Page last updated: 2024-10-24

verapamil and Rhabdomyosarcoma

verapamil has been researched along with Rhabdomyosarcoma in 4 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)

Research Excerpts

ExcerptRelevanceReference
"The effect of the calcium channel blocker verapamil (VRP) on the accumulation and retention of vincristine (VCR) has been examined in mice bearing xenografts of human rhabdomyosarcomas."3.67Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts. ( Horowitz, ME; Horton, JK; Houghton, JA; Houghton, PJ; Thimmaiah, KN, 1989)
"Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion."2.68Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995)
"Recent evidence has supported the cancer stem cell theory that cancer contains a small number of cancer stem cells (CSC) as a reservoir of cancer cells."1.34Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. ( Hayashi, Y; Kaneko, M; Kaneko, S; Komuro, H; Saihara, R; Shinya, M; Takita, J, 2007)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Komuro, H1
Saihara, R1
Shinya, M1
Takita, J1
Kaneko, S1
Kaneko, M1
Hayashi, Y1
Cowie, FJ2
Pinkerton, CR2
Phillips, M1
Dick, G1
Judson, I1
McCarthy, PT1
Flanagan, RJ1
Pritchard-Jones, K1
Renshaw, J1
Horton, JK1
Thimmaiah, KN1
Houghton, JA1
Horowitz, ME1
Houghton, PJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer[NCT00001338]Phase 365 participants Interventional1993-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for verapamil and Rhabdomyosarcoma

ArticleYear
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
    British journal of cancer, 1995, Volume: 71, Issue:4

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis

1995

Other Studies

3 other studies available for verapamil and Rhabdomyosarcoma

ArticleYear
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
    Journal of pediatric surgery, 2007, Volume: 42, Issue:12

    Topics: Cell Division; Cell Line, Tumor; Cell Separation; Child; Child, Preschool; Drug Resistance, Neoplasm

2007
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
    International journal of oncology, 1998, Volume: 12, Issue:5

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel

1998
Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts.
    Biochemical pharmacology, 1989, Jun-01, Volume: 38, Issue:11

    Topics: Animals; Biotransformation; Drug Resistance; Humans; Mice; Neoplasm Transplantation; Rhabdomyosarcom

1989