Page last updated: 2024-10-24

verapamil and Reperfusion Injury

verapamil has been researched along with Reperfusion Injury in 72 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
" Thirty-nine patients were injected with Verapamil through the mesenteric vein before Pringle's maneuver to alleviate hepatic ischemia-reperfusion injury, while 47 patients were not."9.14Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"Male SD rats were randomly divided into five groups: false operation (group A); rats subjected to 50%hepatectomy and 45 min of hepatic ischemia (group B); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with isoglycyrrhizinate (group C); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with verapamil (group D); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with isoglycyrrhizinate and verapamil (group E)."7.81[Protective effect of magnesium isoglycyrrhizinate combinated with verapamil on liver ischemia-reperfusion injury after semi-hepatectomy in rats]. ( Chen, Z; Hu, C; Huang, C; Li, W; Qin, F; Shen, S; Tan, G, 2015)
" We evaluated postoperative outcome of patients subjected to standard ANL that received 10 mg of Verapamil immediately before declamping renal artery, due to prevention of reperfusion injury."7.74Using verapamil as protective factor in renal ischemia reperfusion injury during anatrophic nephrolithotomy. ( Aganović, D; Hadziosmanović, O; Kulovac, B; Prcić, A, 2007)
"To observe the protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils."7.74[Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils]. ( Ding, N; Wang, DF; Wang, F; Xiao, H, 2007)
" The purpose of this study was to investigate the effects of verapamil and a tocopherol on reperfusion injury in the canine small bowel autotransplantation model."7.72The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion. ( Kilinç, K; Ozdemir, A; Ozenç, A; Yağmurdur, MC, 2003)
" This retrospective study investigates the efficacy of therapy with intracoronary verapamil to terminate reperfusion-induced ventricular tachyarrhythmias in patients with acute myocardial infarction (AMI)."7.72Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction. ( Dote, K; Habara, S; Hasegawa, D; Kato, M; Sasaki, S; Takemoto, H, 2004)
"In this prospective controlled study, the aim was to examine the effects of vitamin C, mannitol and verapamil on adnexial ischaemia-reperfusion injury in the rat ovary."7.71Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil. ( Apan, A; Kisa, U; Sağsöz, N, 2002)
"We studied the effect of verapamil on intestinal ischemia and reperfusion (I/R) injury."7.70Beneficial effects of verapamil on intestinal ischemia and reperfusion injury: pretreatment versus postischemic treatment. ( Fujii, Y; Kataoka, M; Kato, T; Kimura, M; Kuwabara, Y; Narita, K; Okahira, T; Sato, A, 1998)
"Using the model of the isolated perfused rat liver, we investigated the influence of the two pharmacologically different calcium channel blockers, verapamil and flunarizine, on changes of ion homeostasis, liver weights, pH deviations and enzyme activities during warm ischemia (37 degrees C) and reperfusion."7.69Verapamil and flunarizine protect the isolated perfused rat liver against warm ischemia and reperfusion injury. ( Bloechle, C; Broelsch, CE; Haller, G; Konrad, T; Kusterer, K; Usadel, KH, 1995)
" Therefore the effect of pretreatment by nicergoline and bromocriptine was established in ischemia-reperfusion injury of rat liver."7.69The effect of pretreatment with prostaglandin E2 (PGE2), verapamil, nicergoline and bromocriptine on ischemia-reperfusion injury of rat liver in vivo. ( Tilser, I, 1994)
" We investigated the effect of the calcium channel blocker verapamil on hepatic ischemia/reperfusion injury in normal rats and rats sensitized to oxidative injury by chemical depletion of the endogenous antioxidant glutathione."7.68Effect of verapamil on hepatic ischemia/reperfusion injury. ( Hinder, RA; Lamprechts, H; Oosthuizen, MM; Stein, HJ, 1993)
"The effects of verapamil and nifedipine on cellular mechanisms of arrhythmia were examined in isolated canine Purkinje fiber-papillary muscles."7.68Effects of verapamil and nifedipine on mechanisms of arrhythmia in an in vitro model of ischemia and reperfusion. ( Ferrier, GR; Mohabir, R, 1991)
"We investigated the cytoprotective effects of verapamil, a Ca channel blocker, and of iloprost (ZK 36374), a stable prostacyclin analogue, on ischemia/reperfusion (I/R) injury in Wistar albino rat kidneys that were subjected to 60 min of warm ischemia and reperfusion."7.68The cytoprotective effects of verapamil and iloprost (ZK 36374) on ischemia/reperfusion injury of kidneys. ( Aktan, AO; Döşlüoğlu, HH; Ercan, S; Okboy, N; Yahn, R; Yalçm, AS; Yeğen, C, 1993)
"Digoxin treatment produced a significant decrease in cerebral infarct size and reversal of I/R induced impairment of memory and motor incoordination."5.35Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice. ( Jaggi, AS; Kaur, S; Rehni, AK; Singh, N, 2009)
"The verapamil- pretreated group (group IV) showed statistical significantly lower values of MDA and protein carbonyl content when compared with group II and III (p < 0."5.32The effect of verapamil on the prevention of ischemia/reperfusion injury in the experimental retroperitoneoscopic donor nephrectomy model. ( Demirbas, M; Dincel, C; Guler, C; Köken, T; Polat, C; Samli, M, 2004)
" Thirty-nine patients were injected with Verapamil through the mesenteric vein before Pringle's maneuver to alleviate hepatic ischemia-reperfusion injury, while 47 patients were not."5.14Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"Male SD rats were randomly divided into five groups: false operation (group A); rats subjected to 50%hepatectomy and 45 min of hepatic ischemia (group B); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with isoglycyrrhizinate (group C); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with verapamil (group D); rats subjected to 50% hepatectomy and 45 min of hepatic ischemia, and treated with isoglycyrrhizinate and verapamil (group E)."3.81[Protective effect of magnesium isoglycyrrhizinate combinated with verapamil on liver ischemia-reperfusion injury after semi-hepatectomy in rats]. ( Chen, Z; Hu, C; Huang, C; Li, W; Qin, F; Shen, S; Tan, G, 2015)
" We evaluated postoperative outcome of patients subjected to standard ANL that received 10 mg of Verapamil immediately before declamping renal artery, due to prevention of reperfusion injury."3.74Using verapamil as protective factor in renal ischemia reperfusion injury during anatrophic nephrolithotomy. ( Aganović, D; Hadziosmanović, O; Kulovac, B; Prcić, A, 2007)
"To observe the protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils."3.74[Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils]. ( Ding, N; Wang, DF; Wang, F; Xiao, H, 2007)
" This retrospective study investigates the efficacy of therapy with intracoronary verapamil to terminate reperfusion-induced ventricular tachyarrhythmias in patients with acute myocardial infarction (AMI)."3.72Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction. ( Dote, K; Habara, S; Hasegawa, D; Kato, M; Sasaki, S; Takemoto, H, 2004)
" The purpose of this study was to investigate the effects of verapamil and a tocopherol on reperfusion injury in the canine small bowel autotransplantation model."3.72The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion. ( Kilinç, K; Ozdemir, A; Ozenç, A; Yağmurdur, MC, 2003)
"In this prospective controlled study, the aim was to examine the effects of vitamin C, mannitol and verapamil on adnexial ischaemia-reperfusion injury in the rat ovary."3.71Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil. ( Apan, A; Kisa, U; Sağsöz, N, 2002)
"We studied the effect of verapamil on intestinal ischemia and reperfusion (I/R) injury."3.70Beneficial effects of verapamil on intestinal ischemia and reperfusion injury: pretreatment versus postischemic treatment. ( Fujii, Y; Kataoka, M; Kato, T; Kimura, M; Kuwabara, Y; Narita, K; Okahira, T; Sato, A, 1998)
"We investigated the effects of the calcium-channel blocker verapamil hydrochloride on the production of cytokine-induced neutrophil chemoattractant (CINC) following reperfusion injury in rat liver."3.70Calcium-channel blocker attenuates Kupffer cell production of cytokine-induced neutrophil chemoattractant following ischemia-reperfusion in rat liver. ( Akizuki, E; Goto, M; Ishihara, K; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Yamada, S; Yamaguchi, Y, 2000)
"Using the model of the isolated perfused rat liver, we investigated the influence of the two pharmacologically different calcium channel blockers, verapamil and flunarizine, on changes of ion homeostasis, liver weights, pH deviations and enzyme activities during warm ischemia (37 degrees C) and reperfusion."3.69Verapamil and flunarizine protect the isolated perfused rat liver against warm ischemia and reperfusion injury. ( Bloechle, C; Broelsch, CE; Haller, G; Konrad, T; Kusterer, K; Usadel, KH, 1995)
" Therefore the effect of pretreatment by nicergoline and bromocriptine was established in ischemia-reperfusion injury of rat liver."3.69The effect of pretreatment with prostaglandin E2 (PGE2), verapamil, nicergoline and bromocriptine on ischemia-reperfusion injury of rat liver in vivo. ( Tilser, I, 1994)
"Levemopamil, a novel calcium channel blocker with antagonistic action on serotonin S2-receptors has been reported to be a promising compound for therapy in cerebral ischemia."3.69Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats. ( Croul, S; Gomi, S; Greenberg, JH; Reivich, M, 1995)
"The purpose of this study was to investigate the protective effects of the calcium channel blocker verapamil on warm ischemia-reperfusion injury to the liver using a rat model."3.69Protective effects of the calcium channel blocker verapamil on hepatic function following warm ischemia. ( Garcia, R; Helton, WS; Karwinski, W, 1996)
"We investigated the cytoprotective effects of verapamil, a Ca channel blocker, and of iloprost (ZK 36374), a stable prostacyclin analogue, on ischemia/reperfusion (I/R) injury in Wistar albino rat kidneys that were subjected to 60 min of warm ischemia and reperfusion."3.68The cytoprotective effects of verapamil and iloprost (ZK 36374) on ischemia/reperfusion injury of kidneys. ( Aktan, AO; Döşlüoğlu, HH; Ercan, S; Okboy, N; Yahn, R; Yalçm, AS; Yeğen, C, 1993)
" We investigated the effect of the calcium channel blocker verapamil on hepatic ischemia/reperfusion injury in normal rats and rats sensitized to oxidative injury by chemical depletion of the endogenous antioxidant glutathione."3.68Effect of verapamil on hepatic ischemia/reperfusion injury. ( Hinder, RA; Lamprechts, H; Oosthuizen, MM; Stein, HJ, 1993)
"The effects of verapamil and nifedipine on cellular mechanisms of arrhythmia were examined in isolated canine Purkinje fiber-papillary muscles."3.68Effects of verapamil and nifedipine on mechanisms of arrhythmia in an in vitro model of ischemia and reperfusion. ( Ferrier, GR; Mohabir, R, 1991)
"Verapamil has been hypothesized to mitigate ischemia reperfusion injury (IRI) to the allograft."2.90Does intra-operative verapamil administration in kidney transplantation improve graft function. ( Bidnur, S; Caldas, M; Ghosh, S; Gupta, N; Moore, RB; Sharma, N; Todd, GT, 2019)
"In group 2, a 2-hr testicular torsion was induced, and thereafter, detorsion was done."1.56The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats. ( Davoodi, F; Hablolvarid, MH; Raisi, A; Rajabzadeh, A; Zakian, A, 2020)
"Treatment with tadalafil and verapamil decreased the MDA level in treatment groups and also observed a significant change in sperm parameters between Sham and other groups."1.48Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat. ( Ameli, M; Hashemi, MS; Moghimian, M; Shokoohi, M, 2018)
"Verapamil treatment prevented increased permeability in HT29 cells and led to an increase in IgA transport."1.40Salutary effect of calcium channel blockade following hypoxic and septic insult. ( Ali, AA; Diebel, LN; Liberati, DM; Mutchnick, S, 2014)
"Verapamil treatment reversed MEK-induced viability of kidney SP cells."1.39ABCG2 protects kidney side population cells from hypoxia/reoxygenation injury through activation of the MEK/ERK pathway. ( Gao, DK; Ge, GQ; Liu, HB; Liu, SB; Liu, WH; Sun, SR; Wang, HM; Zhang, P, 2013)
"The verapamil group was given 0."1.35Role of allopurinol, verapamil, dexamethasone and trifluoperazine as prophylactic agents in intestinal ischemia-reperfusion. ( Devecí, E, 2008)
"Digoxin treatment produced a significant decrease in cerebral infarct size and reversal of I/R induced impairment of memory and motor incoordination."1.35Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice. ( Jaggi, AS; Kaur, S; Rehni, AK; Singh, N, 2009)
"The verapamil- pretreated group (group IV) showed statistical significantly lower values of MDA and protein carbonyl content when compared with group II and III (p < 0."1.32The effect of verapamil on the prevention of ischemia/reperfusion injury in the experimental retroperitoneoscopic donor nephrectomy model. ( Demirbas, M; Dincel, C; Guler, C; Köken, T; Polat, C; Samli, M, 2004)
"The verapamil-treated group showed lower values of MDA (P < 0."1.32Effects of carbon dioxide pneumoretroperitoneum on free radical formation in remote organs and use of verapamil as an antioxidant. ( Aksoy, Y; Demirbas, M; Dincel, C; Ellidokuz, E; Guler, C; Kilinç, A; Samli, M, 2004)
"Reperfusion injury is a phenomenon complicating microvascular reconstruction."1.29Limiting impairment of muscle function following ischemia and reperfusion in rabbits. ( Huang, L; Klitzman, B; Panza, W; Serafin, D; Zavitsanos, G, 1996)
"Acute renal failure following hemorrhagic shock was studied in awake rats."1.28Acute renal failure following hemorrhagic shock: protective and aggravating factors. ( Rocha, AS; Seguro, AC; Yu, L, 1992)
"Pretreatment with verapamil (10 micrograms/kg/min delivered intravenously) prevented the fall in GFR (320 +/- 70 microliters/min 100 g), as did pretreatment with nitrendipine, 1 micrograms/kg/min (460 +/- 90 microliters/min/100 g)."1.28Evidence that calcium channel blockade prevents cyclosporine-induced exacerbation of renal ischemic injury. ( Bia, MJ; Tyler, K, 1991)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.39)18.7374
1990's36 (50.00)18.2507
2000's22 (30.56)29.6817
2010's10 (13.89)24.3611
2020's3 (4.17)2.80

Authors

AuthorsStudies
Davoodi, F2
Raisi, A2
Rajabzadeh, A2
Hablolvarid, MH2
Zakian, A2
Jangholi, E1
Sharifi, ZN1
Hoseinian, M1
Zarrindast, MR1
Rahimi, HR1
Mowla, A1
Aryan, H1
Javidi, MA1
Parsa, Y1
Ghaffarpasand, F1
Yadollah-Damavandi, S1
Arani, HZ1
Shahi, F1
Movassaghi, S1
Taheri, S1
Khezri, A1
Ahmadvand, H1
Echeverri, J1
Goldaracena, N1
Kaths, JM1
Linares, I1
Roizales, R1
Kollmann, D1
Hamar, M1
Urbanellis, P1
Ganesh, S1
Adeyi, OA1
Tazari, M1
Selzner, M1
Selzner, N1
Ameli, M1
Hashemi, MS1
Moghimian, M1
Shokoohi, M1
Saber, M1
Eimani, H1
Soleimani Mehranjani, M1
Shahverdi, A1
Momeni, HR1
Fathi, R1
Tavana, S1
Gupta, N1
Caldas, M1
Sharma, N1
Bidnur, S1
Ghosh, S1
Todd, GT1
Moore, RB1
Ali, AA1
Mutchnick, S1
Liberati, DM1
Diebel, LN1
Jiang, Z1
Hu, P1
Liu, J1
Wang, D1
Jin, L1
Hong, C1
Li, W1
Chen, Z1
Shen, S1
Hu, C1
Tan, G1
Huang, C1
Qin, F1
Devecí, E1
Kovacs, K1
Hanto, K1
Bognar, Z1
Tapodi, A1
Bognar, E1
Kiss, GN1
Szabo, A1
Rappai, G1
Kiss, T1
Sumegi, B1
Gallyas, F1
Kaur, S1
Rehni, AK1
Singh, N1
Jaggi, AS1
Xia, F1
Wang, S1
Chen, M1
Wang, X1
Feng, X1
Dong, J1
Tomita, M2
Takizawa, Y2
Kishimoto, H2
Hayashi, M2
Gao, DJ1
Xuan, XJ1
Wang, YJ1
Sun, BG1
Wang, JX1
Fang, QJ1
Wang, YF1
Wang, RX1
Wu, ZJ1
He, RL1
Peng, XP1
Rinker, B1
Fink, BF1
Stoker, AR1
Milan, ME1
Nelson, PT1
Liu, WH1
Liu, HB1
Gao, DK1
Ge, GQ1
Zhang, P1
Sun, SR1
Wang, HM1
Liu, SB1
Fang, W1
Lv, P1
Geng, X1
Shang, E1
Yang, Q1
Sha, L1
Li, Y1
Sağsöz, N1
Kisa, U1
Apan, A1
Yağmurdur, MC1
Ozdemir, A1
Ozenç, A1
Kilinç, K2
Guler, C2
Samli, M2
Aksoy, Y1
Demirbas, M2
Kilinç, A1
Ellidokuz, E1
Dincel, C2
Kato, M1
Dote, K1
Sasaki, S1
Takemoto, H1
Habara, S1
Hasegawa, D1
Köken, T1
Polat, C1
Yasuda, Y1
Maruyama, T1
Nakamura, H1
Arita, T1
Ueda, N1
Harada, M1
Ding, N1
Wang, F1
Xiao, H1
Wang, DF1
Aganović, D1
Kulovac, B1
Prcić, A1
Hadziosmanović, O1
Kaplan, N1
Yagmurdur, H1
Baltaci, B1
Tezel, S1
Takayama, J1
Takaoka, M2
Yamamoto, S1
Nohara, A1
Ohkita, M1
Matsumura, Y3
Toronyi, E2
Yeğen, C2
Aktan, AO2
Büyükgebiz, O1
Haklar, G1
Yalçin, AS1
Yalin, R1
Ercan, S2
Konrad, T1
Bloechle, C1
Haller, G1
Broelsch, CE1
Usadel, KH1
Kusterer, K1
Döşlüoğlu, HH1
Okboy, N1
Yalçm, AS1
Yahn, R1
Tilser, I1
Sorrenti, V1
Di Giacomo, C1
Renis, M1
Russo, A1
La Delfa, C1
Perez-Polo, JR1
Vanella, A1
Uchida, M1
Takemoto, Y1
Nagasue, N1
Dhar, DK1
Kohno, H1
Nakamura, T1
Bamberger, MH1
Qien, L1
Foschi, D1
Castoldi, L1
Lesma, A1
Musazzi, M1
Benevento, A1
Trabucchi, E1
Bertuglia, S1
Colantuoni, A1
Intaglietta, M1
Shirakura, R1
Kamiike, W1
Matsumura, A1
Miyagawa, S1
Fukushima, N1
Hatanaka, N1
Chang, JC1
Shimizu, S1
Sueki, H1
Amemiya, A1
Bretan, P1
Paul, G1
Sharma, J1
Stein, HJ1
Oosthuizen, MM1
Hinder, RA1
Lamprechts, H1
Gomi, S1
Greenberg, JH1
Croul, S1
Reivich, M1
Zavitsanos, G1
Huang, L1
Panza, W1
Serafin, D1
Klitzman, B1
Karwinski, W1
Garcia, R1
Helton, WS1
Shaheen, AA1
Abd-el-Fattah, AA1
Seif-el-Nasr, M1
al-Dohayan, AD1
al-Tuwaijri, AS1
Kimura, M1
Kataoka, M1
Kuwabara, Y1
Sato, A1
Kato, T1
Narita, K1
Okahira, T1
Fujii, Y1
Bagirov, AM1
Kanaya, N1
Nakayama, M1
Kobayashi, I1
Fujita, S1
Namiki, A1
Nishiura, M1
Deguchi, S1
Hashimoto, N1
Ogawa, T1
Seo, R1
Hamar, J1
Perner, F1
Szende, B1
Liang, J1
Yamaguchi, Y1
Matsumura, F1
Goto, M1
Akizuki, E1
Matsuda, T1
Okabe, K1
Ohshiro, H1
Ishihara, K1
Yamada, S1
Mori, K1
Ogawa, M1
Yamashita, J1
Itoh, M1
Kuro, T1
Kobayashi, Y1
Ogata, M1
Oliveira, CP1
Lopasso, FP1
Laurindo, FR1
Leitão, RM1
Laudanna, AA1
Ishii, K2
Arima, T1
Suita, S2
Pickford, MA2
Manek, S1
Price, AB1
Green, CJ2
Yu, L1
Seguro, AC1
Rocha, AS1
Mohabir, R1
Ferrier, GR1
Wickersham, NE1
Johnson, JJ1
Meyrick, BO1
Gilroy, RJ1
Loyd, JE1
Bia, MJ1
Tyler, K1
Nauta, RJ1
Tsimoyiannis, E1
Uribe, M1
Walsh, DB1
Miller, D1
Butterfield, A1
Matsushima, S1
Shoji, T1
Montefusco, CM1
Veith, FJ1
Shinohara, M1
Kayashima, K1
Konomi, K1
Sumimoto, H1
Sarathchandra, P1
Fryer, PR1
Griffiths, EJ1
Brunt, RV1
Yokomise, H1
Ueno, T1
Yamazaki, F1
Keshavjee, S1
Slutsky, A1
Patterson, G1
Hornsey, S1
Myers, R1
Jenkinson, T1
Sobh, MA1
Shehab el-Din, AB1
Moustafa, FE1
el-Far, MA1
Hussein, ME1
Gad, HM1
Ghoneim, MA1

Reviews

1 review available for verapamil and Reperfusion Injury

ArticleYear
[Role of apoptosis in the kidney after reperfusion].
    Orvosi hetilap, 2008, Feb-17, Volume: 149, Issue:7

    Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Disease Models, Animal; Fendiline; Humans; K

2008

Trials

3 trials available for verapamil and Reperfusion Injury

ArticleYear
Does intra-operative verapamil administration in kidney transplantation improve graft function.
    Clinical transplantation, 2019, Volume: 33, Issue:8

    Topics: Brain Death; Calcium Channel Blockers; Cold Ischemia; Delayed Graft Function; Female; Follow-Up Stud

2019
Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma.
    Langenbeck's archives of surgery, 2009, Volume: 394, Issue:6

    Topics: Adult; Aged; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cohort Studies; Drug Administratio

2009
A prospective randomized study of the protective effect of verapamil on ischemic renal injury in renal allotransplants.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 2

    Topics: Adult; Clinical Trials as Topic; Humans; Kidney Transplantation; Kidney Tubules, Proximal; Prospecti

1989

Other Studies

68 other studies available for verapamil and Reperfusion Injury

ArticleYear
The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats.
    Andrologia, 2020, Volume: 52, Issue:2

    Topics: Animals; Anticoagulants; Calcium Channel Blockers; Drug Evaluation, Preclinical; Drug Therapy, Combi

2020
Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Survival; Cytochrom

2020
Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats.
    Andrologia, 2021, Volume: 53, Issue:6

    Topics: Animals; Humans; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury; Salvia miltiorrhiza;

2021
Comparison of BQ123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion.
    Transplantation, 2018, Volume: 102, Issue:4

    Topics: Animals; Apoptosis; Calcium Channel Blockers; Endothelin Receptor Antagonists; Epoprostenol; Hepatic

2018
Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat.
    Andrologia, 2018, Volume: 50, Issue:8

    Topics: Animals; Drug Evaluation, Preclinical; Male; Oxidative Stress; Random Allocation; Rats, Wistar; Repe

2018
The effect of Verapamil on ischaemia/reperfusion injury in mouse ovarian tissue transplantation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Animals; Apoptosis; Calcium Channel Blockers; Female; Malondialdehyde; Mice; Ovary; Reperfusion Inju

2018
Salutary effect of calcium channel blockade following hypoxic and septic insult.
    The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:1

    Topics: Actins; Calcium Channel Blockers; Capillary Permeability; Cytoskeleton; Dextrans; Enzyme-Linked Immu

2014
[Effect of verapamil and nitroglycerin on transplanted lung function in canines].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2014, Volume: 39, Issue:8

    Topics: Animals; Blood Gas Analysis; Dogs; Hemodynamics; Lung; Lung Transplantation; Nitroglycerin; Organ Pr

2014
[Protective effect of magnesium isoglycyrrhizinate combinated with verapamil on liver ischemia-reperfusion injury after semi-hepatectomy in rats].
    Zhonghua yi xue za zhi, 2015, Oct-13, Volume: 95, Issue:38

    Topics: Animals; beta Catenin; Caspase 3; Hepatectomy; Hepatocytes; Ischemia; Liver; Liver Regeneration; Mal

2015
Role of allopurinol, verapamil, dexamethasone and trifluoperazine as prophylactic agents in intestinal ischemia-reperfusion.
    Analytical and quantitative cytology and histology, 2008, Volume: 30, Issue:2

    Topics: Allopurinol; Animals; Dexamethasone; Intestine, Small; Male; Rats; Rats, Wistar; Reperfusion Injury;

2008
Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers.
    Molecular and cellular biochemistry, 2009, Volume: 321, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Animals; Benzimidazoles; Calcium Channel Blockers; Cardiotonic Agents;

2009
Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2009, Volume: 129, Issue:4

    Topics: Amiloride; Animals; Brain; Brain Ischemia; Calcium; Calcium Signaling; Digoxin; Male; Memory; Mice;

2009
Effect of intestinal ischaemia/reperfusion on P-glycoprotein-mediated ileal excretion of rhodamine 123 in the rat.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:10

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Gene Expression; Ileum; Male; Memb

2009
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
    Drug metabolism and pharmacokinetics, 2009, Volume: 24, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosp

2009
[Verapamil and hypothermia protect spermatogenesis of torsioned testes in rats].
    Zhonghua nan ke xue = National journal of andrology, 2009, Volume: 15, Issue:9

    Topics: Animals; Apoptosis; Hypothermia, Induced; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sper

2009
[The effect of different dose of verapamil and propranolol in kalium cardioplegia on the function of immature rat heart].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2008, Volume: 24, Issue:2

    Topics: Animals; Cardioplegic Solutions; Female; Heart; In Vitro Techniques; Male; Myocardium; Propranolol;

2008
Calcium channel blockers reduce the effects of cigarette smoking on peripheral nerve ischemia/reperfusion injury.
    Annals of plastic surgery, 2013, Volume: 70, Issue:2

    Topics: Animals; Calcium Channel Blockers; Cotinine; Disease Models, Animal; Male; Nifedipine; Rats; Rats, W

2013
ABCG2 protects kidney side population cells from hypoxia/reoxygenation injury through activation of the MEK/ERK pathway.
    Cell transplantation, 2013, Volume: 22, Issue:10

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters;

2013
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation.
    Neurochemistry international, 2013, Volume: 62, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bloo

2013
Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil.
    Human reproduction (Oxford, England), 2002, Volume: 17, Issue:11

    Topics: Animals; Antioxidants; Ascorbic Acid; Calcium Channel Blockers; Female; Free Radical Scavengers; Isc

2002
The effects of alpha - tocopherol and verapamil on mucosal functions after gut ischemia / reperfusion.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2003, Volume: 14, Issue:1

    Topics: alpha-Tocopherol; Analysis of Variance; Animals; Disease Models, Animal; Dogs; Hypertonic Solutions;

2003
Effects of carbon dioxide pneumoretroperitoneum on free radical formation in remote organs and use of verapamil as an antioxidant.
    Journal of endourology, 2004, Volume: 18, Issue:3

    Topics: Animals; Antioxidants; Carbon Dioxide; Free Radicals; Gases; Male; Models, Animal; Oxidative Stress;

2004
Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction.
    Chest, 2004, Volume: 126, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Calcium Chan

2004
The effect of verapamil on the prevention of ischemia/reperfusion injury in the experimental retroperitoneoscopic donor nephrectomy model.
    Surgical endoscopy, 2004, Volume: 18, Issue:8

    Topics: Animals; Glutathione; Laparoscopy; Male; Malondialdehyde; Models, Animal; Nephrectomy; Oxidative Str

2004
Pathophysiological basis for monitoring of whole heart conductance by 2-lead system.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:4

    Topics: Animals; Calcium; Electric Countershock; Electrodes; Heart Atria; Heart Conduction System; Heptanol;

2006
[Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:7

    Topics: Animals; Brain; Brain Ischemia; Endothelins; Gerbillinae; Glutathione; Malondialdehyde; Receptors, C

2007
Using verapamil as protective factor in renal ischemia reperfusion injury during anatrophic nephrolithotomy.
    Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:3

    Topics: Adult; Female; Humans; Kidney; Kidney Calculi; Male; Middle Aged; Nephrostomy, Percutaneous; Renal A

2007
The protective effects of intravenous anesthetics and verapamil in gut ischemia/reperfusion-induced liver injury.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:5

    Topics: Anesthetics, Intravenous; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination

2007
Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: Acute Disease; Animals; Female; Hydroxamic Acids; Ischemia; Kidney; Male; Metalloendopeptidases; Pro

2008
Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1994, Volume: 26, Issue:2

    Topics: Animals; Dinoprostone; Endothelins; Female; Iloprost; Intestinal Mucosa; Leukotriene C4; Malondialde

1994
Verapamil and flunarizine protect the isolated perfused rat liver against warm ischemia and reperfusion injury.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1995, Volume: 195, Issue:2

    Topics: Animals; Calcium; Female; Flunarizine; Glutamate Dehydrogenase; Homeostasis; Hot Temperature; Hydrog

1995
The cytoprotective effects of verapamil and iloprost (ZK 36374) on ischemia/reperfusion injury of kidneys.
    Transplant international : official journal of the European Society for Organ Transplantation, 1993, Volume: 6, Issue:3

    Topics: Animals; Creatinine; Glutathione; Iloprost; Ischemia; Kidney; Male; Malondialdehyde; Rats; Rats, Wis

1993
The effect of pretreatment with prostaglandin E2 (PGE2), verapamil, nicergoline and bromocriptine on ischemia-reperfusion injury of rat liver in vivo.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1994, Volume: 37, Issue:1

    Topics: Animals; Bromocriptine; Dinoprostone; Female; Liver; Nicergoline; Rats; Rats, Wistar; Reperfusion In

1994
Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
    Drugs under experimental and clinical research, 1994, Volume: 20, Issue:5

    Topics: Allopurinol; Animals; Antioxidants; Brain Ischemia; Deferoxamine; Diltiazem; Lipid Peroxidation; Mal

1994
Effect of verapamil on hepatic reperfusion injury after prolonged ischemia in pigs.
    Journal of hepatology, 1994, Volume: 21, Issue:2

    Topics: Animals; Aspartate Aminotransferases; Calcium; Calcium Channel Blockers; Female; Liver; Male; Oxygen

1994
Molecular response to calcium channel blockers expressed during reperfusion following acute renal ischemia.
    Annals of the New York Academy of Sciences, 1994, Jun-17, Volume: 723

    Topics: Animals; Clusterin; Creatinine; Gene Expression; Glycoproteins; Kidney; Male; Molecular Chaperones;

1994
Effects of ischaemia and reperfusion on liver regeneration in rats.
    The European journal of surgery = Acta chirurgica, 1993, Volume: 159, Issue:8

    Topics: Allopurinol; Animals; Female; Free Radicals; Hepatectomy; Ischemia; Lipid Peroxidation; Lipid Peroxi

1993
Effect of leukocyte adhesion and microvascular permeability on capillary perfusion during ischemia-reperfusion injury in hamster cheek pouch.
    International journal of microcirculation, clinical and experimental, 1993, Volume: 13, Issue:1

    Topics: Adenosine; Allopurinol; Animals; Capillary Permeability; Cell Adhesion; Cheek; Cricetinae; Diltiazem

1993
Multiorgan procurement from non-heart-beating donors by use of Osaka University cocktail, Osaka rinse solution, and the portable cardiopulmonary bypass machine.
    Transplantation proceedings, 1993, Volume: 25, Issue:6

    Topics: Animals; Cardiopulmonary Bypass; Dogs; Drug Combinations; Epoprostenol; Heart Transplantation; Kidne

1993
Improved renal preservation with PB-3 flush solution during 72 hours cold storage: demonstration of a salutary effect on isolated mitochondrial respiration.
    Transplantation proceedings, 1993, Volume: 25, Issue:6

    Topics: Allopurinol; Animals; Cold Temperature; Dogs; Kidney; Kidney Transplantation; Kinetics; Mannitol; Mi

1993
Effect of verapamil on hepatic ischemia/reperfusion injury.
    American journal of surgery, 1993, Volume: 165, Issue:1

    Topics: Alanine Transaminase; Animals; Glutathione; Lipid Peroxidation; Liver; Male; Maleates; Rats; Rats, S

1993
Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats.
    Journal of the neurological sciences, 1995, Volume: 130, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebral Infarcti

1995
Limiting impairment of muscle function following ischemia and reperfusion in rabbits.
    Journal of reconstructive microsurgery, 1996, Volume: 12, Issue:3

    Topics: Animals; Calcium Channel Blockers; Deferoxamine; Dimethyl Sulfoxide; Forelimb; Free Radical Scavenge

1996
Protective effects of the calcium channel blocker verapamil on hepatic function following warm ischemia.
    The Journal of surgical research, 1996, Volume: 64, Issue:2

    Topics: Alanine Transaminase; Animals; Bile; Calcium Channel Blockers; Glutathione; Hot Temperature; L-Lacta

1996
Influence of verapamil on the efficacy of vitamin E in preventing the ischemia-reperfusion-induced biochemical dearrangement in cerebral cortex of rat.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:7

    Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; L-Lactate Dehydrogenase; Lipid Peroxidation; Mal

1996
The potential synergistic effect of calcium channel blockers and alpha-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:11

    Topics: Administration, Oral; Animals; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Dose-Res

1996
Beneficial effects of verapamil on intestinal ischemia and reperfusion injury: pretreatment versus postischemic treatment.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1998, Volume: 30, Issue:3

    Topics: Animals; Edema; Intestinal Diseases; Intestines; Ischemia; Magnetic Resonance Spectroscopy; Male; Ra

1998
[Effect of calcium antagonists on the kidney transplant damage during prolonged cold ischemia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:4

    Topics: Animals; Calcium Channel Blockers; Cold Temperature; Ischemia; Kidney; Kidney Transplantation; Lipid

1998
Effect of isoflurane on epinephrine-induced arrhythmias in ischemic-reperfused dog hearts.
    Research communications in molecular pathology and pharmacology, 1998, Volume: 100, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Calcium Channel Blo

1998
Protective effect of FK409, a spontaneous nitric oxide releaser, on ischemic acute renal failure in rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Kidney Medu

1998
Prevention of apoptosis reperfusion renal injury by calcium channel blockers.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1999, Volume: 51, Issue:3

    Topics: Animals; Apoptosis; Bepridil; Calcium Channel Blockers; Fendiline; Kidney; Kidney Tubules; Male; Nif

1999
Calcium-channel blocker attenuates Kupffer cell production of cytokine-induced neutrophil chemoattractant following ischemia-reperfusion in rat liver.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:1

    Topics: Animals; Blotting, Northern; Calcium Channel Blockers; Chemokines, CXC; Chemotactic Factors; Growth

2000
Pre- or post-ischemic treatment with a novel Na+/Ca2+ exchange inhibitor, KB-R7943, shows renal protective effects in rats with ischemic acute renal failure.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Calcium Channe

2001
Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil.
    Transplantation proceedings, 2001, Volume: 33, Issue:6

    Topics: Animals; Calcium Channel Blockers; Liver; Liver Circulation; Luminescent Measurements; Oxidative Str

2001
Verapamil attenuates postischemic oxidative injury in the rat liver.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1992, Volume: 192, Issue:3

    Topics: Animals; Body Water; Infusions, Intravenous; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver Dise

1992
The pathology of rat lung isografts following 48 or 72-hour cold storage and subsequent reperfusion in vivo for up to 1 month.
    International journal of experimental pathology, 1992, Volume: 73, Issue:5

    Topics: Animals; Cryopreservation; Epoprostenol; Hemorrhage; Lung; Lung Transplantation; Male; Organ Preserv

1992
Acute renal failure following hemorrhagic shock: protective and aggravating factors.
    Renal failure, 1992, Volume: 14, Issue:1

    Topics: Acute Kidney Injury; Allopurinol; Animals; Calcium; Dehydration; Free Radicals; Gentamicins; Kidney;

1992
Effects of verapamil and nifedipine on mechanisms of arrhythmia in an in vitro model of ischemia and reperfusion.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Diastole; Dogs; Electrophysiology; Heart Co

1991
Lung ischemia-reperfusion injury in awake sheep: protection with verapamil.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:4

    Topics: Animals; Blood Gas Analysis; Blood Proteins; Cardiac Output; Eicosanoids; Enzyme-Linked Immunosorben

1991
Evidence that calcium channel blockade prevents cyclosporine-induced exacerbation of renal ischemic injury.
    Transplantation, 1991, Volume: 51, Issue:2

    Topics: Animals; Blood Pressure; Calcium Channels; Cyclosporins; Diuresis; Glomerular Filtration Rate; Kidne

1991
The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury.
    Annals of surgery, 1991, Volume: 213, Issue:2

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Calcium; L-Iditol

1991
The effect of verapamil on ex-vivo rat lung preservation.
    Nihon Ika Daigaku zasshi, 1991, Volume: 58, Issue:2

    Topics: Animals; In Vitro Techniques; Lung Transplantation; Male; Organ Preservation; Organ Size; Rats; Rats

1991
Protective effects of verapamil on ischemia-induced hepatic damage in the rat.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1990, Volume: 22, Issue:5

    Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Ischemia; Liver; Male; Rats; Rats, Inbred Strain

1990
Effect of verapamil on conversion of xanthine dehydrogenase to oxidase in ischemic rat liver.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1990, Volume: 190, Issue:6

    Topics: Animals; Calcium; Free Radicals; In Vitro Techniques; Ischemia; Liver; Male; Oxygen; Rats; Rats, Inb

1990
Ultrastructural changes in rat lungs after 48 h cold storage with and without reperfusion.
    International journal of experimental pathology, 1990, Volume: 71, Issue:4

    Topics: Allopurinol; Animals; Basement Membrane; Cryopreservation; Deferoxamine; Endothelium, Vascular; Epop

1990
The effect of calcium antagonists on the activities of lipid metabolizing enzymes in the isolated ischaemically perfused and reperfused rat heart.
    Journal of molecular and cellular cardiology, 1990, Volume: 22, Issue:3

    Topics: Acyltransferases; Animals; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Glycerol-

1990
The effect and optimal time of administration of verapamil on lung preservation.
    Transplantation, 1990, Volume: 49, Issue:6

    Topics: Animals; Drug Administration Schedule; Lung; Rabbits; Reperfusion Injury; Respiratory Function Tests

1990
The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs.
    International journal of radiation oncology, biology, physics, 1990, Volume: 18, Issue:6

    Topics: Animals; Deferoxamine; Dipyridamole; Male; Necrosis; Radiation Injuries, Experimental; Rats; Reperfu

1990