Page last updated: 2024-10-24

verapamil and Retinoblastoma

verapamil has been researched along with Retinoblastoma in 3 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

Research Excerpts

ExcerptRelevanceReference
"The chemosensitizing effects of cyclosporin A and verapamil on the cytotoxicity of adriamycin were investigated using MTT assay against two human retinoblastoma cell lines, Y79 and WERI-Rb-1."7.68Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines. ( Hong, WS; Kim, CM; Lee, TW; Yang, SW; Youn, DH, 1993)
"The chemosensitizing effects of cyclosporin A and verapamil on the cytotoxicity of adriamycin were investigated using MTT assay against two human retinoblastoma cell lines, Y79 and WERI-Rb-1."3.68Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines. ( Hong, WS; Kim, CM; Lee, TW; Yang, SW; Youn, DH, 1993)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Abruzzo, T1
Abraham, K1
Karani, KB1
Geller, JI2
Vadivelu, S1
Racadio, JM1
Zhang, B1
Correa, ZM2
Abruzzo, TA1
Kimbrough, DA1
Michaels, S1
Cornell, K1
Augsburger, JJ1
Lee, TW1
Yang, SW1
Kim, CM1
Hong, WS1
Youn, DH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma[NCT01466855]Early Phase 136 participants (Actual)Interventional2011-10-31Terminated (stopped due to Competing studies)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for verapamil and Retinoblastoma

ArticleYear
Adjunctive techniques for optimization of ocular hemodynamics in children undergoing ophthalmic artery infusion chemotherapy.
    Journal of neurointerventional surgery, 2015, Volume: 7, Issue:10

    Topics: Adolescent; Antineoplastic Agents; Balloon Occlusion; Carotid Artery, External; Carotid Artery, Inte

2015

Other Studies

2 other studies available for verapamil and Retinoblastoma

ArticleYear
Correlation of Technical and Adjunctive Factors with Quantitative Tumor Reduction in Children Undergoing Selective Ophthalmic Artery Infusion Chemotherapy for Retinoblastoma.
    AJNR. American journal of neuroradiology, 2021, Volume: 42, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Child; Child, Preschool; Cohort Studies; Female; Fluoroscopy; Hum

2021
Chemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines.
    Journal of Korean medical science, 1993, Volume: 8, Issue:2

    Topics: Cell Survival; Cyclosporine; Doxorubicin; Eye Neoplasms; Humans; Retinoblastoma; Tumor Cells, Cultur

1993