verapamil has been researched along with Osteogenic Sarcoma in 24 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A novel cancer stem-like cell line (3AB-OS), expressing a number of pluripotent stem cell markers, was irreversibly selected from human osteosarcoma MG-63 cells by long-term treatment (100 days) with 3-aminobenzamide (3AB)." | 7.75 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. ( De Blasio, A; Di Fiore, R; Ferrante, RD; Giuliano, M; Messina, C; Pirozzi, G; Santulli, A; Tesoriere, G; Tirino, V; Vento, R, 2009) |
| "The effect of fendiline, an anti-anginal drug, on cytosolic free Ca(2+) levels ([Ca(2+)](i)) in MG63 human osteosarcoma cells was explored by using fura-2 as a Ca(2+) indicator." | 7.71 | The anti-anginal drug fendiline increases intracellular Ca(2+) levels in MG63 human osteosarcoma cells. ( Chan, R; Cheng, J; Chou, K; Chung Lee, K; Jan, C; Lo, Y; Tang, K; Tseng, L; Wang, J, 2001) |
| "If verapamil was added after 4 days, the channel blocker did not diminish load-induced calcium incorporation." | 5.28 | Verapamil decreases cyclic load-induced calcium incorporation in ROS 17/2.8 osteosarcoma cell cultures. ( Banes, AJ; Vadiakas, GP, 1992) |
| "A novel cancer stem-like cell line (3AB-OS), expressing a number of pluripotent stem cell markers, was irreversibly selected from human osteosarcoma MG-63 cells by long-term treatment (100 days) with 3-aminobenzamide (3AB)." | 3.75 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. ( De Blasio, A; Di Fiore, R; Ferrante, RD; Giuliano, M; Messina, C; Pirozzi, G; Santulli, A; Tesoriere, G; Tirino, V; Vento, R, 2009) |
| "The effect of fendiline, an anti-anginal drug, on cytosolic free Ca(2+) levels ([Ca(2+)](i)) in MG63 human osteosarcoma cells was explored by using fura-2 as a Ca(2+) indicator." | 3.71 | The anti-anginal drug fendiline increases intracellular Ca(2+) levels in MG63 human osteosarcoma cells. ( Chan, R; Cheng, J; Chou, K; Chung Lee, K; Jan, C; Lo, Y; Tang, K; Tseng, L; Wang, J, 2001) |
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| "Current drug treatment for human osteosarcoma may include multiple chemotherapeutic agents, such as doxorubicin, cisplatin, and methotrexate." | 1.31 | Intrinsic resistance to chemotherapeutic agents in murine osteosarcoma cells. ( Ashihara, T; Gebhardt, MC; Hirasawa, Y; Kusuzaki, K; Mankin, HJ; Takeshita, H, 2000) |
| " As the phosphate concentration was increased, the biphasic fluoride dose-response curve was shifted to a lower range of fluoride concentrations." | 1.29 | Fluoride increases net 45Ca uptake by SaOS-2 cells: The effect is phosphate dependent. ( Farley, JR; Hall, SL; Herring, S; Tanner, MA, 1993) |
| "If verapamil was added after 4 days, the channel blocker did not diminish load-induced calcium incorporation." | 1.28 | Verapamil decreases cyclic load-induced calcium incorporation in ROS 17/2.8 osteosarcoma cell cultures. ( Banes, AJ; Vadiakas, GP, 1992) |
| "A subline of the Ridgway osteogenic sarcoma (ROS)--a murine subcutaneously-growing solid tumour--with moderate resistance (1." | 1.28 | Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine. ( Flanigan, P; Freshney, RI; Hamilton, TG; Kaye, SB; Merry, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 13 (54.17) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, Z | 1 |
| Wan, L | 1 |
| Han, Y | 1 |
| Meng, X | 1 |
| Yang, Q | 1 |
| Li, Y | 1 |
| Yu, Q | 1 |
| Shen, Z | 1 |
| Guo, C | 1 |
| Di Fiore, R | 1 |
| Santulli, A | 1 |
| Ferrante, RD | 1 |
| Giuliano, M | 1 |
| De Blasio, A | 1 |
| Messina, C | 1 |
| Pirozzi, G | 1 |
| Tirino, V | 1 |
| Tesoriere, G | 1 |
| Vento, R | 1 |
| Vazquez, G | 1 |
| Santillan, G | 1 |
| Boland, R | 1 |
| Roldán, E | 1 |
| Pérez-Lloret, A | 1 |
| Okada, T | 1 |
| Tanaka, K | 1 |
| Nakatani, F | 1 |
| Sakimura, R | 1 |
| Matsunobu, T | 1 |
| Li, X | 1 |
| Hanada, M | 1 |
| Nakamura, T | 1 |
| Oda, Y | 1 |
| Tsuneyoshi, M | 1 |
| Iwamoto, Y | 1 |
| Brach Del Prever, A | 2 |
| Massara, FM | 2 |
| Besenzon, L | 1 |
| Bianchi, M | 1 |
| Picci, P | 1 |
| Briccoli, A | 1 |
| Miniero, R | 2 |
| Cowie, FJ | 1 |
| Pinkerton, CR | 1 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Saroglia, EM | 1 |
| Soldano, S | 1 |
| Barisone, E | 1 |
| Leone, L | 1 |
| Arrighini, A | 1 |
| Andolina, M | 1 |
| Madon, E | 1 |
| Scotlandi, K | 2 |
| Serra, M | 2 |
| Manara, MC | 1 |
| Lollini, PL | 1 |
| Maurici, D | 1 |
| Del Bufalo, D | 1 |
| Baldini, N | 2 |
| Farley, JR | 1 |
| Hall, SL | 1 |
| Herring, S | 1 |
| Tanner, MA | 1 |
| Shikita, T | 1 |
| Zini, N | 1 |
| Ognibene, A | 1 |
| Santi, S | 1 |
| Ferracini, R | 1 |
| Maraldi, NM | 1 |
| Ramachandra, M | 1 |
| Ambudkar, SV | 2 |
| Gottesman, MM | 2 |
| Pastan, I | 2 |
| Hrycyna, CA | 2 |
| Airan, LE | 1 |
| Germann, UA | 1 |
| Takeshita, H | 1 |
| Kusuzaki, K | 1 |
| Ashihara, T | 1 |
| Gebhardt, MC | 1 |
| Mankin, HJ | 1 |
| Hirasawa, Y | 1 |
| Gomez, P | 1 |
| Vereecke, J | 1 |
| Himpens, B | 1 |
| Wang, J | 2 |
| Cheng, J | 1 |
| Chan, R | 1 |
| Tseng, L | 1 |
| Chou, K | 1 |
| Tang, K | 1 |
| Chung Lee, K | 1 |
| Lo, Y | 1 |
| Jan, C | 1 |
| Vadiakas, GP | 1 |
| Banes, AJ | 1 |
| Finkelman, RD | 1 |
| Mohan, S | 1 |
| Linkhart, TA | 1 |
| Abraham, SM | 1 |
| Boussy, JP | 1 |
| Baylink, DJ | 1 |
| Krieger, NS | 1 |
| Richter, C | 1 |
| Ferrier, J | 2 |
| Merry, S | 1 |
| Hamilton, TG | 1 |
| Flanigan, P | 1 |
| Freshney, RI | 1 |
| Kaye, SB | 1 |
| Guggino, SE | 1 |
| Wagner, JA | 1 |
| Snowman, AM | 1 |
| Hester, LD | 1 |
| Sacktor, B | 1 |
| Snyder, SH | 1 |
| Yamaguchi, DT | 1 |
| Green, J | 1 |
| Kleeman, CR | 1 |
| Muallem, S | 1 |
| Ward-Kesthely, A | 1 |
| Homble, F | 1 |
| Ross, S | 1 |
| Tsuchiya, H | 1 |
| Tomita, K | 1 |
1 trial available for verapamil and Osteogenic Sarcoma
| Article | Year |
|---|---|
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
23 other studies available for verapamil and Osteogenic Sarcoma
| Article | Year |
|---|---|
ABCB1-overexpressing MG63/DOX cell xenograft model: maintain the MDR phenotype in vivo.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette | 2013 |
Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment.
Topics: Adolescent; Adult; Apoptosis; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Biomark | 2009 |
Modulation of cytosolic calcium levels in osteoblast-like osteosarcoma cells by olpadronate and its amino-derivative IG-9402.
Topics: Animals; Calcitriol; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chick Embryo; Cy | 2003 |
Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms | 2006 |
[Treatment of metastatic osteosarcoma with verapamil, cyclosporine and chemotherapy. A case report].
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclosporine; Femur; Human | 1995 |
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Ch | 1994 |
Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transpor | 1994 |
Fluoride increases net 45Ca uptake by SaOS-2 cells: The effect is phosphate dependent.
Topics: Alkaline Phosphatase; Calcium; DNA; Dose-Response Relationship, Drug; Fluorides; Humans; Osteoblasts | 1993 |
Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cel | 1995 |
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transpor | 1996 |
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodi | 1998 |
Intrinsic resistance to chemotherapeutic agents in murine osteosarcoma cells.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Antibiotics, Antineoplastic; Antineoplastic A | 2000 |
Intra- and intercellular Ca(2+)-transient propagation in normal and high glucose solutions in ROS cells during mechanical stimulation.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcium; Calcium Channel Blockers; Calcium Signaling; C | 2001 |
The anti-anginal drug fendiline increases intracellular Ca(2+) levels in MG63 human osteosarcoma cells.
Topics: Calcium; Calcium Channel Blockers; Carcinogens; Chelating Agents; Fendiline; Fura-2; Humans; Osteosa | 2001 |
Verapamil decreases cyclic load-induced calcium incorporation in ROS 17/2.8 osteosarcoma cell cultures.
Topics: Animals; Bone Neoplasms; Calcium; Depression, Chemical; Osteoblasts; Osteosarcoma; Rats; Stress, Mec | 1992 |
PTH stimulates the proliferation of TE-85 human osteosarcoma cells by a mechanism not involving either increased cAMP or increased secretion of IGF-I, IGF-II or TGF beta.
Topics: Adenylyl Cyclases; Alkaline Phosphatase; Cell Division; Cyclic AMP; Humans; Insulin-Like Growth Fact | 1992 |
Demonstration of sodium/calcium exchange in rodent osteoblasts.
Topics: Animals; Biological Transport, Active; Bone Resorption; Calcium; Carrier Proteins; Cells, Cultured; | 1992 |
Continuously active sodium channels in osteoblastic ROS 17/2.8 cells.
Topics: Animals; Calcium; Conductometry; Membrane Potentials; Nifedipine; Osteoblasts; Osteosarcoma; Rats; S | 1991 |
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clomipramine; Dactinomycin; Doxorubicin; Dr | 1991 |
Phenylalkylamine-sensitive calcium channels in osteoblast-like osteosarcoma cells. Characterization by ligand binding and single channel recordings.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cations, Monovalent | 1988 |
Characterization of volume-sensitive, calcium-permeating pathways in the osteosarcoma cell line UMR-106-01.
Topics: Calcium; Cell Membrane Permeability; Cytosol; Diltiazem; Electric Conductivity; Kinetics; Lanthanum; | 1989 |
Further analysis of spontaneous membrane potential activity and the hyperpolarizing response to parathyroid hormone in osteoblastlike cells.
Topics: Animals; Bucladesine; Cell Line; Cell Membrane; Membrane Potentials; Microelectrodes; Osteoblasts; O | 1987 |
[The combined effect of anti-tumor agents with caffeine or calcium channel blockers on sarcoma cells by clonogenic assay].
Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Calcium Channel Blockers; Colony-Forming U | 1987 |