Page last updated: 2024-10-24

verapamil and Parkinson Disease

verapamil has been researched along with Parkinson Disease in 6 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"The cause of Parkinson's disease (PD) is unknown."1.35Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease. ( Bartels, AL; Lammertsma, AA; Leenders, KL; Lubberink, M; Luurtsema, G; van Berckel, BN, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Z1
Wu, J1
Yang, X1
Cai, P1
Liu, Q1
Wang, KDG1
Kong, L1
Wang, X1
Kortekaas, R2
Leenders, KL3
van Oostrom, JC2
Vaalburg, W1
Bart, J1
Willemsen, AT2
Hendrikse, NH1
Bartels, AL2
de Jong, BM1
de Vries, R1
de Klerk, O1
Portman, A1
van Berckel, BN1
Lubberink, M1
Luurtsema, G1
Lammertsma, AA1
Sen, AP1
Boksa, P1
Quirion, R1
García-Albea, E1
Jiménez-Jiménez, FJ1
Ayuso-Peralta, L1
Cabrera-Valdivia, F1
Vaquero, A1
Tejeiro, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled Trial of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells as a Disease-modifying Therapy for Idiopathic Parkinson's Disease[NCT04506073]Phase 245 participants (Actual)Interventional2020-11-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for verapamil and Parkinson Disease

ArticleYear
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.
    Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22

    Topics: Animals; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Mice; Mice, Inbred S

2016
Blood-brain barrier dysfunction in parkinsonian midbrain in vivo.
    Annals of neurology, 2005, Volume: 57, Issue:2

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Female; Humans;

2005
Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Mapping; C

2008
Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease.
    Parkinsonism & related disorders, 2008, Volume: 14, Issue:6

    Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Calcium C

2008
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Aged; Alzheimer Disease; Autopsy; Binding Sites; Brain; Calcium; Calcium Channels; Dihydropyridines;

1993
Parkinsonism unmasked by verapamil.
    Clinical neuropharmacology, 1993, Volume: 16, Issue:3

    Topics: Antiparkinson Agents; Humans; Male; Middle Aged; Parkinson Disease; Verapamil

1993