood Spots.
Topics: Amitriptyline; Animals; Cattle; Dried Blood Spot Testing; Heterocyclic Compounds; Humans; Mass Spect | 2016 |
Analytical method development and validation for the analysis of verapamil hydrochloride and its related substances by using ultra perfomance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Contamination; Drug Stabil | 2017 |
Treatment with phenoxybenzamine may lead to loss of endothelial viability in radial artery.
Topics: Coronary Artery Bypass; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Follow-Up S | 2008 |
Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC.
Topics: Acrylates; Amitriptyline; Aniline Compounds; Chromatography, High Pressure Liquid; Chromatography, I | 2008 |
Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability.
Topics: Animals; Capsaicin; Chromatography, Liquid; Dogs; Drug Stability; Linear Models; Metabolic Clearance | 2009 |
Bioanalysis without sample cleanup or chromatography: the evaluation and initial implementation of direct analysis in real time ionization mass spectrometry for the quantification of drugs in biological matrixes.
Topics: Animals; Humans; Mass Spectrometry; Mice; Pharmaceutical Preparations; Rats; Reproducibility of Resu | 2009 |
Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans.
Topics: Adult; Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Bra | 2009 |
Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds.
Topics: Amitriptyline; Biochemical Phenomena; Drug Discovery; False Negative Reactions; Humans; Mass Spectro | 2010 |
Verapamil stimulation test in hyperprolactinemia: loss of prolactin response in anatomic or functional stalk effect.
Topics: Adult; Biomarkers; Case-Control Studies; Diagnosis, Differential; Female; Humans; Hyperprolactinemia | 2010 |
Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Glyburide; Humans; Linear Model | 2011 |
Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach.
Topics: Analysis of Variance; Cardiovascular Agents; Electrophoresis, Capillary; Female; Humans; Hydrogen-Io | 2011 |
Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots.
Topics: Blood Specimen Collection; Drug Monitoring; Humans; Mass Spectrometry; Paper; Pharmaceutical Prepara | 2012 |
A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Black People; Chromatography, | 2012 |
Enantiomeric separation of verapamil and its active metabolite, norverapamil, and simultaneous quantification in human plasma by LC-ESI-MS-MS.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Liquid- | 2012 |
High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Citalopram; Drug Discovery; Drug Evaluation, Precl | 2013 |
Verapamil protective effect on natural and artificial magnetic field cardiovascular impact.
Topics: Animals; Baroreflex; Blood Pressure; Carotid Sinus; Earth, Planet; Heart Rate; Magnetics; Male; Pres | 2002 |
Effects of magnesium on the production of extracellular matrix metalloproteinases in cultured rat vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Magn | 2003 |
Application of electric field stimulation for investigations of human placental blood vessels.
Topics: Adult; Animals; Culture Techniques; Electric Stimulation; Female; Gestational Age; Humans; Mesenteri | 2003 |
(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.
Topics: Alcohol Oxidoreductases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Bra | 2003 |
The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Disease Models, Animal; Dogs; Hypertonic Solutions; | 2003 |
Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography-mass spectrometry.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Gallopamil; Male; Mass Spectrometry; | 2004 |
Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column.
Topics: Adenosine Diphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; | 2004 |
Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Biological Availability; Calcium Channel Blockers; Humans; Intestinal Absorption; Mass Spectrometry; | 2004 |
Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria.
Topics: Allopurinol; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Hyperoxaluria; In Situ Nic | 2004 |
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Atmospheric Pressure; Chromatography, Thin Layer; Metoprolol; Midazolam; Models, Molecular; Molecula | 2005 |
Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Humans; Ketotifen | 2005 |
Verapamil quantification in human plasma by liquid chromatography coupled to tandem mass spectrometry. An application for bioequivalence study.
Topics: Chromatography, Liquid; Drug Stability; Humans; Reproducibility of Results; Sensitivity and Specific | 2005 |
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionin | 2006 |
Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies.
Topics: Animals; Antiprotozoal Agents; Atenolol; Buffers; Chromatography, High Pressure Liquid; Drug Stabili | 2007 |
New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies.
Topics: Administration, Oral; Animals; Benzamides; Calibration; Cells, Cultured; Chromatography, High Pressu | 2007 |
Does chemical sympathectomy alter the ontogeny of gubernacular migration in vivo?
Topics: Analysis of Variance; Animals; Animals, Newborn; Biopsy, Needle; Cryptorchidism; Disease Models, Ani | 2007 |
Microchip sonic spray ionization.
Topics: Angiotensin I; Ibuprofen; Lab-On-A-Chip Devices; Microchip Analytical Procedures; Quaternary Ammoniu | 2007 |
Comparison of sub-2-microm particle columns for fast metabolite ID.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structur | 2007 |
Hemodynamic effects of intralipid after verapamil intoxication may be due to a direct effect of fatty acids on myocardial calcium channels.
Topics: Animals; Calcium Channels; Disease Models, Animal; Dogs; Drug-Related Side Effects and Adverse React | 2007 |
Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry.
Topics: Atmospheric Pressure; Humans; Molecular Weight; Particle Size; Plant Leaves; Plant Roots; Plant Stem | 2007 |
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Topics: Cell Division; Cell Line, Tumor; Cell Separation; Child; Child, Preschool; Drug Resistance, Neoplasm | 2007 |
Dyes providing increased sensitivity in flow-cytometric dye-efflux assays for multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Calcium Channel | 1995 |
The ACh-induced whole-cell currents in sheep parotid secretory cells. Do BK channels really carry the ACh-evoked whole-cell K+ current?
Topics: 4-Aminopyridine; Acetylcholine; Animals; Barium; Cell Membrane; Chlorides; Parotid Gland; Patch-Clam | 1995 |
Simultaneous analysis of verapamil and norverapamil enantiomers in human plasma by high-performance liquid chromatography.
Topics: Acetonitriles; Acetylation; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration | 1995 |
Stereoselective determination of verapamil and norverapamil by capillary electrophoresis.
Topics: Capillary Action; Electrophoresis; Humans; Hydrogen-Ion Concentration; Quality Control; Sensitivity | 1994 |
Sensitivity in detecting drug-induced alterations in the PR interval: comparison of the surface electrocardiogram measured by a cardiologist versus routine automated computer analysis.
Topics: Cardiology; Delayed-Action Preparations; Diagnosis, Computer-Assisted; Electrocardiography; Humans; | 1993 |
Verapamil regulation of a defective SR release channel in the cardiomyopathic Syrian hamster.
Topics: Animals; Calcium; Calcium Channels; Cardiomyopathy, Dilated; Cardiotonic Agents; Cricetinae; Disease | 1993 |
The acute response of left ventricular filling dynamics to intravenous verapamil predicts the changes in exercise tolerance after oral verapamil therapy in patients with hypertrophic cardiomyopathy.
Topics: Administration, Oral; Adult; Aged; Cardiomyopathy, Hypertrophic; Diastole; Exercise Tolerance; Femal | 1993 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; | 1996 |
Sensitive assay for verapamil in plasma using gas-liquid chromatography with nitrogen-phosphorus detection.
Topics: Adult; Calcium Channel Blockers; Chromatography, Gas; Female; Humans; Male; Nitrogen; Phosphorus; Se | 1996 |
Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study.
Topics: Administration, Intravesical; Antibiotics, Antineoplastic; Drug Resistance, Multiple; Drug Resistanc | 1996 |
Non-adrenergic, non-cholinergic inhibitory junction potential in rat colonic circular muscle is partly sensitive to omega-conotoxin GVIA and resistant to L-, P- or Q-type calcium channel blockers.
Topics: Adrenergic Fibers; Animals; Calcium; Calcium Channel Blockers; Cholinergic Fibers; Colon; Electric S | 1996 |
Coronary flow reserve and exercise capacity in hypertrophic cardiomyopathy.
Topics: Adult; Blood Flow Velocity; Cardiomyopathy, Hypertrophic; Coronary Circulation; Dipyridamole; Echoca | 1996 |
On-line column-switching high-performance liquid chromatography analysis of cardiovascular drugs in serum with automated sample clean-up and zone-cutting technique to perform chiral separation.
Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Lidocaine; Linear Models; Me | 1997 |
Development and validation of a liquid chromatographic method for the determination of related substances in verapamil hydrochloride.
Topics: Calcium Channel Blockers; Chromatography, Liquid; Drug Stability; Reproducibility of Results; Sensit | 1997 |
Simultaneous determination of cytotoxic (adriamycin, vincristine) and modulator of resistance (verapamil, S 9788) drugs in human cells by high-performance liquid chromatography and ultraviolet detection.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Doxorubici | 1997 |
Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Rabbits; Sensitivity and Sp | 1997 |
Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chloroce | 1997 |
Quantification of P-glycoprotein in chronic lymphocytic leukemia by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cas | 1997 |
A novel bioassay for P-glycoprotein functionality using cytochalasin D.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding | 1998 |
Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Breast Neoplasms; Cyclosp | 1996 |
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.
Topics: Body Fluids; Chromatography, High Pressure Liquid; Deuterium; Humans; Intestinal Mucosa; Mass Spectr | 2000 |
Quantitative determination of rocuronium in human plasma by liquid chromatography-electrospray ionization mass spectrometry.
Topics: Androstanols; Chromatography, Liquid; Humans; Neuromuscular Blocking Agents; Reference Standards; Re | 2001 |
Altered values of heart rate variability in patients with relapse of atrial fibrillation during the first week after electrical cardioversion: preliminary data.
Topics: Aged; Amiodarone; Atrial Fibrillation; Circadian Rhythm; Electric Countershock; Electrocardiography, | 2001 |
Demonstration of the reentrant circuit of verapamil-sensitive idiopathic left ventricular tachycardia: direct evidence for macroreentry as the underlying mechanism.
Topics: Adult; Anti-Arrhythmia Agents; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Huma | 2001 |
Application of capillary zone electrophoresis with off-line solid-phase extraction to in vitro metabolism studies of antifungals.
Topics: Acetic Acid; Acetonitriles; Antifungal Agents; Clotrimazole; Drug Stability; Electrophoresis, Capill | 2001 |
Attenuation of verapamil-induced myocardial toxicity in an ex-vivo rat model using a verapamil-specific ovine immunoglobin.
Topics: Animals; Calcium Channel Blockers; Cardiomyopathies; Drug Therapy, Combination; Immunoglobulin G; Ma | 2001 |
Effect of oxidation of low-density lipoprotein on drug binding affinity studied by high performance frontal analysis-capillary electrophoresis.
Topics: Calcium Channel Blockers; Electrophoresis, Capillary; Lipoproteins, LDL; Molecular Structure; Nifedi | 2001 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe | 1992 |
Ca2+ transport through the brush border membrane of human placenta syncytiotrophoblasts.
Topics: Adenosine Triphosphate; Biological Transport; Calcium; Calcium Radioisotopes; Calcium-Binding Protei | 1992 |
Application of the Empore solid-phase extraction membrane to the isolation of drugs from blood: II. Mexiletine and flecainide.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flecainide; Humans; Membrane | 1992 |
High-performance liquid chromatographic method for the assay of verapamil hydrochloride and related compounds in raw material.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Molecular Structure; Reproducibility of Result | 1991 |