verapamil has been researched along with Parkinson Disease in 6 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Excerpt | Relevance | Reference |
---|---|---|
"The cause of Parkinson's disease (PD) is unknown." | 1.35 | Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease. ( Bartels, AL; Lammertsma, AA; Leenders, KL; Lubberink, M; Luurtsema, G; van Berckel, BN, 2008) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (33.33) | 18.2507 |
2000's | 3 (50.00) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Wang, Z | 1 |
Wu, J | 1 |
Yang, X | 1 |
Cai, P | 1 |
Liu, Q | 1 |
Wang, KDG | 1 |
Kong, L | 1 |
Wang, X | 1 |
Kortekaas, R | 2 |
Leenders, KL | 3 |
van Oostrom, JC | 2 |
Vaalburg, W | 1 |
Bart, J | 1 |
Willemsen, AT | 2 |
Hendrikse, NH | 1 |
Bartels, AL | 2 |
de Jong, BM | 1 |
de Vries, R | 1 |
de Klerk, O | 1 |
Portman, A | 1 |
van Berckel, BN | 1 |
Lubberink, M | 1 |
Luurtsema, G | 1 |
Lammertsma, AA | 1 |
Sen, AP | 1 |
Boksa, P | 1 |
Quirion, R | 1 |
García-Albea, E | 1 |
Jiménez-Jiménez, FJ | 1 |
Ayuso-Peralta, L | 1 |
Cabrera-Valdivia, F | 1 |
Vaquero, A | 1 |
Tejeiro, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized, Double-blind, Placebo-controlled Trial of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells as a Disease-modifying Therapy for Idiopathic Parkinson's Disease[NCT04506073] | Phase 2 | 45 participants (Actual) | Interventional | 2020-11-09 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 other studies available for verapamil and Parkinson Disease
Article | Year |
---|---|
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Mice; Mice, Inbred S | 2016 |
Blood-brain barrier dysfunction in parkinsonian midbrain in vivo.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Female; Humans; | 2005 |
Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Mapping; C | 2008 |
Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease.
Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Calcium C | 2008 |
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases.
Topics: Aged; Alzheimer Disease; Autopsy; Binding Sites; Brain; Calcium; Calcium Channels; Dihydropyridines; | 1993 |
Parkinsonism unmasked by verapamil.
Topics: Antiparkinson Agents; Humans; Male; Middle Aged; Parkinson Disease; Verapamil | 1993 |