verapamil has been researched along with Neuroblastoma in 36 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Electrophysiological analysis of neuroblastoma X glioma hybrid (NG108-15) cells was used as an in vitro neuronal model system to evaluate antagonists of the K+-selective carboxylic ionophore, nigericin." | 7.70 | Studies on the prevention of nigericin action in neuroblastoma X glioma hybrid (NG108-15) cells. ( Doebler, JA, 2000) |
| " We investigated the effects of verapamil, a Ca2+ channel blocker, on human neuroblastoma cells as a representative tumor of childhood." | 7.67 | Importance of clinical exposure on verapamil enhancement of adriamycin-vincristine cytotoxicity in human neuroblastoma. ( Helson, C; Helson, L; Member, B, 1984) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 7.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| "The antitumor effect of combined use of cis-diamminedichloroplatinum(II) (CDDP) and verapamil, a calcium influx blocker, was examined in neuroblastoma transplanted to BALB/c athymic mice." | 7.67 | Verapamil enhancement of antitumor effect of cis-diamminedichloroplatinum(II) in nude mouse-grown human neuroblastoma. ( Harasawa, N; Ikeda, H; Kitamura, T; Nagamachi, Y; Nagashima, K; Nakamura, T; Nakano, G; Sakamoto, K, 1987) |
| "Maitotoxin (MTX) is a potent marine toxin isolated from the toxic dinoflagellate, Gambierdiscus toxicus." | 5.27 | Maitotoxin-induced membrane current in neuroblastoma cells. ( Kuroda, Y; Narahashi, T; Tsunoo, A; Wu, CH; Yoshii, M, 1987) |
| "Verapamil and the MDM2-p53 antagonists potentiated vincristine-mediated growth inhibition in a concentration-dependent manner when used in combination with high MDR-1-expressing p53 mutant neuroblastoma cell lines at concentrations that did not affect the viability of cells when given alone." | 3.80 | Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. ( Berry, P; Chen, L; Del Bello, F; Halliday, GC; Lunec, J; Middleton, SA; Newell, DR; Nichols, GL; Piergentili, A; Rousseau, RF; Tweddle, DA; Zhao, Y, 2014) |
| " Also inhibited peroxynitrite-mediated tyrosine nitration of alpha-synuclein in vitro and protected human neuroblastoma (SH-SY5Y) cells against SIN-1 and 6-OHDA toxicity when micromolar concentrations were used." | 3.78 | Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. ( Alonso-Gil, S; Chavarría, C; Gil, C; Morales Garcia, JA; Pérez, C; Perez, DI; Pérez-Castillo, A; Porcal, W; Souza, JM, 2012) |
| "Electrophysiological analysis of neuroblastoma X glioma hybrid (NG108-15) cells was used as an in vitro neuronal model system to evaluate antagonists of the K+-selective carboxylic ionophore, nigericin." | 3.70 | Studies on the prevention of nigericin action in neuroblastoma X glioma hybrid (NG108-15) cells. ( Doebler, JA, 2000) |
| " In both N1E-115 neuroblastoma cells and human embryonic kidney 293 cells stably expressing the 5-HT3 receptor As subunit, (+)-verapamil, (-)-verapamil, diltiazem, and nimodipine caused reversible and concentration-dependent (IC50 = 2." | 3.69 | Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels. ( Gunthorpe, MJ; Hargreaves, AC; Lummis, SC; Taylor, CW, 1996) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 3.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| "Intracellular calcium homeostasis and its modulation by different agents was studied in control and differentiated IMR32 human neuroblastoma cells by using the Ca2+-sensitive fluorescent dye quin2." | 3.67 | Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin. ( Clementi, F; Gotti, C; Madeddu, L; Pandiella, A; Sher, E, 1988) |
| "Several calcium antagonists were screened for their effect on muscarinic acetylcholine receptor-mediated cyclic GMP formation in murine neuroblastoma cells (clone N1E-115)." | 3.66 | Effect of some calcium antagonists on muscarinic receptor-mediated cyclic GMP formation. ( El-Fakahany, E; Richelson, E, 1983) |
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| "Recent evidence has supported the cancer stem cell theory that cancer contains a small number of cancer stem cells (CSC) as a reservoir of cancer cells." | 1.34 | Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. ( Hayashi, Y; Kaneko, M; Kaneko, S; Komuro, H; Saihara, R; Shinya, M; Takita, J, 2007) |
| "Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold." | 1.30 | Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997) |
| "Maitotoxin (MTX) is a potent marine toxin isolated from the toxic dinoflagellate, Gambierdiscus toxicus." | 1.27 | Maitotoxin-induced membrane current in neuroblastoma cells. ( Kuroda, Y; Narahashi, T; Tsunoo, A; Wu, CH; Yoshii, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (30.56) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 5 (13.89) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Chavarría, C | 1 |
| Perez, DI | 1 |
| Pérez, C | 1 |
| Morales Garcia, JA | 1 |
| Alonso-Gil, S | 1 |
| Pérez-Castillo, A | 1 |
| Gil, C | 1 |
| Souza, JM | 1 |
| Porcal, W | 1 |
| Xie, SS | 1 |
| Wang, X | 1 |
| Jiang, N | 1 |
| Yu, W | 1 |
| Wang, KD | 1 |
| Lan, JS | 1 |
| Li, ZR | 1 |
| Kong, LY | 1 |
| Szychowski, KA | 1 |
| Skóra, B | 1 |
| Tabęcka-Łonczyńska, A | 1 |
| Chen, L | 1 |
| Zhao, Y | 1 |
| Halliday, GC | 1 |
| Berry, P | 1 |
| Rousseau, RF | 1 |
| Middleton, SA | 1 |
| Nichols, GL | 1 |
| Del Bello, F | 1 |
| Piergentili, A | 1 |
| Newell, DR | 1 |
| Lunec, J | 1 |
| Tweddle, DA | 1 |
| Ohkubo, M | 1 |
| Miyamoto, A | 1 |
| Shiraishi, M | 1 |
| Sarang, SS | 1 |
| Yoshida, T | 1 |
| Cadet, R | 1 |
| Valeras, AS | 1 |
| Jensen, RV | 1 |
| Gullans, SR | 1 |
| Liu, PS | 1 |
| Chiung, YM | 1 |
| Kao, YY | 1 |
| Komuro, H | 1 |
| Saihara, R | 1 |
| Shinya, M | 1 |
| Takita, J | 1 |
| Kaneko, S | 1 |
| Kaneko, M | 1 |
| Hayashi, Y | 1 |
| Atlas, D | 1 |
| Adler, M | 1 |
| El-Fakahany, E | 1 |
| Richelson, E | 1 |
| Helson, L | 1 |
| Member, B | 1 |
| Helson, C | 1 |
| Donnelly-Roberts, DL | 1 |
| Arneric, SP | 1 |
| Sullivan, JP | 1 |
| Ichida, S | 1 |
| Wada, T | 1 |
| Nakazaki, S | 1 |
| Matsuda, N | 1 |
| Kishino, H | 1 |
| Akimoto, T | 1 |
| Cowie, FJ | 2 |
| Pinkerton, CR | 2 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Miniero, R | 1 |
| Massara, FM | 1 |
| Saroglia, EM | 1 |
| Soldano, S | 1 |
| Barisone, E | 1 |
| Leone, L | 1 |
| Arrighini, A | 1 |
| Andolina, M | 1 |
| Brach del Prever, A | 1 |
| Madon, E | 1 |
| Hayashi, T | 1 |
| Kagaya, A | 1 |
| Motohashi, N | 1 |
| Yamawaki, S | 1 |
| Chueh, SH | 1 |
| Kao, LS | 1 |
| Nostrandt, AC | 1 |
| Ehrich, M | 1 |
| Lo, TM | 1 |
| Thayer, SA | 1 |
| Kowtha, VC | 1 |
| Bryant, HJ | 1 |
| Krauthamer, V | 1 |
| Iwasa, KH | 1 |
| Stenger, DA | 1 |
| Hargreaves, AC | 1 |
| Gunthorpe, MJ | 1 |
| Taylor, CW | 1 |
| Lummis, SC | 1 |
| Hu, Q | 1 |
| Huang, F | 1 |
| Shi, Y | 1 |
| Gérard, V | 1 |
| Rouzaire-Dubois, B | 1 |
| Dilda, P | 1 |
| Dubois, JM | 1 |
| Pritchard-Jones, K | 1 |
| Renshaw, J | 1 |
| Ihnat, MA | 1 |
| Lariviere, JP | 1 |
| Warren, AJ | 1 |
| La Ronde, N | 1 |
| Blaxall, JR | 1 |
| Pierre, KM | 1 |
| Turpie, BW | 1 |
| Hamilton, JW | 1 |
| Doebler, JA | 1 |
| Ridley, DL | 1 |
| Rogers, A | 1 |
| Wonnacott, S | 1 |
| Galper, JB | 1 |
| Catterall, WA | 1 |
| Smets, LA | 1 |
| Janssen, M | 1 |
| Rutgers, M | 1 |
| Ritzen, K | 1 |
| Buttenhuis, C | 1 |
| Creba, JA | 1 |
| Karobath, M | 1 |
| Yoshii, M | 1 |
| Tsunoo, A | 1 |
| Kuroda, Y | 1 |
| Wu, CH | 1 |
| Narahashi, T | 1 |
| Bodewei, R | 1 |
| Hering, S | 1 |
| Schubert, B | 1 |
| Wollenberger, A | 1 |
| Sher, E | 1 |
| Gotti, C | 1 |
| Pandiella, A | 1 |
| Madeddu, L | 1 |
| Clementi, F | 1 |
| Cairo, MS | 1 |
| Siegel, S | 1 |
| Anas, N | 1 |
| Sender, L | 1 |
| Miwa, N | 1 |
| Sugino, H | 1 |
| Ueno, R | 1 |
| Hayaishi, O | 1 |
| Ikeda, H | 1 |
| Nakano, G | 1 |
| Nagashima, K | 1 |
| Sakamoto, K | 1 |
| Harasawa, N | 1 |
| Kitamura, T | 1 |
| Nakamura, T | 1 |
| Nagamachi, Y | 1 |
2 trials available for verapamil and Neuroblastoma
| Article | Year |
|---|---|
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Child; Child, | 1989 |
34 other studies available for verapamil and Neuroblastoma
| Article | Year |
|---|---|
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationsh | 2012 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cel | 2015 |
Calcium channel antagonists interfere with the mechanism of action of elastin-derived peptide VGVAPG in mouse cortical astrocytes in vitro.
Topics: Animals; Astrocytes; Calcium Channel Blockers; Dizocilpine Maleate; Elastin; Humans; Inflammation; M | 2022 |
Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2014 |
Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury.
Topics: Boron Compounds; Cadmium Poisoning; Calcium; Calcium Channel Blockers; Cell Line, Tumor; Chelating A | 2016 |
Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays.
Topics: Biological Assay; Drug Evaluation, Preclinical; Gene Expression Profiling; Gene Expression Regulatio | 2002 |
Effect of toluene diisocyanate on homeostasis of intracellular-free calcium in human neuroblastoma SH-SY5Y cells.
Topics: Atropine; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Line, Tumor; Cyt | 2006 |
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Topics: Cell Division; Cell Line, Tumor; Cell Separation; Child; Child, Preschool; Drug Resistance, Neoplasm | 2007 |
alpha-adrenergic antagonists as possible calcium channel inhibitors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Calcium; Cell Line; Cell Membran | 1981 |
Effect of some calcium antagonists on muscarinic receptor-mediated cyclic GMP formation.
Topics: Animals; Calcium; Carbachol; Cell Line; Cyclic GMP; Manganese; Mice; Neuroblastoma; Nickel; Quinucli | 1983 |
Importance of clinical exposure on verapamil enhancement of adriamycin-vincristine cytotoxicity in human neuroblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Child; Doxorubicin; Drug Resistance | 1984 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Ch | 1994 |
Possible mechanism of dantrolene stabilization of cultured neuroblastoma cell plasma membranes.
Topics: Animals; Calcium; Cell Membrane; Cell Membrane Permeability; Dantrolene; Dose-Response Relationship, | 1994 |
Extracellular ATP stimulates calcium influx in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Bradykinin; Calcium; Calcium Channel Blo | 1993 |
Modification of mipafox-induced inhibition of neuropathy target esterase in neuroblastoma cells of human origin.
Topics: Aldicarb; Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Humans; Isoflurophate; Nerve Growth | 1993 |
Refilling the inositol 1,4,5-trisphosphate-sensitive Ca2+ store in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Animals; Bradykinin; Calcium; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Flunar | 1993 |
Spontaneous firing of NG108-15 cells induced by transient exposure to ammonium chloride.
Topics: Amiloride; Ammonium Chloride; Animals; Cell Differentiation; Cell Membrane; Glioma; Hybrid Cells; Hy | 1996 |
Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.
Topics: Biguanides; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chann | 1996 |
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Alterations of ionic membrane permeabilities in multidrug-resistant neuroblastoma x glioma hybrid cells.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Membrane Permeability; Cell Size; Chlorid | 1998 |
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1998 |
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, | 1997 |
Studies on the prevention of nigericin action in neuroblastoma X glioma hybrid (NG108-15) cells.
Topics: Calcium Channel Blockers; Electrophysiology; Enzyme Inhibitors; Ionophores; Membrane Potentials; Neu | 2000 |
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sit | 2001 |
Inhibition of sodium channels by D600.
Topics: Binding, Competitive; Calcium; Cells, Cultured; Gallopamil; Ion Channels; Myocardium; Neoplasms, Exp | 1979 |
Pharmacokinetics and intracellular distribution of the tumor-targeted radiopharmaceutical m-iodo-benzylguanidine in SK-N-SH neuroblastoma and PC-12 pheochromocytoma cells.
Topics: 3-Iodobenzylguanidine; Acetylcholine; Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Autor | 1991 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Maitotoxin-induced membrane current in neuroblastoma cells.
Topics: Animals; Barium; Barium Compounds; Cell Line; Cell Membrane; Chlorides; Ion Channels; Marine Toxins; | 1987 |
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblasto | 1987 |
Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin.
Topics: Aminoquinolines; Arthropod Venoms; Atropine; Calcimycin; Calcium; Carbachol; Cytoplasm; Egtazic Acid | 1988 |
Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture.
Topics: Aminoquinolines; Animals; Calcium; Cyclic GMP; Diltiazem; Dinoprost; Dinoprostone; Fluorescent Dyes; | 1988 |
Verapamil enhancement of antitumor effect of cis-diamminedichloroplatinum(II) in nude mouse-grown human neuroblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Infant; Mice; Mi | 1987 |