verapamil has been researched along with Neoplasm Metastasis in 20 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses." | 9.08 | Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer. ( Dalton, WS; Dorr, RT; Mosley, K; Salmon, SE; Taylor, CW, 1997) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 9.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "In order to determine the clinical efficacy and adverse reactions of chemotherapy and verapamil infusion through a target artery to treat colorectal cancer patients with metastasis after failure with previous conventional treatments." | 5.15 | Clinical efficacy of chemotherapy combined with verapamil in metastatic colorectal patients. ( Duan, Q; Fan, P; Hu, B; Hu, L; Li, Y; Liu, Y; Lu, Z; Lv, R; Tong, S; Zhuang, J, 2011) |
| "We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses." | 5.08 | Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer. ( Dalton, WS; Dorr, RT; Mosley, K; Salmon, SE; Taylor, CW, 1997) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 5.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "Verapamil, a calcium channel antagonist, inhibits murine B16 melanoma and colon adenocarcinoma C26 tumor metastasis by altering platelet aggregation [Tsuruo, T." | 3.68 | Inhibition of tumor cell invasion by verapamil. ( Clothier, JL; Geary, RJ; Hendrix, MJ; Montague, SL; Welch, DR; Winters, AL; Yohem, KH, 1991) |
| "Verapamil, a calcium antagonist, inhibited both experimental (IV inoculation of tumor cells) and spontaneous metastasis (SC inoculation) of the highly metastatic B16 melanoma and colon adenocarcinoma 26 cell lines." | 3.67 | Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil. ( Iida, H; Kawabata, H; Makishima, F; Sakurai, Y; Tsukagoshi, S; Tsuruo, T; Yamori, T, 1985) |
| " Low-dose chemotherapy, which is the long-term administration of relatively low doses of chemotherapeutic agents, has been proposed for targeting tumor angiogenesis in various types of cancers." | 1.42 | Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel. ( Akiyama, K; Alam, MT; Hida, K; Hida, Y; Kawamoto, T; Maishi, N; Ohba, Y; Ohga, N; Ohmura, H; Shindoh, M; Torii, C; Yamada, K, 2015) |
| "Multiorgan metastasis of drug-resistant 4T1 breast tumors was totally resistant to doxorubicin treatment." | 1.37 | Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model. ( Bao, L; Dash, S; Haque, A; Hazari, S; Jackson, K; Jetly, R; Moroz, K, 2011) |
| "Highly metastatic B16 melanoma (B16M)-F10 cells, as compared with the low metastatic B16M-F1 line, have higher GSH content and preferentially overexpress BCL-2." | 1.33 | Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity. ( Asensi, M; Benlloch, M; Carretero, J; Estrela, JM; Ferrer, P; Obrador, E; Ortega, A; Segarra, R, 2005) |
| "The invasion and metastasis process involves degradation of the extracellular matrix mediated by tumor- and host-produced proteolytic enzymes." | 1.30 | Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells. ( Aguirre Ghiso, JA; Bal de Kier Joffé, E; Farías, EF; Ladeda, V, 1998) |
| "Murine CT-26 colon cancer cells growing in continuous culture (parental cells) were harvested and injected subcutaneously into the lateral flank (to produce subcutaneous tumors) or the lateral tail vein (to produce experimental lung metastases) of 10 8-week-old syngeneic male BALB/c mice." | 1.29 | Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. ( Bucana, CD; Dong, Z; Fan, D; Fidler, IJ; Radinsky, R; Tsan, R; Wilmanns, C, 1994) |
| "MTS1 is a metastasis-associated gene highly expressed in highly metastatic tumours." | 1.28 | Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma. ( Parker, C; Sherbet, GV, 1992) |
| "NL-44, however, did not form pulmonary metastasis even after the tumor cells had formed heterotypic aggregates with platelets, suggesting that tumor metastasis is dependent on the intrinsic nature of tumor cells." | 1.27 | [Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis]. ( Tsuruo, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 11 (55.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, DQ | 1 |
| Zhang, H | 1 |
| Tan, SJ | 1 |
| Gu, YC | 1 |
| Akiyama, K | 1 |
| Maishi, N | 1 |
| Ohga, N | 1 |
| Hida, Y | 1 |
| Ohba, Y | 1 |
| Alam, MT | 1 |
| Kawamoto, T | 1 |
| Ohmura, H | 1 |
| Yamada, K | 1 |
| Torii, C | 1 |
| Shindoh, M | 1 |
| Hida, K | 1 |
| Zhao, XY | 1 |
| Li, L | 1 |
| Wang, XB | 1 |
| Fu, RJ | 1 |
| Lv, YP | 1 |
| Jin, W | 1 |
| Meng, C | 1 |
| Chen, GQ | 1 |
| Huang, L | 1 |
| Zhao, KW | 1 |
| Bao, L | 1 |
| Haque, A | 1 |
| Jackson, K | 1 |
| Hazari, S | 1 |
| Moroz, K | 1 |
| Jetly, R | 1 |
| Dash, S | 1 |
| Liu, Y | 1 |
| Lu, Z | 1 |
| Fan, P | 1 |
| Duan, Q | 1 |
| Li, Y | 1 |
| Tong, S | 1 |
| Hu, B | 1 |
| Lv, R | 1 |
| Hu, L | 1 |
| Zhuang, J | 1 |
| Benlloch, M | 1 |
| Ortega, A | 1 |
| Ferrer, P | 1 |
| Segarra, R | 1 |
| Obrador, E | 1 |
| Asensi, M | 1 |
| Carretero, J | 1 |
| Estrela, JM | 1 |
| Brach Del Prever, A | 1 |
| Massara, FM | 1 |
| Besenzon, L | 1 |
| Bianchi, M | 1 |
| Picci, P | 1 |
| Briccoli, A | 1 |
| Miniero, R | 1 |
| Dong, Z | 1 |
| Radinsky, R | 1 |
| Fan, D | 1 |
| Tsan, R | 1 |
| Bucana, CD | 1 |
| Wilmanns, C | 1 |
| Fidler, IJ | 1 |
| Scheithauer, W | 1 |
| Kornek, G | 1 |
| Kastner, J | 1 |
| Raderer, M | 1 |
| Locker, G | 1 |
| Depisch, D | 1 |
| Pidlich, J | 1 |
| Tetzner, C | 1 |
| Mross, K | 1 |
| Bohn, C | 1 |
| Edler, L | 1 |
| Jonat, W | 1 |
| Queisser, W | 1 |
| Heidemann, E | 1 |
| Goebel, M | 1 |
| Hossfeld, DK | 1 |
| Mickisch, GH | 1 |
| Noordzij, MA | 1 |
| vd Gaast, A | 1 |
| Gebreamlack, P | 1 |
| Köhrmann, KU | 1 |
| Mogler-Drautz, E | 1 |
| Kupper, H | 1 |
| Schröder, FH | 1 |
| Taylor, CW | 1 |
| Dalton, WS | 1 |
| Mosley, K | 1 |
| Dorr, RT | 1 |
| Salmon, SE | 1 |
| Warner, E | 1 |
| Hedley, D | 1 |
| Andrulis, I | 1 |
| Myers, R | 1 |
| Trudeau, M | 1 |
| Warr, D | 1 |
| Pritchard, KI | 1 |
| Blackstein, M | 1 |
| Goss, PE | 1 |
| Franssen, E | 1 |
| Roche, K | 1 |
| Knight, S | 1 |
| Webster, S | 1 |
| Fraser, RA | 1 |
| Oldfield, S | 1 |
| Hill, W | 1 |
| Kates, R | 1 |
| Farías, EF | 1 |
| Aguirre Ghiso, JA | 1 |
| Ladeda, V | 1 |
| Bal de Kier Joffé, E | 1 |
| Parker, C | 1 |
| Sherbet, GV | 1 |
| Yohem, KH | 1 |
| Clothier, JL | 1 |
| Montague, SL | 1 |
| Geary, RJ | 1 |
| Winters, AL | 1 |
| Hendrix, MJ | 1 |
| Welch, DR | 1 |
| Ries, F | 1 |
| Dicato, M | 1 |
| Formelli, F | 1 |
| Cleris, L | 1 |
| Carsana, R | 1 |
| Tsuruo, T | 2 |
| Iida, H | 1 |
| Makishima, F | 1 |
| Yamori, T | 1 |
| Kawabata, H | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
7 trials available for verapamil and Neoplasm Metastasis
| Article | Year |
|---|---|
Clinical efficacy of chemotherapy combined with verapamil in metastatic colorectal patients.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopl | 2011 |
Phase II study of D-verapamil and doxorubicin in patients with metastatic colorectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Doxorubicin; Female; Hum | 1993 |
Randomized phase II study of single-agent epirubicin +/- verapamil in patients with advanced metastatic breast cancer. An AIO clinical trial. Arbeitsgemeinschaft Internistische Onkologie of the German Cancer Society.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Epirubicin; Female; H | 1993 |
Dexverapamil to modulate vinblastine resistance in metastatic renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1995 |
Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dex | 1997 |
Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen.
Topics: Adult; Aged; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; B | 1998 |
Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Eva | 1991 |
13 other studies available for verapamil and Neoplasm Metastasis
| Article | Year |
|---|---|
Nifedipine promotes the proliferation and migration of breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Express | 2014 |
Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel.
Topics: Administration, Metronomic; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; ATP | 2015 |
Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.
Topics: Animals; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2016 |
Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, T | 2011 |
Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity.
Topics: Animals; Apoptosis; Cell Adhesion; Cystic Fibrosis Transmembrane Conductance Regulator; Endothelium; | 2005 |
[Treatment of metastatic osteosarcoma with verapamil, cyclosporine and chemotherapy. A case report].
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclosporine; Femur; Human | 1995 |
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells.
Topics: Animals; Calcium Channel Blockers; Cell Division; Dose-Response Relationship, Drug; Endopeptidases; | 1998 |
Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma.
Topics: Animals; Blotting, Northern; Calcium; Calmodulin; Female; Gene Expression; Genetic Variation; Lung N | 1992 |
Inhibition of tumor cell invasion by verapamil.
Topics: Animals; Cytoskeletal Proteins; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma | 1991 |
Effect of verapamil on doxorubicin activity and pharmacokinetics in mice bearing resistant and sensitive solid tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Doxorubicin; Drug | 1988 |
[Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis].
Topics: Adenocarcinoma; Animals; Cell Line; Clone Cells; Colonic Neoplasms; Growth Substances; Lung Neoplasm | 1987 |
Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil.
Topics: Animals; Colonic Neoplasms; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metast | 1985 |