verapamil has been researched along with Poisoning in 34 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effect of levosimendan on cardiac output (CO), blood pressure (BP), and heart rate (HR) in a rodent model of severe verapamil poisoning." | 7.74 | Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. ( Graudins, A; Najafi, J; Rur-SC, MP, 2008) |
| "In an animal model of verapamil-induced shock, endogenous AVP levels increased nearly 40-fold compared with baseline levels." | 7.72 | Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study. ( Bond, GR; Johnson, SB; Sztajnkrycer, MD; Weaver, AL, 2004) |
| "To present three cases of slow-release verapamil poisoning that demonstrate the prolonged absorption of the drug and the role of polyethylene glycol and high-dose calcium in management." | 7.68 | Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium. ( Buckley, N; Dawson, AH; Howarth, D; Whyte, IM, 1993) |
| "To assess the effect of levosimendan on cardiac output (CO), blood pressure (BP), and heart rate (HR) in a rodent model of severe verapamil poisoning." | 3.74 | Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. ( Graudins, A; Najafi, J; Rur-SC, MP, 2008) |
| " We performed a randomized, controlled, blinded trial in a porcine model to study the effects of vasopressin infusion on mean arterial pressure after verapamil poisoning." | 3.73 | Vasopressin treatment of verapamil toxicity in the porcine model. ( Barry, JD; Cantrell, L; Clark, RF; Durkovich, D; Offerman, S; Richardson, W; Tanen, DA; Tong, T; Williams, S, 2005) |
| "In an animal model of verapamil-induced shock, endogenous AVP levels increased nearly 40-fold compared with baseline levels." | 3.72 | Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study. ( Bond, GR; Johnson, SB; Sztajnkrycer, MD; Weaver, AL, 2004) |
| "To present three cases of slow-release verapamil poisoning that demonstrate the prolonged absorption of the drug and the role of polyethylene glycol and high-dose calcium in management." | 3.68 | Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium. ( Buckley, N; Dawson, AH; Howarth, D; Whyte, IM, 1993) |
| "This review aims to identify recent literature on the use of ILE in humans as an antidote and to familiarize emergency providers with the indications, availability, dosing recommendations, and adverse reactions associated with ILE use." | 2.52 | Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. ( Cao, D; Foran, M; Heard, K; Koyfman, A, 2015) |
| " Although some volunteer studies have shown substantial decreases in the bioavailability of ingested drugs, no controlled clinical trials have been performed and there is no conclusive evidence that WBI improves the outcome of the poisoned patient." | 2.40 | Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. ( Tenenbein, M, 1997) |
| " Although specific recommendations for calcium dosing in the overdose situation have not been rigorously studied, maintenance of a normal serum ionized calcium concentration is suggested." | 2.38 | Verapamil overdose: case report and review of the literature. ( Crain, JL; Edwards, TD; Stiller, RA; Watling, SM, 1992) |
| " IFE therapy is being recommended by US PCCs; protocols and dosing regimens are nearly uniform." | 1.39 | Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning? ( Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M, 2013) |
| "Verapamil is a lipid-soluble calcium channel blocker with significant mortality in overdose." | 1.33 | Intralipid prolongs survival in a rat model of verapamil toxicity. ( Cave, G; Harvey, M; Nicholson, T; Tebbutt, S, 2006) |
| "Verapamil was removed out of the blood by a clearance of 29." | 1.31 | Plasmapheresis in life-threatening verapamil intoxication. ( Keuchel, M; Kuhlmann, U; Lange, H; Müller, T; Schoenemann, H, 2000) |
| " The decline in plasma verapamil and norverapamil concentrations followed first-order kinetics, and the half-life of verapamil was 7." | 1.30 | Pharmacokinetics of verapamil in overdose. ( Kivistö, KT; Neuvonen, PJ; Tarssanen, L, 1997) |
| "Verapamil toxicity was produced in all animals following an average dose of 1." | 1.29 | Hemodynamic effects of 3,4-diaminopyridine in a swine model of verapamil toxicity. ( Martin, TG; Menegazzi, JJ; Plewa, MC; Seaberg, DC; Wolfson, AB, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 17 (50.00) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Christian, MR | 1 |
| Pallasch, EM | 1 |
| Wahl, M | 1 |
| Mycyk, MB | 1 |
| Gómez Peñalver, EM | 1 |
| Gamo de Maeyer, A | 1 |
| Portilla Blanco, RR | 1 |
| Pérez Márquez, M | 1 |
| Charpentier, C | 1 |
| Flandrois, M | 1 |
| Labombarda, F | 1 |
| Maragnes, P | 1 |
| Jokic, M | 1 |
| Villedieu, F | 1 |
| Cao, D | 1 |
| Heard, K | 1 |
| Foran, M | 1 |
| Koyfman, A | 1 |
| Sami Karti, S | 1 |
| Ulusoy, H | 1 |
| Yandi, M | 1 |
| Gündüz, A | 1 |
| Koşucu, M | 1 |
| Erol, K | 1 |
| Ratip, S | 1 |
| Link, A | 1 |
| Hammer, B | 1 |
| Weisgerber, K | 1 |
| Böhm, M | 1 |
| Sztajnkrycer, MD | 1 |
| Bond, GR | 1 |
| Johnson, SB | 1 |
| Weaver, AL | 1 |
| Tebbutt, S | 1 |
| Harvey, M | 1 |
| Nicholson, T | 1 |
| Cave, G | 1 |
| Patel, NP | 1 |
| Pugh, ME | 1 |
| Goldberg, S | 1 |
| Eiger, G | 1 |
| Fiszer, M | 1 |
| Kołaciński, Z | 1 |
| Rechciński, T | 1 |
| Graudins, A | 1 |
| Najafi, J | 1 |
| Rur-SC, MP | 1 |
| Barry, JD | 1 |
| Durkovich, D | 1 |
| Cantrell, L | 1 |
| Richardson, W | 1 |
| Tong, T | 1 |
| Offerman, S | 1 |
| Clark, RF | 1 |
| Tanen, DA | 1 |
| Williams, S | 1 |
| Johansen, KK | 1 |
| Belhage, B | 1 |
| Duraković, Z | 1 |
| Gjurasin, M | 1 |
| Gasparović, V | 1 |
| Ivanović, D | 1 |
| Plavsić, F | 1 |
| Kline, JA | 1 |
| Leonova, E | 1 |
| Raymond, RM | 1 |
| Whiteman, PJ | 1 |
| Lüscher, TF | 1 |
| Noll, G | 1 |
| Stürmer, T | 1 |
| Huser, B | 1 |
| Wenk, M | 1 |
| Plewa, MC | 1 |
| Martin, TG | 1 |
| Menegazzi, JJ | 1 |
| Seaberg, DC | 1 |
| Wolfson, AB | 1 |
| Daroca Pérez, R | 1 |
| Alfaro Olea, A | 1 |
| San Román Lazcano, FJ | 1 |
| Jiménez Santolaya, C | 1 |
| Guieu, R | 1 |
| Kopeyan, C | 1 |
| Rochat, H | 1 |
| Buckley, N | 1 |
| Dawson, AH | 1 |
| Howarth, D | 1 |
| Whyte, IM | 1 |
| Ulloa Santamaría, E | 1 |
| Capitan Guarnizo, R | 1 |
| Ibarra de la Rosa, I | 1 |
| Velasco Jabalquinto, MJ | 1 |
| Barcones Mingueza, F | 1 |
| Pérez Navero, JL | 1 |
| van Wanroy, JL | 1 |
| de Weerdt, O | 1 |
| Joore, JC | 1 |
| van der Hoven, B | 1 |
| van de Wiel, A | 1 |
| Kivistö, KT | 1 |
| Neuvonen, PJ | 1 |
| Tarssanen, L | 1 |
| Tenenbein, M | 1 |
| Kalman, S | 1 |
| Berg, S | 1 |
| Lisander, B | 1 |
| Evans, JS | 1 |
| Oram, MP | 1 |
| Kuhlmann, U | 1 |
| Schoenemann, H | 1 |
| Müller, T | 1 |
| Keuchel, M | 1 |
| Lange, H | 1 |
| Watling, SM | 1 |
| Crain, JL | 1 |
| Edwards, TD | 1 |
| Stiller, RA | 1 |
| Frierson, J | 1 |
| Bailly, D | 1 |
| Shultz, T | 1 |
| Sund, S | 1 |
| Dimas, A | 1 |
| Croker, JR | 1 |
| Vaile, JH | 1 |
| Rosansky, SJ | 1 |
| Rasmussen, OB | 1 |
| Bøtker, HE | 1 |
| Klitgård, NA | 1 |
| Filias, N | 1 |
| Jornod, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454] | Phase 4 | 10 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for verapamil and Poisoning
| Article | Year |
|---|---|
Intravenous lipid emulsion in the emergency department: a systematic review of recent literature.
Topics: Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Antidotes; Emer | 2015 |
Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenic Poisoning; Child; Child, Preschool; Coc | 1997 |
Verapamil overdose: case report and review of the literature.
Topics: Adolescent; Cardiac Pacing, Artificial; Charcoal; Drug Overdose; Fluid Therapy; Gastric Lavage; Hear | 1992 |
31 other studies available for verapamil and Poisoning
| Article | Year |
|---|---|
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideli | 2013 |
[Role of propofol in verapamil intoxication].
Topics: Humans; Male; Middle Aged; Poisoning; Propofol; Verapamil | 2014 |
[Verapamil intoxication: beware of the delayed effect].
Topics: Calcium Channel Blockers; Child, Preschool; Female; Humans; Poisoning; Time Factors; Verapamil | 2014 |
Non-cardiogenic pulmonary oedema in the course of verapamil intoxication.
Topics: Adult; Drug Overdose; Female; Humans; Poisoning; Pulmonary Edema; Respiration, Artificial; Suicide, | 2002 |
[Therapy of verapamil poisoning with noradrenaline and the phosphodiesterase inhibitor enoximone].
Topics: Adult; Calcium; Calcium Channel Blockers; Drug Therapy, Combination; Enoximone; Humans; Male; Norepi | 2002 |
Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Dog | 2004 |
Intralipid prolongs survival in a rat model of verapamil toxicity.
Topics: Animals; Calcium Channel Blockers; Confounding Factors, Epidemiologic; Disease Models, Animal; Dose- | 2006 |
Hyperinsulinemic euglycemia therapy for verapamil poisoning: case report.
Topics: Antidotes; Captopril; Critical Care; Drug Combinations; Female; Glyburide; Humans; Hyperinsulinism; | 2007 |
[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning].
Topics: 4-Aminopyridine; Acute Disease; Adrenergic beta-Antagonists; Adult; Antidotes; Antihypertensive Agen | 2007 |
Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity.
Topics: Animals; Antidotes; Blood Pressure; Calcium Chloride; Cardiac Output; Disease Models, Animal; Heart | 2008 |
Vasopressin treatment of verapamil toxicity in the porcine model.
Topics: Animals; Antidotes; Blood Pressure; Cardiac Output; Disease Models, Animal; Heart Rate; Longevity; M | 2005 |
[A 48-year-old woman's survival from a massive verapamil overdose].
Topics: Calcium Channel Blockers; Drug Overdose; Female; Humans; Middle Aged; Poisoning; Suicide, Attempted; | 2007 |
[Simultaneous poisoning with medigoxin, verapamil, insulin, medazepam, diazepam, butamirate, triamterene and hydrochlorothiazide].
Topics: Antitussive Agents; Diazepam; Humans; Hydrochlorothiazide; Insulin; Male; Medazepam; Medigoxin; Midd | 1983 |
Beneficial myocardial metabolic effects of insulin during verapamil toxicity in the anesthetized canine.
Topics: Anesthesia, Intravenous; Animals; Antidotes; Dogs; Drug Evaluation, Preclinical; Female; Heart; Hemo | 1995 |
Verapamil toxicity.
Topics: 4-Aminopyridine; Amifampridine; Animals; Poisoning; Swine; Verapamil | 1995 |
Calcium gluconate in severe verapamil intoxication.
Topics: Aged; Calcium Gluconate; Female; Humans; Poisoning; Verapamil | 1994 |
Hemodynamic effects of 3,4-diaminopyridine in a swine model of verapamil toxicity.
Topics: 4-Aminopyridine; Amifampridine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; F | 1994 |
[Poisoning by delayed-release verapamil in renal insufficiency patients].
Topics: Aged; Aged, 80 and over; Delayed-Action Preparations; Female; Humans; Hypertension; Poisoning; Renal | 1993 |
Utilization of aspirin, quinine and verapamil in the prevention and treatment of scorpion venom intoxication.
Topics: Animals; Aspirin; Female; gamma-Aminobutyric Acid; Lethal Dose 50; Mice; Mice, Inbred C57BL; Poisoni | 1993 |
Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium.
Topics: Adolescent; Adult; Calcium; Charcoal; Delayed-Action Preparations; Drug Overdose; Female; Gastric La | 1993 |
[Severe theophylline poisoning in an infant: management in a pediatric emergency care unit].
Topics: Bronchiolitis; Dose-Response Relationship, Drug; Electroshock; Emergency Service, Hospital; Female; | 1993 |
[Overdose of a drug with delayed action].
Topics: Adult; Calcium Channel Blockers; Critical Care; Delayed-Action Preparations; Drug Overdose; Fatal Ou | 1996 |
Pharmacokinetics of verapamil in overdose.
Topics: Adult; Calcium Channel Blockers; Drug Overdose; Female; Half-Life; Humans; Male; Middle Aged; Poison | 1997 |
Combined overdose with verapamil and atenolol: treatment with high doses of adrenergic agonists.
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Atenolol; Calcium Channel Blockers; Drug Overdose; | 1998 |
Neurological recovery after prolonged verapamil-induced cardiac arrest.
Topics: Adolescent; Calcium Channel Blockers; Female; Heart Arrest; Humans; Paroxetine; Poisoning; Selective | 1999 |
Plasmapheresis in life-threatening verapamil intoxication.
Topics: Acute Disease; Adolescent; Adult; Animals; Calcium Channel Blockers; Female; Humans; Plasmapheresis; | 2000 |
Refractory cardiogenic shock and complete heart block after unsuspected verapamil-SR and atenolol overdose.
Topics: Atenolol; Delayed-Action Preparations; Drug Overdose; Electrocardiography; Emergency Service, Hospit | 1991 |
Management of massive verapamil overdose.
Topics: Adult; Humans; Male; Poisoning; Verapamil | 1991 |
Verapamil toxicity--treatment with hemoperfusion.
Topics: Hemoperfusion; History, 17th Century; Humans; Liver; Male; Poisoning; Verapamil | 1991 |
[Verapamil poisoning. Report of a case and a review of therapeutic results].
Topics: Female; Humans; Middle Aged; Poisoning; Verapamil | 1986 |
[Cardiovascular complications of tricyclic anti-depressants. Apropos of a case of acute poisoning].
Topics: Adult; Arrhythmias, Cardiac; Bundle-Branch Block; Diazepam; Digitalis Glycosides; Electrocardiograph | 1973 |