verapamil has been researched along with Sarcoma, Epithelioid in 10 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of multi-drug resistance (MDR1) and its product, P-glycoprotein (P-gp) on 5-aminolevulinic acid hexyl ester (Hexyl-ALA) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5." | 7.74 | Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells. ( Chu, ES; Ho, RJ; Shi, M; Yow, CM, 2008) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 5.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| "We present data from a pilot study in 10 soft-tissue sarcoma patients imaged with (11)C-thymidine for cellular proliferation, (18)F-fluoromisonidazole (FMISO) for tissue hypoxia, and (11)C-verapamil for P-glycoprotein activity, in comparison with (15)O-water for blood flow and (11)C-CO(2) for metabolite analysis and (18)F-FDG clinical scans." | 3.77 | Multiagent PET for risk characterization in sarcoma. ( Conrad, EU; Eary, JF; Krohn, KA; Link, JM; Mankoff, DA; Muzi, M; White, JK, 2011) |
| "The role of multi-drug resistance (MDR1) and its product, P-glycoprotein (P-gp) on 5-aminolevulinic acid hexyl ester (Hexyl-ALA) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5." | 3.74 | Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells. ( Chu, ES; Ho, RJ; Shi, M; Yow, CM, 2008) |
| "Dexverapamil is a competitive inhibitor of the P-glycoprotein (Pgp) efflux pump, a potent mechanism of multidrug resistance (mdr-1) in vitro." | 2.68 | Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy. ( Balis, FM; Bates, SE; Bryant, G; Chabner, BA; Jamis-Dow, C; Klecker, RW; Kohler, DR; Steinberg, SM; Wilson, WH; Wittes, RE, 1995) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 1.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Min, KH | 1 |
| Xia, Y | 1 |
| Kim, EK | 1 |
| Jin, Y | 1 |
| Kaur, N | 1 |
| Kim, ES | 1 |
| Kim, DK | 1 |
| Jung, HY | 1 |
| Choi, Y | 1 |
| Park, MK | 1 |
| Min, YK | 1 |
| Lee, K | 2 |
| Pósa, SP | 1 |
| Dargó, G | 1 |
| Nagy, S | 1 |
| Kisszékelyi, P | 1 |
| Garádi, Z | 1 |
| Hámori, L | 1 |
| Szakács, G | 1 |
| Kupai, J | 1 |
| Tóth, S | 1 |
| Tcherniuk, SO | 1 |
| Oleinikov, AV | 1 |
| Chu, ES | 1 |
| Yow, CM | 1 |
| Shi, M | 1 |
| Ho, RJ | 1 |
| Eary, JF | 1 |
| Link, JM | 1 |
| Muzi, M | 1 |
| Conrad, EU | 1 |
| Mankoff, DA | 1 |
| White, JK | 1 |
| Krohn, KA | 1 |
| Wilson, WH | 1 |
| Jamis-Dow, C | 1 |
| Bryant, G | 1 |
| Balis, FM | 1 |
| Klecker, RW | 1 |
| Bates, SE | 1 |
| Chabner, BA | 1 |
| Steinberg, SM | 1 |
| Kohler, DR | 1 |
| Wittes, RE | 1 |
| Chen, G | 1 |
| Durán, GE | 1 |
| Steger, KA | 1 |
| Lacayo, NJ | 1 |
| Jaffrézou, JP | 1 |
| Dumontet, C | 1 |
| Sikic, BI | 1 |
| Rodrigues, M | 1 |
| Kalinowska, W | 1 |
| Zielinski, C | 1 |
| Sinzinger, H | 1 |
| Okada, T | 1 |
| El-Mehasseb, IM | 1 |
| Kodaka, M | 1 |
| Tomohiro, T | 1 |
| Okamoto, K | 1 |
| Okuno, H | 1 |
| Tsuchiya, H | 1 |
| Tomita, K | 1 |
1 trial available for verapamil and Sarcoma, Epithelioid
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Cyclophosphamide; D | 1995 |
9 other studies available for verapamil and Sarcoma, Epithelioid
| Article | Year |
|---|---|
A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives.
Topics: Adamantane; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P- | 2009 |
Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cinchona Alkaloids; Doxor | 2022 |
Pgp efflux pump decreases the cytostatic effect of CENP-E inhibitor GSK923295.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfami | 2015 |
Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter | 2008 |
Multiagent PET for risk characterization in sarcoma.
Topics: Carbon Dioxide; Feasibility Studies; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assi | 2011 |
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; | 1997 |
Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Cell Line; Cell Survival; Female; Humans | 2001 |
Mononuclear platinum(II) complex with 2-phenylpyridine ligands showing high cytotoxicity against mouse sarcoma 180 cells acquiring high cisplatin resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Divisi | 2001 |
[The combined effect of anti-tumor agents with caffeine or calcium channel blockers on sarcoma cells by clonogenic assay].
Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Calcium Channel Blockers; Colony-Forming U | 1987 |